In vivo gamma-aminobutyric acid and glutamate levels in people with first-episode schizophrenia: A proton magnetic resonance spectroscopy study

2018 ◽  
Vol 193 ◽  
pp. 295-303 ◽  
Author(s):  
P.W. Chiu ◽  
Simon S.Y. Lui ◽  
Karen S.Y. Hung ◽  
Raymond C.K. Chan ◽  
Queenie Chan ◽  
...  
Keyword(s):  
Proton Magnetic Resonance ◽  
Proton Magnetic Resonance Spectroscopy ◽  
Aminobutyric Acid ◽  
First Episode ◽  
Resonance Spectroscopy ◽  
Gamma Aminobutyric Acid ◽  
Spectroscopy Study ◽  
Magnetic Resonance Spectroscopy Study ◽  
First Episode Schizophrenia

scholarly journals Reducedγ-Aminobutyric Acid and Glutamate+Glutamine Levels in Drug-Naïve Patients with First-Episode Schizophrenia but Not in Those at Ultrahigh Risk

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Junjie Wang ◽  
Yingying Tang ◽  
Tianhong Zhang ◽  
Huiru Cui ◽  
Lihua Xu ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Proton Magnetic Resonance ◽  
Proton Magnetic Resonance Spectroscopy ◽  
Aminobutyric Acid ◽  
First Episode ◽  
Resonance Spectroscopy ◽  
Healthy Controls ◽  
Drug Naïve ◽  
First Episode Schizophrenia

Alteredγ-aminobutyric acid (GABA), glutamate (Glu) levels, and an imbalance between GABAergic and glutamatergic neurotransmissions have been involved in the pathophysiology of schizophrenia. However, it remains unclear how these abnormalities impact the onset and course of psychosis. In the present study, 21 drug-naïve subjects at ultrahigh risk for psychosis (UHR), 16 drug-naïve patients with first-episode schizophrenia (FES), and 23 healthy controls (HC) were enrolled. In vivo GABA and glutamate+glutamine (Glx) levels in the medial prefrontal cortex were measured using proton magnetic resonance spectroscopy. Medial prefrontal GABA and Glx levels in FES patients were significantly lower than those in HC and UHR, respectively. GABA and Glx levels in UHR were comparable with those in HC. In each group, there was a positive correlation between GABA and Glx levels. Reduced medial prefrontal GABA and Glx levels thus may play an important role in the early stages of schizophrenia.

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