The Role of Focal Liver Ablation in the Treatment of Unresectable Primary and Secondary Malignant Liver Tumors

Background: The aim of the study is evaluation of the possible role of the scintigraphic estimation of the relative liver perfusion in diagnosis and the choice of treatment of liver carcinomas. Material and methods: Hepatic perfusion index was obtained by dynamic scintigraphy in 126 patients. Results: In the control group values did not differ from the value in the patients with benign tumors (p>0.05). However, in hepatocellular carcinoma and liver metastases of different tumors, HPI values were significantly decreased in comparison to controls and benign tumors (p<0.01), but they didn?t differ between themselves (p>0.05). The values were especially low in the patients with malignant diseases in the liver accosciated with vascular disturbances in the portal system. Conclusion: HRA could be easily done during the different conventional nuclear medicine methods. It can be an useful method for the assessment of different degrees of hemodynamic alterations in portal system, for differential diagnosis of benign and malignant liver tumors, as well as for assessment of the liver tissue and tumor perfusion, which might be helpful in the decision making for the undertaking of intraarterial (radionuclide, chemotherapy etc.) therapy.

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Malignant Liver Tumors in Childhood

Cancer in Childhood ◽

10.1007/978-1-4684-2070-8_22 ◽

1973 ◽

pp. 166-170

Author(s):

Sigmund H. Ein ◽

Clinton A. Stephens

Keyword(s):

Liver Tumors ◽

Malignant Liver Tumors ◽

Malignant Liver

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Horizons of development of immunotherapy for malignant liver tumors

Experimental and Clinical Gastroenterology ◽

10.31146/1682-8658-ecg-191-7-81-89 ◽

2021 ◽

pp. 81-89

Author(s):

V. E. Mukhin ◽

Yu. S. Konstantinova ◽

R. R. Gimadiev ◽

N. V. Mazurchik

Keyword(s):

Liver Tumors ◽

Surgical Excision ◽

Malignant Neoplasms ◽

Therapeutic Approaches ◽

Liver Malignancies ◽

Primary Liver Tumors ◽

Malignant Liver Tumors ◽

Malignant Liver ◽

Methods Of Treatment ◽

New Strategies

Primary liver tumors are one of the most common types of malignant neoplasms. Surgical excision is still the most effective treatment in the early stages of the disease, however in most cases early diagnosis is difficult. Moreover, even if the treatment is carried out according to a radical program, the risk of relapse remains extremely high. In this regard, the search for new strategies for the treatment of liver malignancies that differ from traditional methods of treatment is not terminated. One of such promising approaches is immunotherapy. The present review is devoted to the current understanding of the mechanisms of action and the available clinical experience in the use of immunotherapy approaches in the treatment of liver malignancies. Combining different types of immunotherapy or combining immunotherapy with traditional therapeutic approaches can facilitate a synergistic effect and contribute to the development of personalized medicine.

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