Structure investigation of sertraline drug and its iodine product using mass spectrometry, thermal analyses and MO-calculations

2007 ◽  
Vol 68 (3) ◽  
pp. 970-978 ◽  
Author(s):  
M.A. Zayed ◽  
M.F. Hawash ◽  
M.A. Fahmey ◽  
Abeer A. El-Habeeb
Keyword(s):  
Mass Spectrometry ◽  
Thermal Analyses ◽  
Structure Investigation ◽  
Mo Calculations

Structure investigation of mesalazine drug using thermal analyses, mass spectrometry, DFT calculations, and NBO analysis

2014 ◽  
Vol 117 (1) ◽  
pp. 463-471 ◽  
Author(s):  
Mostafa Y. Nassar ◽  
M. F. El-Shahat ◽  
S. M. Khalile ◽  
M. El-Desawy ◽  
Eman A. Mohamed
Keyword(s):  
Mass Spectrometry ◽  
Dft Calculations ◽  
Thermal Analyses ◽  
Nbo Analysis ◽  
Structure Investigation

Novel tetrazole PtII and PdII complexes with enhanced water solubility: synthesis, structural characterization and evaluation of antiproliferative activity

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Tatiyana V. Serebryanskaya ◽  
Alexander S. Lyakhov ◽  
Ludmila S. Ivashkevich ◽  
Yuri V. Grigoriev ◽  
Andreii S. Kritchenkov ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Performance ◽  
Water Solubility ◽  
Thermal Analyses ◽  
High Water ◽  
Acetonitrile Solution ◽  
X Ray ◽  
Molecular And Crystal Structures ◽  
Tetrazole Derivatives ◽  
High Water Solubility

AbstractNovel platinum(II) and palladium(II) chlorido complexes with tetrazole derivatives 1-(2-hydroxyethyl)tetrazole (het) and 1-[tris(hydroxymethyl)methyl]tetrazole (thm), viz. cis-[Pt(het)2Cl2], trans-[Pt(het)2Cl2], trans-[Pt(thm)2Cl2], trans-[Pd(het)2Cl2], and trans-[Pd(thm)2Cl2], were synthesized. The compounds were characterized by elemental and high-resolution electrospray ionization (HRESI) mass spectrometry, high-performance liquid chromatography (HPLC), 1H, 13C and 195Pt nuclear magnetic resonance (NMR) spectroscopy, thermal analyses, and Infrared (IR) spectroscopy. Molecular and crystal structures of trans-[PdL2Cl2] and trans-[PtL2Cl2] (L = het, thm) were established by single-crystal X-ray analysis. The complex cis-[Pt(het)2Cl2] was found to undergo cis–to–trans isomerization upon heating in acetonitrile solution and in the solid state. The synthesized complexes show rather high water solubility lying in the range of 2–10 mg/L.

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