scholarly journals Latent inhibition, aberrant salience, and schizotypy traits in cannabis users

2022 ◽  
Vol 28 ◽  
pp. 100235
Author(s):  
Christopher Dawes ◽  
Declan Quinn ◽  
Andrea Bickerdike ◽  
Cian O’Neill ◽  
Kiri T. Granger ◽  
...  
Keyword(s):  
Latent Inhibition ◽  
Aberrant Salience

The psychopharmacology of latent inhibition: A neural network approach

1997 ◽  
Author(s):  
Nestor A. Schmajuk ◽  
Catalin V. Buhusi ◽  
Jeffrey A. Gray
Keyword(s):  
Neural Network ◽  
Latent Inhibition ◽  
Network Approach ◽  
Neural Network Approach

LSD, madness and healing: Mystical experiences as possible link between psychosis model and therapy model

2021 ◽  
pp. 1-15
Author(s):  
Isabel Wießner ◽  
Marcelo Falchi ◽  
Fernanda Palhano-Fontes ◽  
Amanda Feilding ◽  
Sidarta Ribeiro ◽  
...  
Keyword(s):  
Therapeutic Potential ◽  
Five Facet Mindfulness Questionnaire ◽  
Psychotic Experience ◽  
Creative Imagination ◽  
Double Blind ◽  
Alteration Of Consciousness ◽  
Therapy Model ◽  
Aberrant Salience ◽  
Mystical Experiences ◽  
Meaning Attribution

Abstract Background For a century, psychedelics have been investigated as models of psychosis for demonstrating phenomenological similarities with psychotic experiences and as therapeutic models for treating depression, anxiety, and substance use disorders. This study sought to explore this paradoxical relationship connecting key parameters of the psychotic experience, psychotherapy, and psychedelic experience. Methods In a randomized, double-blind, placebo-controlled, crossover design, 24 healthy volunteers received 50 μg d-lysergic acid diethylamide (LSD) or inactive placebo. Psychotic experience was assessed by aberrant salience (Aberrant Salience Inventory, ASI), therapeutic potential by suggestibility (Creative Imagination Scale, CIS) and mindfulness (Five Facet Mindfulness Questionnaire, FFMQ; Mindful Attention Awareness Scale, MAAS; Experiences Questionnaire, EQ), and psychedelic experience by four questionnaires (Altered State of Consciousness Questionnaire, ASC; Mystical Experiences Questionnaire, MEQ; Challenging Experiences Questionnaire, CEQ; Ego-Dissolution Inventory, EDI). Relationships between LSD-induced effects were examined. Results LSD induced psychedelic experiences, including alteration of consciousness, mystical experiences, ego-dissolution, and mildly challenging experiences, increased aberrant salience and suggestibility, but not mindfulness. LSD-induced aberrant salience correlated highly with complex imagery, mystical experiences, and ego-dissolution. LSD-induced suggestibility correlated with no other effects. Individual mindfulness changes correlated with aspects of aberrant salience and psychedelic experience. Conclusions The LSD state resembles a psychotic experience and offers a tool for healing. The link between psychosis model and therapeutic model seems to lie in mystical experiences. The results point to the importance of meaning attribution for the LSD psychosis model and indicate that psychedelic-assisted therapy might benefit from therapeutic suggestions fostering mystical experiences.

Obsessive–compulsive disorder patients display enhanced latent inhibition on a visual search task

2006 ◽  
Vol 44 (8) ◽  
pp. 1137-1145 ◽  
Author(s):  
Oren Kaplan ◽  
Reuven Dar ◽  
Lirona Rosenthal ◽  
Haggai Hermesh ◽  
Mendel Fux ◽  
...  
Keyword(s):  
Visual Search ◽  
Obsessive Compulsive Disorder ◽  
Latent Inhibition ◽  
Search Task ◽  
Visual Search Task ◽  
Obsessive Compulsive ◽  
Compulsive Disorder
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