scholarly journals Pneumocystis jirovecii pneumonia (PJP) prophylaxis patterns among patients with rheumatic diseases receiving high-risk immunosuppressant drugs

2019 ◽  
Vol 48 (6) ◽  
pp. 1087-1092 ◽  
Author(s):  
Gabriela Schmajuk ◽  
Kashif Jafri ◽  
Michael Evans ◽  
Stephen Shiboski ◽  
Milena Gianfrancesco ◽  
...  
Keyword(s):  
High Risk ◽  
Rheumatic Diseases ◽  
Pneumocystis Jirovecii ◽  
Pneumocystis Jirovecii Pneumonia

scholarly journals Pneumocystis jirovecii Pneumonia in Patients with Rheumatic Diseases: Risk Assessment and Prophylaxis

2022 ◽  
pp. 1-7
Author(s):  
Matthew Shing Him Lee ◽  
Shirley Chiu Wai Chan
Keyword(s):  
Risk Factors ◽  
Risk Assessment ◽  
Rheumatic Diseases ◽  
Immunosuppressive Agents ◽  
Pneumocystis Jirovecii ◽  
Pneumocystis Jirovecii Pneumonia ◽  
International Guideline ◽  
Related Factors ◽  
Factors Associated ◽  
Disease Specific

Pneumocystis jirovecii pneumonia (PJP) is an uncommon opportunistic infection in patients with rheumatic diseases with high mortality. Unlike other non-HIV conditions, international guideline for PJP prophylaxis in rheumatic diseases is currently lacking. Recent evidence regarding the risk of PJP and effectiveness of prophylaxis has been accumulating. This Review provides an update on the information about risk factors associated with PJP in patients with rheumatic diseases based on rheumatic diagnoses, use of immunosuppressive agents and other disease-related factors. The second part of the article summarizes evidence regarding the effectiveness of PJP prophylaxis by considering both disease-related and therapy-related factors. Finally, the Review outlined the currently available disease-specific recommendations and local guidelines, and appreciate the factors that influence physicians’ decision.

scholarly journals Point-Counterpoint: Should Serum β-d-Glucan Testing Be Used for the Diagnosis of Pneumocystis jirovecii Pneumonia?

2019 ◽  
Vol 58 (1) ◽  
Author(s):  
Gabriela Corsi-Vasquez ◽  
Luis Ostrosky-Zeichner ◽  
Edward F. Pilkington ◽  
Paul E. Sax
Keyword(s):  
High Risk ◽  
Prophylactic Antibiotics ◽  
Induced Sputum ◽  
Pneumocystis Jirovecii ◽  
Outpatient Clinics ◽  
Pneumocystis Jirovecii Pneumonia ◽  
Immunocompromised Patients ◽  
Content Type ◽  
Aids Epidemic

Despite the widespread use of prophylactic antibiotics in high-risk individuals, Pneumocystis jirovecii remains an important cause of pneumonia in immunocompromised patients. During the peak of the AIDS epidemic, many hospitals and outpatient clinics were very proficient at collecting induced sputum specimens for the diagnosis of Pneumocystis jirovecii pneumonia (PJP).

scholarly journals Prevalence and Genotyping of Pneumocystis jirovecii Pneumonia in Patients with Previously Untreated Acute Myeloid Leukemia

2021 ◽  
Vol 5 (1) ◽  
pp. 3
Author(s):  
Valentina Del Prete ◽  
Giovangiacinto Paterno ◽  
David Di Cave ◽  
Luca Guarnera ◽  
Raffaele Palmieri ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
High Risk ◽  
Bronchoalveolar Lavage ◽  
Myeloid Leukemia ◽  
Pneumocystis Jirovecii ◽  
Pneumocystis Jirovecii Pneumonia ◽  
Immunocompromised Patients ◽  
Genotype 1 ◽  
Genotype 3 ◽  
Acute Myeloid

Pneumocystis jirovecii pneumonia (PJP) is an opportunistic infection affecting immunocompromised patients. Patients with acute myeloid leukemia (AML) are not considered at high risk of PJP, thus, prophylaxis is not recommended. Between 2010 and 2020 we retrospectively analyzed 251 AML patients. We performed molecular diagnosis and genotyping of Pneumocystis jirovecii in 67 bronchoalveolar lavage samples. Eleven cases of PJP were diagnosed, with a prevalence of 4.3%. Our study confirms that the most widespread genotype in Europe is genotype 1; in our patients, 70% presented with genotype 1 and 30% the genotype 3.

scholarly journals Risk Factors of Pneumocystis jirovecii Pneumonia in Patients with Rheumatic Diseases

2019 ◽  
Vol 20 (-1) ◽  
pp. 122-122
Author(s):  
Imren Nesil ◽  
◽  
Pervin Korkmaz Ekren ◽  
Figen Yargucu Zihni ◽  
Adnan Yuksel Guruz ◽  
...  
Keyword(s):  
Risk Factors ◽  
Rheumatic Diseases ◽  
Pneumocystis Jirovecii ◽  
Pneumocystis Jirovecii Pneumonia
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