scholarly journals CORAL: Building up QSAR models for the chromosome aberration test

2019 ◽  
Vol 26 (6) ◽  
pp. 1101-1106 ◽  
Author(s):  
Andrey A. Toropov ◽  
Alla P. Toropova ◽  
Giuseppa Raitano ◽  
Emilio Benfenati
Keyword(s):  
Chromosome Aberration ◽  
Qsar Models ◽  
Chromosome Aberration Test

Genotoxicity Studies on Sel-Plex®, a Standardized, Registered High-Selenium Yeast

2006 ◽  
Vol 25 (6) ◽  
pp. 477-485 ◽  
Author(s):  
James C. Griffiths ◽  
Ray A. Matulka ◽  
Ronan Power
Keyword(s):  
Chromosome Aberration ◽  
Micronucleus Test ◽  
Mutagenic Activity ◽  
Human Lymphocytes ◽  
Selenium Yeast ◽  
Yeast Saccharomyces Cerevisiae ◽  
Reverse Mutation ◽  
High Selenium ◽  
Chromosome Aberration Test

Selenium, recognized as an essential nutrient for human health, is a component of proteins and enzymes required for various biological functions and is currently being used as a feed supplement for livestock in geographical areas that are naturally low in selenium. Selenium is structurally similar to sulfur, replacing the sulfur atom in stoichiometric amounts and thus functions through an association with proteins, termed selenoproteins. In geographic areas low in selenium, there is the potential for animals (including humans) to become selenium deficient and this potential deficiency can be remedied by consumption of exogenous selenium, including selenium-enriched yeast ( Saccharomyces cerevisiae) that contains high levels of organic selenium (e.g., selenized yeast). A unique, standardized, registered high selenium food-grade baker’s yeast ( S. cerevisiae; Sel-Plex®), was tested in the following battery of Genotoxicity assays; (1) a bacterial reverse mutation test (Ames test); (2) an in vitro mammalian chromosome aberration test; and (3) a mouse micronucleus test. Under the conditions of this assay, Sel-Plex® showed no evidence of mutagenic activity in Salmonella typhimurium, in the bacterial reverse mutation test. Sel-Plex® did not induce significant chromosomal aberrations in cultured human lymphocytes in the in vitro mammalian chromosome aberration test. Sel-Plex® did not statistically increase the frequency or proportion of micronucleated immature erythrocytes in the mouse micronucleus test. Thus, from the studies presented here, the authors conclude that Sel-Plex® is nongenotoxic.

scholarly journals MUTAGENICITY STUDY OF GADOBENATE DIMEGLUMINE FORMULATION (E7155) (2) : CHROMOSOME ABERRATION TEST WITH HUMAN LYMPHOCYTES IN CULTURE

1999 ◽  
Vol 24 (SupplementI) ◽  
pp. 95-101 ◽  
Author(s):  
Naoki TORITSUKA ◽  
Hirohiko DAIMON ◽  
Shigeki SAWADA ◽  
Fumio SAGAMI ◽  
Piero TIRONE ◽  
...  
Keyword(s):  
Chromosome Aberration ◽  
Human Lymphocytes ◽  
Gadobenate Dimeglumine ◽  
Chromosome Aberration Test

Genotoxicity evaluation of dental restoration nanocomposite using comet assay and chromosome aberration test

2012 ◽  
Vol 24 (1) ◽  
pp. 015105 ◽  
Author(s):  
Marahaini Musa ◽  
Kannan Thirumulu Ponnuraj ◽  
Dasmawati Mohamad ◽  
Ismail Ab Rahman
Keyword(s):  
Comet Assay ◽  
Chromosome Aberration ◽  
Dental Restoration ◽  
Chromosome Aberration Test

Evaluation on Biocompatibility of Materials of Goose-Head Nail Steel Plates

2012 ◽  
Vol 442 ◽  
pp. 71-75
Author(s):  
Ming Gao ◽  
Qing Fang Liu ◽  
Yao Zhao
Keyword(s):  
Chromosome Aberration ◽  
Ames Test ◽  
Local Reaction ◽  
Steel Plates ◽  
Reaction Test ◽  
Irritation Test ◽  
Test Materials ◽  
Chromosome Aberration Test

Aim of this study was to detect biocompatibility of the materials of goose-head nail steel plates, so as to evaluate the safety of these kind of materials. We combined sensitization test,intracutaneous irritation test,chromosome aberration test,Ames test and a local reaction test after implantation to evaluate the biocompatibility of the test samples. The results suggest that the test samples have no sensitization, no intracutaneous irritation, no genotoxicity in chromosome aberration test and Ames test. Materials of Goose-head Nail Steel Plates are biologically safe and could be generalized for clinic application.

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