scholarly journals Clinical results following intra-articular injection of adipose-derived stromal vascular fraction cells in patients with osteoarthritis of the knee

2017 ◽  
Vol 6 ◽  
pp. 108-112 ◽  
Author(s):  
Naomasa Yokota ◽  
Masayuki Yamakawa ◽  
Tomohiko Shirata ◽  
Tetsuya Kimura ◽  
Hideto Kaneshima
Keyword(s):  
Stromal Vascular Fraction ◽  
Clinical Results ◽  
Osteoarthritis Of The Knee

scholarly journals Stromal Vascular Fraction for Osteoarthritis of the Knee Regenerative Engineering

2021 ◽  
Author(s):  
Chinedu C. Ude ◽  
Shiv Shah ◽  
Kenneth S. Ogueri ◽  
Lakshmi S. Nair ◽  
Cato T. Laurencin
Keyword(s):  
Quality Of Life ◽  
Clinical Evidence ◽  
Point Of Care ◽  
Stromal Vascular Fraction ◽  
Clinic Visit ◽  
Osteoarthritis Of The Knee ◽  
Clinical Patient ◽  
Inflammatory Proteins ◽  
Anti Inflammatory

Abstract Purpose The knee joint is prone to osteoarthritis (OA) due to its anatomical position, and several reports have implicated the imbalance between catabolic and anabolic processes within the joint as the main culprit, thus leading to investigations towards attenuation of these inflammatory signals for OA treatment. In this review, we have explored clinical evidence supporting the use of stromal vascular fraction (SVF), known for its anti-inflammatory characteristics for the treatment of OA. Methods Searches were made on PubMed, PMC, and Google Scholar with the keywords “adipose fraction knee regeneration, and stromal vascular fraction knee regeneration, and limiting searches within 2017–2020. Results Frequently found interventions include cultured adipose-derived stem cells (ADSCs), SVF, and the micronized/microfragmented adipose tissue-stromal vascular fraction (MAT-SVF). Clinical data reported that joints treated with SVF provided a better quality of life to patients. Currently, MAT-SVF obtained and administered at the point of care is approved by the Food and Drug Administration (FDA), but more studies including manufacturing validation, safety, and proof of pharmacological activity are needed for SVF. The mechanism of action of MAT-SVF is also not fully understood. However, the current hypothesis indicates a direct adherence and integration with the degenerative host tissue, and/or trophic effects resulting from the secretome of constituent cells. Conclusion Our review of the literature on stromal vascular fraction and related therapy use has found evidence of efficacy in results. More research and clinical patient follow-up are needed to determine the proper place of these therapies in the treatment of osteoarthritis of the knee. Lay Summary Reports have implicated the increased inflammatory proteins within the joints as the main cause of osteoarthritis (OA). This has attracted interest towards addressing these inflammatory proteins as a way of treatment for OA. The concentrated cell-packed portion of the adipose product stromal vascular fraction (SVF) from liposuction or other methods possesses anti-inflammatory effects and has been acclaimed to heal OA. Thus, we searched for clinical evidence supporting their use, for OA treatment through examining the literature. Data from various hospitals support that joints treated with SVF provided a better quality of life to patients. Currently, there is at least one version of these products that are obtained and given back to patients during a single clinic visit, approved by the FDA.

scholarly journals Clinical Results of Tibial Condyle Valgus Osteotomy for Severe Osteoarthritis of the Knee

2004 ◽  
Vol 53 (1) ◽  
pp. 35-39
Author(s):  
Takashi Miyamoto ◽  
Kenji Miyahara ◽  
Yoshiaki Makino ◽  
Yuji Sugitani
Keyword(s):  
Clinical Results ◽  
Osteoarthritis Of The Knee ◽  
Valgus Osteotomy ◽  
Tibial Condyle

scholarly journals Development of Autologous Platelet-Rich Plasma Mixed-Microfat as an Advanced Therapy Medicinal Product for Intra-Articular Injection of Radio-Carpal Osteoarthritis: From Validation Data to Preliminary Clinical Results

2019 ◽  
Vol 20 (5) ◽  
pp. 1111 ◽  
Author(s):  
Alice Mayoly ◽  
Aurélie Iniesta ◽  
Caroline Curvale ◽  
Najib Kachouh ◽  
Charlotte Jaloux ◽  
...  
Keyword(s):  
Medicinal Product ◽  
Platelet Rich Plasma ◽  
Stromal Vascular Fraction ◽  
Clinical Results ◽  
Advanced Therapy Medicinal Product ◽  
Validation Data ◽  
Painful Condition ◽  
Advanced Therapy ◽  
Functional Scores

Wrist osteoarthritis (OA) is one of the most common conditions encountered by hand surgeons with limited efficacy of non-surgical treatments. The purpose of this study is to describe the Platelet-Rich Plasma (PRP) mixed-microfat biological characteristics of an experimental Advanced Therapy Medicinal Product (ATMP) needed for clinical trial authorization and describe the clinical results obtained from our first three patients 12 months after treatment (NCT03164122). Biological characterization of microfat, PRP and mixture were analysed in vitro according to validated methods. Patients with stage four OA according to the Kellgren Lawrence classification, with failure to conservative treatment and a persistent daily painful condition >40 mm according to the visual analog scale (VAS) were treated. Microfat-PRP ATMP is a product with high platelet purity, conserved viability of stromal vascular fraction cells, chondrogenic differentiation capacity in vitro and high secretion of IL-1Ra anti-inflammatory cytokine. For patients, the only side effect was pain at the adipose tissue harvesting sites. Potential efficacy was observed with a pain decrease of over 50% (per VAS score) and the achievement of minimal clinically important differences for DASH and PRWE functional scores at one year in all three patients. Microfat-PRP ATMP presented a good safety profile after an injection in wrist OA. Efficacy trials are necessary to assess whether this innovative strategy could delay the necessity to perform non-conservative surgery.

Expanding Clinical Indications of Mechanically Isolated Stromal Vascular Fraction: A Systematic Review

2020 ◽  
Vol 40 (9) ◽  
pp. NP546-NP560 ◽  
Author(s):  
Mohammad Ghiasloo ◽  
Rodolfo C Lobato ◽  
Juan M Díaz ◽  
Kashika Singh ◽  
Alexis Verpaele ◽  
...  
Keyword(s):  
Systematic Review ◽  
Adverse Events ◽  
Stromal Vascular Fraction ◽  
Perianal Fistula ◽  
Clinical Results ◽  
Temporomandibular Joint Disorders ◽  
Therapeutic Modality ◽  
Future Research ◽  
Cochrane Central Register ◽  
Clinical Indications

Abstract Background Mechanically isolated stromal vascular fraction (tSVF, tissue SVF) is a potent regenerative solution, increasingly used as a therapeutic modality for a variety of pathologies. With recent evidence conclusively favoring mechanical isolation over enzymatic alternatives, the therapeutic share and indications of tSVF are expected to grow even further. Objectives The aim of this study was to provide a systematic review of all studies reporting on the use of tSVF. Methods A systematic search was undertaken of the Embase, PubMed, Web of Science, and Cochrane Central Register of Controlled Trials databases. Outcome measures included clinical indications, such as recipient area, adverse events, clinical results recipient area, method of application, follow-up duration and evaluation methods. Results Of the total of 4505 articles identified, 186 full-texts were screened. Thirty-four studies, reporting on 1443 patients were included. tSVF-based therapy was observed for 10 different pathologies, including aged skin (8 studies), scars (5), wounds (6), osteoarthritis (6), tendinopathy (2), temporomandibular joint disorders (1), androgenic alopecia (1), perianal fistula (3), migraine (1), and vocal fold scarring (1). Across all studies, tSVF-based therapy resulted in favorable clinical results. Overall, 50 (3.43%) minor and one (0.07%) major adverse events were observed, mainly related to the liposuction procedure. Conclusions tSVF offers a safe, easy and legal treatment modality for a range of indications. Future research is indicated to identify the optimal isolation protocol, dose and timing. In addition, basic research remains crucial to identify the mechanism of action of SVF within different pathologies. Level of Evidence: 4

scholarly journals Short-term clinical results of intra-articular PRP injections for early osteoarthritis of the knee

2017 ◽  
Vol 42 ◽  
pp. 117-122 ◽  
Author(s):  
Po-Hua Huang ◽  
Ching-Jen Wang ◽  
Wen-Yi Chou ◽  
Jun-Wen Wang ◽  
Jih-Yang Ko
Keyword(s):  
Clinical Results ◽  
Osteoarthritis Of The Knee ◽  
Early Osteoarthritis ◽  
Short Term
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