The anti-apoptotic effect of hydrogen sulfide attenuates injuries to the medullary respiratory centers of neonatal rats subjected to in utero cigarette smoke exposure

2013 ◽  
Vol 188 (1) ◽  
pp. 29-38 ◽  
Author(s):  
Lihong Nie ◽  
Yajie Hu ◽  
Xiang Yan ◽  
Mingqiang Li ◽  
Li Chen ◽  
...  
1997 ◽  
Vol 41 ◽  
pp. 91-91
Author(s):  
Kathleen M. Currey ◽  
Robert G. Meny ◽  
Kyle R. Cassell ◽  
Frank L. Vice ◽  
E. W. Holden

2019 ◽  
Vol 317 (2) ◽  
pp. L212-L221 ◽  
Author(s):  
Nagarjuna R. Cheemarla ◽  
Ifeanyi K. Uche ◽  
Kaitlin McBride ◽  
Shan Naidu ◽  
Antonieta Guerrero-Plata

Maternal smoking during pregnancy and exposure of infants to cigarette smoke are strongly associated with adverse health effects in childhood including higher susceptibility to respiratory viral infections. Human respiratory syncytial virus (HRSV) is the most important cause of lower respiratory tract infection among young infants. Exacerbation of respiratory disease, including HRSV bronchiolitis and higher susceptibility to HRSV infection, is well correlated with previous smoke exposure. The mechanisms of recurrence and susceptibility to viral pathogens after passive smoke exposure are multifactorial and include alteration of the structural and immunologic host defenses. In this work, we used a well-established mouse model of in utero smoke exposure to investigate the effect of in utero smoke exposure in HRSV-induced pathogenesis. Sample analysis indicated that in utero exposure led to increased lung inflammation characterized by an increased influx of neutrophils to the airways of the infected mice and a delayed viral clearance. On the other hand, decreased HRSV-specific CD8+T-cell response was observed. These findings indicate that cigarette smoke exposure during pregnancy alters HRSV-induced disease as well as several aspects of the neonatal immune responses.


2011 ◽  
Vol 38 (4) ◽  
pp. 932-938 ◽  
Author(s):  
A. N. Larcombe ◽  
R. E. Foong ◽  
L. J. Berry ◽  
G. R. Zosky ◽  
P. D. Sly

2007 ◽  
Vol 167 (6) ◽  
pp. 727-733 ◽  
Author(s):  
W. C. Strohsnitter ◽  
E. E. Hatch ◽  
M. Hyer ◽  
R. Troisi ◽  
R. H. Kaufman ◽  
...  

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