Neuropsychological profile of adults with Down syndrome and moderate intellectual disability

2020 ◽  
Vol 107 ◽  
pp. 103781
Author(s):  
Camino Fernández-Alcaraz ◽  
Fernando Carvajal
Keyword(s):  
Down Syndrome ◽  
Intellectual Disability ◽  
Moderate Intellectual Disability ◽  
Neuropsychological Profile

Physical Performance of Individuals with Intellectual Disability: A 30-Year Follow-Up

2007 ◽  
Vol 24 (2) ◽  
pp. 125-143 ◽  
Author(s):  
Ulla Lahtinen ◽  
Pauli Rintala ◽  
Antero Malin
Keyword(s):  
Gender Differences ◽  
Down Syndrome ◽  
Intellectual Disability ◽  
Physical Performance ◽  
Manual Dexterity ◽  
Static Balance ◽  
Moderate Intellectual Disability ◽  
Over Time ◽  
Individuals With Intellectual Disabilities

Physical performance of Finnish adolescents (33 females, 44 males) with moderate intellectual disability (ID) was studied over a 30-year period. This study is an extension of Lahtinen’s previous work on documenting the performance of individuals with intellectual disabilities over time. This study consisted of analyzing data from a total of four data collection periods (1973, 1979, 1996, and 2003 in which participants ranged in age from 11-16, 17-22, 34-39 and 41-46 years old, respectively). Improvement from early to late adolescence, and decline during adulthood in abdominal strength/endurance, static balance, and manual dexterity were identified. The male adults with ID were moderately overweight (BMI), but the females with ID were obese. The IQ effect was significant on balance and manual dexterity. The gender differences in adulthood were significant, but differences were not noted for Down syndrome when controlling for IQ.

The Use of Response Prompting and Frames for Teaching Sentence Writing to Students With Moderate Intellectual Disability

2016 ◽  
Vol 33 (3) ◽  
pp. 142-149 ◽  
Author(s):  
Robert Pennington ◽  
Allison Flick ◽  
Kendra Smith-Wehr
Keyword(s):  
Intellectual Disability ◽  
Time Delay ◽  
Delay System ◽  
Constant Time Delay ◽  
Intervention Package ◽  
Time Delay System ◽  
Moderate Intellectual Disability ◽  
System Of Least Prompts ◽  
Response Prompting ◽  
Multiple Probe

In the current study, we examined the effects of response prompting strategies (i.e., constant time delay, system of least prompts) and frames on sentence writing for three participants, ages 7 to 12, with moderate intellectual disability. We used a concurrent multiple probe across behaviors design to evaluate the efficacy of the intervention package and posttest probes to assess generalized responding to untrained stimulation. During intervention, the teacher taught two students to construct sentences using selection-based software and another to generate handwritten responses across three different writing frames (i.e., I want _________, I see _____, The _____ is ______). Our findings suggest that the package was effective and produced variable levels of maintenance and generalized responding for all three participants.

scholarly journals Mutations Impairing GSK3-Mediated MAF Phosphorylation Cause Cataract, Deafness, Intellectual Disability, Seizures, and a Down Syndrome-like Facies

2015 ◽  
Vol 96 (5) ◽  
pp. 816-825 ◽  
Author(s):  
Marcello Niceta ◽  
Emilia Stellacci ◽  
Karen W. Gripp ◽  
Giuseppe Zampino ◽  
Maria Kousi ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Intellectual Disability

Animal Models of Down Syndrome

2021 ◽  
Author(s):  
Anna J. Moyer ◽  
Roger H. Reeves
Keyword(s):  
Down Syndrome ◽  
Cognitive Impairment ◽  
Intellectual Disability ◽  
Animal Models ◽  
Brain Regions ◽  
Laboratory Mice ◽  
Tremendous Progress ◽  
New Treatments ◽  
And Function ◽  
Early Developmental

Is intellectual disability a treatable feature of persons with Down syndrome? Researchers have made tremendous progress in the last 30 years, from creating the first mouse model of Down syndrome to completing the first major clinical trial for cognitive impairment in people with Down syndrome. Until recently, normalizing brain development and function seemed too lofty a goal, and indeed, even proposing a candidate therapy requires answering a number of difficult questions. How does trisomy 21, a molecular diagnosis, cause the clinical phenotypes of Down syndrome? When, where, and how do trisomic genes act to disrupt normal development and which genes are involved with which outcomes? Which brain regions and behaviors are most impaired? Is there an early developmental window of time during which treatments are most effective? This article discusses how animal models such as laboratory mice can be used to understand intellectual disability and to develop new treatments for cognitive impairment.

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