Combined lung-kidney transplantation: first case in Portugal

Despite significant advances in transplantation of HIV-infected individuals, little is known about HIV coinfected patients with hepatitis C virus (HCV) genotypes other than genotype 1, especially when receiving HCV-infected organs with a different genotype. We describe the first case of kidney transplantation in a man coinfected with hepatitis C and HIV in our state. To our knowledge, this is also the first report of an HIV/HCV/HBV tri-infected patient with non-1 (2a) HCV genotype who received an HCV-infected kidney graft with the discordant genotype (1a), to which he converted after transplant. Our case study highlights the following: (1) transplant centers need to monitor wait times for an HCV-infected organ and regularly assess the risk of delaying HCV antiviral treatment for HCV-infected transplant candidates in anticipation of the transplant from an HCV-infected donor; (2) closer monitoring of tacrolimus levels during the early phases of anti-HCV protease inhibitor introduction and discontinuation may be indicated; (3) donor genotype transmission can occur; (4) HIV/HCV coinfected transplant candidates require a holistic approach with emphasis on the cardiovascular risk profile and low threshold for cardiac catheterization as part of their pretransplant evaluation.

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Nephrogenic Adenoma of the Urinary Bladder after Kidney Transplantation: Long-Term Follow-Up

Case Reports in Transplantation ◽

10.1155/2020/8831966 ◽

2020 ◽

Vol 2020 ◽

pp. 1-3

Author(s):

Iftikhar Khan ◽

Mahmoud Obeid ◽

Nasreen Hasan ◽

Fayyad Jaradat ◽

Bodhisatwa Sengupta ◽

...

Keyword(s):

Kidney Transplantation ◽

Urinary Bladder ◽

Histopathological Examination ◽

Transitional Epithelium ◽

Nephrogenic Adenoma ◽

Term Outcome ◽

Long Term Outcome ◽

First Case

Nephrogenic adenoma is a rare lesion that consists of epithelial cells arranged in tubular form, resembling tubules in the renal medulla, and is found usually in the urinary bladder although it can occur anywhere in the transitional epithelium of the lower urinary tract. The first case of nephrogenic adenoma of the urinary bladder was reported before the first kidney transplantation, and the lesion has been reported in patients with and without renal transplantation. The origin of cells in nephrogenic adenoma is debated and has been postulated to arise from cells of embryonic origin or from metaplasia secondary to chronic irritation or from implantation of allograft cells in patients with kidney transplantation. The long-term outcome and potential to convert into malignancy are not established, and therefore, there are no recommendations on how to follow up these patients. We present a case of a patient who was found to have nephrogenic adenoma of the urinary bladder during his second kidney transplantation from a cadaveric donor. He had undergone living donor kidney transplantation previously which subsequently failed. The patient did not manifest any symptoms of nephrogenic adenoma. During a follow-up period of 5 years, he has not manifested any symptoms related to nephrogenic metaplasia. Histopathological examination 5 years after the second transplantation did not show any malignant change. It can be concluded that nephrogenic adenoma is likely to behave in benign fashion post kidney transplantation.

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P1693LONG-TERM OUTCOME OF KIDNEY TRANSPLANTATION IN PLASMA CELLS DYSCRASIAS

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfaa142.p1693 ◽

2020 ◽

Vol 35 (Supplement_3) ◽

Author(s):

Fulvia Zappulo ◽

Gabriele Donati ◽

Giorgia Comai ◽

Claudia Bini ◽

Andrea Angeletti ◽

...

Keyword(s):

Kidney Transplantation ◽

Light Chain ◽

Graft Failure ◽

Case Series ◽

University Hospital ◽

High Dose ◽

Light Chain Deposition Disease ◽

Light Chain Amyloidosis ◽

First Case

Abstract Background and Aims Survival of patients with Multiple Myeloma (MM), Light Chain Amyloidosis (LCA) and Monoclonal Gammopathies of renal significance (MGRS) on chronic renal replacement therapy (RRT) is poor. The gold standand treatment of plasma cell dyscrasias (PCD) is high-dose chemotherapy followed by Autologous Stem Cell Transplantation (ASCT) which can induce complete remission and longer survival than chemotherapy alone. Kidney transplantation (KT) after ASCT could represent an option for patients with PCD and End Stage Renal Disease (ESRD). There is no evidence about the time of follow up required from MM remission and KT. Method We present a case series of 5 patients who underwent KT after ASCT and remission of MM among 2,500 transplant recipients followed at the Nephrology Dialysis and Renal Transplantation Unit of S.Orsola University Hospital from 1967 untill now. As in case of recovery from solid cancers, the feasibility of KT after MM was considered when no signs of relapse were assessed. In our cohort 3 patients were affected by Light Chain Deposition Disease (LCDD), 1 patient presented Myeloma Cast Nephropathy (MCN) and one patient Light Chain Amyloidosis (LCA). They all required RRT and underwent KT after ASCT. Results Time between ASCT and KT ranged from 3 and 11 years and clinical outcome was very different. The mean follow up period ranged from 2 to 4 years. In the first case (LCDD) KT was performed 11 years after ASCT, the graft failure occurred 6 years later because of chronic allograft nephropathy requiring RRT. In the second case (LCDD) patient received KT 3 years after ASCT. He developed Bence-Jones proteinuria requiring specific therapy with Dexametasone and Bortezomib determining progressive graft failure. In the third case (LCDD) KT was performed 4 years after ASCT and the 4 year follow up is negative for relapse of MM or ESRD. The fourth patient presented MCN and received KT 8 years after ASCT. MCN relapsed 6 years later; it caused ESRD requiring RRT. In the last patient (LCA) KT was performed 4 years after ASCT. No recurrence occurred in a 2-year follow up. Conclusion MM is the most frequent malignancy in dialytic population; the need for KT in MM remains high. ASCT improves the quality of life and offers higher survival in patients with myeloma/MGRS/amyloidosis-related ESRD. Therefore the combination of chemotherapy/ASCT and KT is pivotal to pursue renal restoring. Since high risk of recurrence larger study are required to clarify the better follow up period after MM remission and KT.

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First Case of Toxocara Eosinophilic Ascites After Combined Pancreas and Kidney Transplantation

American Journal of Transplantation ◽

10.1111/j.1600-6143.2010.03325.x ◽

2010 ◽

Vol 10 (12) ◽

pp. 2727-2727 ◽

Cited By ~ 5

Author(s):

S. Schaffellner ◽

D. Wagner ◽

M. Sereinigg ◽

E. Jakoby ◽

D. Kniepeiss ◽

...

Keyword(s):

Kidney Transplantation ◽

First Case ◽

Eosinophilic Ascites

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Robotic-assisted kidney transplantation: our first case

World Journal of Urology ◽

10.1007/s00345-015-1673-6 ◽

2015 ◽

Vol 34 (3) ◽

pp. 443-447 ◽

Cited By ~ 16

Author(s):

A. Breda ◽

L. Gausa ◽

A. Territo ◽

J. M. López-Martínez ◽

O. Rodríguez-Faba ◽

...

Keyword(s):

Kidney Transplantation ◽

Robotic Assisted ◽

First Case

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Renal Mucormycosis: A Rare and Potentially Lethal Complication of Kidney Transplantation

Case Reports in Transplantation ◽

10.1155/2013/915423 ◽

2013 ◽

Vol 2013 ◽

pp. 1-6

Author(s):

SreyRam Kuy ◽

Chun He ◽

David C. Cronin

Keyword(s):

Kidney Transplantation ◽

Amphotericin B ◽

Early Recognition ◽

Deceased Donor ◽

The United States ◽

Successful Outcome ◽

Early Presentation ◽

First Case ◽

Allograft Biopsy ◽

Transplant Nephrectomy

Renal mucormycosis is a rare and potentially lethal complication of kidney transplantation. We describe two cases of renal mucormycosis following deceased donor kidney transplantation. This is the second report of renal mucormycosis following kidney transplantation in the United States, and the first case of renal mucormycosis infection presumed to be of recipient origin. Case A had an early presentation of mucormycosis isolated to the kidney allograft. He had an unexpected rise in serum creatinine and leukocytosis necessitating allograft biopsy which showed mucormycosis. He underwent transplant nephrectomy on posttransplant day 11, was treated with amphotericin B, and discharged home on posttransplant day 22. Case B had a late presentation of renal mucormycosis, preceded by a cutaneous manifestation. One year after kidney transplantation he had a nonhealing knee ulcer which on biopsy showed cutaneous mucormycosis. Treatment included aggressive debridement and amphotericin B. Allograft biopsy showed mucormycosis, necessitating transplant nephrectomy. He was discharged to a rehabilitation facility and died from noninfectious causes. Review of the published literature of renal mucormycosis cases following kidney transplantation reveals a mortality rate of more than 50%. The key to successful outcome is early recognition, prompt institution of surgical debridement of all infected tissue, and appropriate antifungal therapy.

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First Case of Simultaneous Heart Plus Kidney Transplantation in Chile: Case Report

Transplantation Proceedings ◽

10.1016/j.transproceed.2007.02.044 ◽

2007 ◽

Vol 39 (3) ◽

pp. 625-626 ◽

Cited By ~ 1

Author(s):

L. Sepúlveda ◽

J. Zamorano ◽

A. Cotera ◽

N. Núñez ◽

M. Llancaqueo ◽

...

Keyword(s):

Kidney Transplantation ◽

Case Report ◽

First Case

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Intraperitoneal laparoscopic Mitrofanoff procedure: Ureterocutaneostomy concomitant nephrectomy in a child with kidney transplantation: First case report

Trends in Transplantation ◽

10.15761/tit.1000223 ◽

2017 ◽

Vol 10 (2) ◽

Author(s):

Pierre Jean Aurelus ◽

Hermilo De La Cruz Yáñez ◽

Alfonso Yamamoto Nagano ◽

Amílcar Almonte Pineda ◽

Guillermo Godoy Rabago ◽

...

Keyword(s):

Kidney Transplantation ◽

Case Report ◽

First Case

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Kidney Transplantation after Extended Multivisceral Resection for Pancreatic Ductal Adenocarcinoma

Case Reports in Transplantation ◽

10.1155/2018/3757382 ◽

2018 ◽

Vol 2018 ◽

pp. 1-3

Author(s):

Hryhoriy Lapshyn ◽

Louisa Bolm ◽

Martin Nitschke ◽

Andreas M. Luebke ◽

Jakob R. Izbicki ◽

...

Keyword(s):

Kidney Transplantation ◽

Pancreatic Ductal Adenocarcinoma ◽

Solid Organ Transplantation ◽

Multivisceral Resection ◽

Health Condition ◽

Ductal Adenocarcinoma ◽

Solid Organ ◽

Term Survival ◽

First Case ◽

Stage Renal Disease

Long-term survival in patients with pancreatic ductal adenocarcinoma (PDAC) is limited. Consequently, solid organ transplantation in PDAC patients is usually not considered. This is the first case report of kidney transplantation (KT) in a 57-year-old female patient after extended multivisceral resection for PDAC of the distal pancreas who had developed end-stage renal disease (ESRD) due to toxic kidney damage by chemotherapy. 13,5 years after initial PDAC-operation and 3 years after KT the patient remains in a good general health condition with sufficient function of the kidney allograft without local tumor recurrence or distant metastasis.

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