Central respiratory failure during acute organophosphate poisoning

2013 ◽  
Vol 189 (2) ◽  
pp. 403-410 ◽  
Author(s):  
Jennifer L. Carey ◽  
Courtney Dunn ◽  
Romolo J. Gaspari
Keyword(s):  
Respiratory Failure ◽  
Organophosphate Poisoning

scholarly journals Effect of organophosphorus compounds on the external respiratory function in rats during intratracheal and intraperitoneal administration

2021 ◽  
Author(s):  
Anastasiya A. Kryazhevskikh ◽  
Aleksey A. Kryazhevskikh ◽  
Svetlana N. Subbotina ◽  
Nataliia A. Sklyarova
Keyword(s):  
Respiratory Failure ◽  
Respiratory Function ◽  
Organophosphorus Compounds ◽  
Intraperitoneal Administration ◽  
Toxic Chemicals ◽  
Organophosphate Poisoning ◽  
Toxic Chemical ◽  
Intratracheal Administration ◽  
Chemical Factors ◽  
Lethal Doses

Due to the increasing influence of chemical factors on the human body, the experiment has been conducted using organophosphorus compounds (OPC) to stimulate poisoning cases in the production facilities. Given that the development of respiratory failure is a specific organophosphate poisoning symptom, a comparative analysis of external respiratory function (ERF) in rats with intratracheal and intraperitoneal administration of diisopropyl fluorophosphates (DFP) has been carried out. During the research, the average lethal doses of the toxic chemicals have been established, the conditions of DFP intoxication have been modeled. Thus, LD16 was 0.284 mg/kg by intratracheal administration, 1.6 mg/kg by intraperitoneal administration. Experimental data have shown that the intratracheal intake of OPC causes the development of respiratory failure in the first minutes after poisoning. The return of the ERF indicators to the background values was noted a day after poisoning. With the intraperitoneal administration of the toxic chemical, the rate of development of ERF disorders was lower, toxic effects persisted for two days. The data obtained can be used to make appropriate recommendations for the prevention of accidents and non-emergency cases in a production facility.

Q-T interval prolongation and pleomorphic ventricular tachyarrhythmia (`Torsade de pointes') in organophosphate poisoning: report of a case

1998 ◽  
Vol 17 (10) ◽  
pp. 587-590 ◽  
Author(s):  
Ming-Hsi Wang ◽  
Chuen-Den Tseng ◽  
Shyi-Yann Bair
Keyword(s):  
Respiratory Failure ◽  
Sinus Tachycardia ◽  
Cardiac Toxicity ◽  
Ventricular Tachyarrhythmia ◽  
Torsade De Pointes ◽  
Atropine Sulfate ◽  
Organophosphate Poisoning ◽  
Interval Prolongation ◽  
The Third ◽  
Practicing Physicians

1 A 63-year-old woman presented with drowsy consciousness and dyspnea, followed by respiratory failure, after taking a bottle of parathion for suicide. 2 Sinus tachycardia was noted initially by ECG and Q-T interval prolongation with pleomorphic ventricular tachyarrhythmia (`Torsade de pointes') occurred on the third day of admission. 3 Torsade de pointes was relieved by magnesium sulfate and atropine sulfate intravenously. Q-T interval returned to normal on the fifth day of admission. 4 Practicing physicians should be aware of this uncommon type of cardiac toxicity caused by organophosphate poisoning, Q-T interval prolongation and pleomorphic ventricular tachyarrhythmia.

Elevated amylase is related to the development of respiratory failure in organophosphate poisoning

1996 ◽  
Vol 15 (3) ◽  
pp. 250-253 ◽  
Author(s):  
N. Matsumiya ◽  
M. Tanaka ◽  
M. Iwai ◽  
T. Kondo ◽  
S. Takahashi ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Retrospective Study ◽  
Respiratory Failure ◽  
Activated Charcoal ◽  
Gastric Lavage ◽  
Ventilatory Support ◽  
Organophosphate Poisoning ◽  
Amylase Level ◽  
Normal Range

1 A retrospective study of organophosphate(OP) poison ing in the intensive care unit was performed to analyze the incidence of respiratory failure. 2 The patients were treated initially with gastrointest inal decontamination including gastric lavage and the administration of activated charcoal with cathartic. Further management included intravenous pralidoxim and atropine and ventilatory support. 3 Of the 32 OP poisoning patients, 16 patients developed respiratory failure and received ventilatory support. 4 An increase in plasma amylase above the normal range on the day of admission was related to the development of respiratory failure. 5 In OP poisoning, the elevation of amylase level was predictive of the subsequent respiratory failure.

scholarly journals Respiratory Failure Following Organophosphate Poisoning: A Literature Review

Cureus ◽  
2017 ◽  
Author(s):  
Pirthvi Raj Giyanwani ◽  
Ujala Zubair ◽  
Osama Salam ◽  
Zarafshan Zubair
Keyword(s):  
Respiratory Failure ◽  
Literature Review ◽  
Organophosphate Poisoning

scholarly journals Two Cases of Respiratory Failure After Recovery of Cholinergic Crisis in Organophosphate Poisoning: The Intermediate Syndrome

1999 ◽  
Vol 47 (2) ◽  
pp. 247
Author(s):  
Dae Kyoung Cho ◽  
Seung Eun Lee ◽  
Jae Joong Baik ◽  
Yeontae Chung ◽  
Keun Ho Chung
Keyword(s):  
Respiratory Failure ◽  
Organophosphate Poisoning

scholarly journals Clinical profile and outcome of intermediate syndrome in acute organophosphate poisoning

2018 ◽  
Vol 5 (1) ◽  
pp. 62
Author(s):  
Rajendran Velayudham ◽  
Senthilkumar S. ◽  
Viswanathan Pandurangan
Keyword(s):  
Respiratory Failure ◽  
Early Recognition ◽  
Ventilatory Support ◽  
Serum Cholinesterase ◽  
Organophosphate Poisoning ◽  
Poison Center ◽  
Close Monitoring ◽  
Duration Of Symptoms ◽  
Ventilator Support ◽  
Agriculture Sector

Background: Deaths by acute organ phosphorus poisoning is very common in rural India especially in people associated with agriculture sector. The present study was aimed to study the clinical characteristics of organ phosphorus compound (OPC) poisoning and to assess the associated factors related to the outcome (recovery/death) of intermediate syndrome (IMS).Methods: This is an observational study conducted on 40 patients showing features of intermediate syndrome at Poison center, Institute of internal medicine, Rajiv Gandhi Government General Hospital, Chennai. Detailed clinical examination was done on the day of admission and daily with close monitoring. All patients included under study will be treated with pralidoxime as per protocol, atropine as required and other supportive measures was provided. Mechanical ventilatory support was provided for patients in respiratory failure. Patients are followed up till the end point of outcome (recovered and discharged/death) that was correlated with type of compound, quantum of exposure, duration of IMS, serum cholinesterase and creatinine kinase levels and respiratory failure.Result: Patients of age group between 30-40 years are more affected. Males outnumbered the females and most of them are from agriculture sector (65%). Out of 40, on treatment and follow up 34 patients were recovered and 6 were died. Onset of intermediate syndrome ranges between days 2-4 following exposure and duration of symptoms was observed for 5–16 days. Methylparathion was the frequent compound associated with IMS in about 9 cases. Out of 40, 16 had respiratory failure and given ventilator support. Proximal muscle weakness was seen in about 38 patients as common symptom.Conclusion: The results of the present study concludes that factors such as mode of poisoning, onset of IMS, type of compound, PChE level are not correlated with the outcome of study. Duration of IMS, respiratory failure, ventilator associated pneumonia (VAP), ventilator support duration were associated with outcome of the study. Hence, early recognition of IMS and its associated respiratory paralysis is very important in patients affected with OPC toxicity to prevent morbidity and mortality rate. 

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