Vagus Nerve Stimulation

2018 ◽  
Vol 3 (2) ◽  
pp. 54-58
Author(s):  
Eric J. Yang ◽  
Sahil Sekhon ◽  
Kristen M. Beck ◽  
Isabelle M. Sanchez ◽  
Tina Bhutani ◽  
...  
Keyword(s):  
Psoriatic Arthritis ◽  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Animal Studies ◽  
Chronic Inflammatory Disease ◽  
Inflammatory Processes ◽  
Current Therapies ◽  
Inflammatory Bowel

Treatments for psoriasis and psoriatic arthritis have progressed at a rapid rate over the past 20 years, but treating patients with recalcitrant disease still remains a difficult task. Current therapies for these diseases involve topical agents, phototherapy, and systemic immunosuppression. However, the role of the nervous system in psoriasis and psoriatic arthritis remains largely unexplored. Recent animal studies and clinical trials have demonstrated that vagus nerve stimulation can decrease inflammatory processes in rheumatoid arthritis and inflammatory bowel disease. In this article, we outline the existing knowledge of the nervous system’s role in chronic inflammatory disease and discuss how these findings could be utilized in the future for treatment of psoriasis and psoriatic arthritis.

The Role of Vagus Nerve Stimulation in the Treatment of Epilepsy

2008 ◽  
Vol 3 (1) ◽  
pp. 91 ◽  
Author(s):  
Alexandra Montavont ◽  
Philippe Ryvlin ◽  
◽  
Keyword(s):  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Treatment Of Epilepsy

Transcutaneous Vagus Nerve Stimulation Enhances Post-error Slowing

2015 ◽  
Vol 27 (11) ◽  
pp. 2126-2132 ◽  
Author(s):  
Roberta Sellaro ◽  
Jelle W. R. van Leusden ◽  
Klodiana-Daphne Tona ◽  
Bart Verkuil ◽  
Sander Nieuwenhuis ◽  
...  
Keyword(s):  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Direct Evidence ◽  
Noradrenergic System ◽  
Group Design ◽  
Transcutaneous Vagus Nerve Stimulation ◽  
The Brain ◽  
Single Blind

People tend to slow down after they commit an error, a phenomenon known as post-error slowing (PES). It has been proposed that slowing after negative feedback or unforeseen errors is linked to the activity of the locus coeruleus–norepinephrine (LC–NE) system, but there is little direct evidence for this hypothesis. Here, we assessed the causal role of the noradrenergic system in modulating PES by applying transcutaneous vagus nerve stimulation (tVNS), a new noninvasive and safe method to stimulate the vagus nerve and to increase NE concentrations in the brain. A single-blind, sham-controlled, between-group design was used to assess the effect of tVNS in healthy young volunteers (n = 40) during two cognitive tasks designed to measure PES. Results showed increased PES during active tVNS, as compared with sham stimulation. This effect was of similar magnitude for the two tasks. These findings provide evidence for an important role of the noradrenergic system in PES.

Mo1787 Electrical Vagus Nerve Stimulation As an Innovative Treatment in Inflammatory Bowel Diseases

2016 ◽  
Vol 150 (4) ◽  
pp. S776 ◽  
Author(s):  
Valérie Sinniger ◽  
Sonia Pellissier ◽  
Dominique Hoffmann ◽  
Nicolas Mathieu ◽  
Candice Trocmé ◽  
...  
Keyword(s):  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Inflammatory Bowel Diseases ◽  
Vagus Nerve Stimulation ◽  
Innovative Treatment ◽  
Bowel Diseases ◽  
Inflammatory Bowel

The role of low-level vagus nerve stimulation in cardiac therapy

2019 ◽  
Vol 16 (8) ◽  
pp. 675-682 ◽  
Author(s):  
Yuhong Wang ◽  
Sunny S. Po ◽  
Benjamin J. Scherlag ◽  
Lilei Yu ◽  
Hong Jiang
Keyword(s):  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Low Level ◽  
Cardiac Therapy

scholarly journals The role of vagus nerve stimulation in refractory epilepsy

2017 ◽  
Vol 75 (9) ◽  
pp. 657-666 ◽  
Author(s):  
Tatiana Von Hertwig Fernandes de Oliveira ◽  
Alexandre Novicki Francisco ◽  
Zeferino Demartini Junior ◽  
Sergio Leandro Stebel
Keyword(s):  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Refractory Epilepsy ◽  
Focal Epilepsy ◽  
Sufficient Evidence ◽  
Battery Life ◽  
Future Perspectives ◽  
Transcutaneous Stimulation

ABSTRACT Vagus nerve stimulation is an adjunctive therapy used to treat patients with refractory epilepsy who are not candidates for resective surgery or had poor results after surgical procedures. Its mechanism of action is not yet fully comprehended but it possibly involves modulation of the locus coeruleus, thalamus and limbic circuit through noradrenergic and serotonergic projections. There is sufficient evidence to support its use in patients with focal epilepsy and other seizure types. However, it should be recognized that improvement is not immediate and increases over time. The majority of adverse events is stimulation-related, temporary and decreases after adjustment of settings. Future perspectives to improve efficacy and reduce side effects, such as different approaches to increase battery life, transcutaneous stimulation and identification of prognostic factors, should be further investigated.

scholarly journals Role of Cholinergic Receptors in Colorectal Cancer: Potential Therapeutic Implications of Vagus Nerve Stimulation?

2013 ◽  
Vol 04 (06) ◽  
pp. 1116-1131 ◽  
Author(s):  
Marjolaine Pelissier-Rota ◽  
Michèle Lainé ◽  
Benjamin Ducarouge ◽  
Bruno Bonaz ◽  
Muriel Jacquier-Sarlin
Keyword(s):  
Colorectal Cancer ◽  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Cholinergic Receptors ◽  
Therapeutic Implications

scholarly journals Therapeutic Potential of Vagus Nerve Stimulation for Inflammatory Bowel Diseases

2021 ◽  
Vol 15 ◽  
Author(s):  
Bruno Bonaz ◽  
Valérie Sinniger ◽  
Sonia Pellissier
Keyword(s):  
Nervous System ◽  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Inflammatory Bowel Diseases ◽  
Vagus Nerve Stimulation ◽  
Tnf Alpha ◽  
Bowel Diseases ◽  
Alpha Effect ◽  
Inflammatory Bowel ◽  
Anti Inflammatory

The vagus nerve is a mixed nerve, comprising 80% afferent fibers and 20% efferent fibers. It allows a bidirectional communication between the central nervous system and the digestive tract. It has a dual anti-inflammatory properties via activation of the hypothalamic pituitary adrenal axis, by its afferents, but also through a vago-vagal inflammatory reflex involving an afferent (vagal) and an efferent (vagal) arm, called the cholinergic anti-inflammatory pathway. Indeed, the release of acetylcholine at the end of its efferent fibers is able to inhibit the release of tumor necrosis factor (TNF) alpha by macrophages via an interneuron of the enteric nervous system synapsing between the efferent vagal endings and the macrophages and releasing acetylcholine. The vagus nerve also synapses with the splenic sympathetic nerve to inhibit the release of TNF-alpha by splenic macrophages. It can also activate the spinal sympathetic system after central integration of its afferents. This anti-TNF-alpha effect of the vagus nerve can be used in the treatment of chronic inflammatory bowel diseases, represented by Crohn’s disease and ulcerative colitis where this cytokine plays a key role. Bioelectronic medicine, via vagus nerve stimulation, may have an interest in this non-drug therapeutic approach as an alternative to conventional anti-TNF-alpha drugs, which are not devoid of side effects feared by patients.

Sign in / Sign up

Export Citation Format

Share Document