Association between obesity and white matter microstructure impairments in patients with schizophrenia: A whole-brain magnetic resonance imaging study

2020 ◽  
Author(s):  
Shinsuke Hidese ◽  
Miho Ota ◽  
Junko Matsuo ◽  
Ikki Ishida ◽  
Yuuki Yokota ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
White Matter ◽  
Magnetic Resonance ◽  
Brain Magnetic Resonance Imaging ◽  
Imaging Study ◽  
Magnetic Resonance Imaging Study ◽  
Resonance Imaging ◽  
Whole Brain ◽  
White Matter Microstructure

scholarly journals Grey matter abnormalities in trichotillomania: morphometric magnetic resonance imaging study

2008 ◽  
Vol 193 (3) ◽  
pp. 216-221 ◽  
Author(s):  
Samuel R. Chamberlain ◽  
Lara A. Menzies ◽  
Naomi A. Fineberg ◽  
Natalia del Campo ◽  
John Suckling ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
White Matter ◽  
Magnetic Resonance ◽  
Affect Regulation ◽  
Grey Matter ◽  
Hippocampal Formation ◽  
Imaging Study ◽  
Resonance Imaging ◽  
Whole Brain ◽  
Axis I

BackgroundTrichotillomania (repetitive hair-pulling) is an Axis I psychiatric disorder whose neurobiological basis is incompletely understood. Whole-brain trichotillomania neuroimaging studies are lacking.AimsTo investigate grey and white matter abnormalities over the whole brain in patients with trichotillomania.MethodEighteen patients with DSM–IV trichotillomania and 19 healthy controls undertook structural magnetic resonance imaging after providing written informed consent. Differences in grey and white matter were investigated using computational morphometry.ResultsPatients with trichotillomania showed increased grey matter densities in the left striatum, left amygdalo-hippocampal formation, and multiple (including cingulate, supplementary motor, and frontal) cortical regions bilaterally.ConclusionsTrichotillomania was associated with structural grey matter changes in neural circuitry implicated in habit learning, cognition and affect regulation. These findings inform animal models of the disorder and highlight key regions of interest for future translational research.

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