Bone mineral density in women 12 months after bariatric surgery: Comparison between laparoscopic sleeve gastrectomy, gastric bypass and sleeve gastrectomy with jejunal bypass.

2015 ◽  
Vol 11 (6) ◽  
pp. S77
Author(s):  
Matias Sepulveda ◽  
Yudith Preiss ◽  
Santiago Ximena Prat ◽  
Andrea Morales
2013 ◽  
Vol 23 (12) ◽  
pp. 2086-2091 ◽  
Author(s):  
Nuria Vilarrasa ◽  
Amador G. Ruiz de Gordejuela ◽  
Carmen Gómez-Vaquero ◽  
Jordi Pujol ◽  
Iñaki Elio ◽  
...  

Author(s):  
Tair Ben-Porat ◽  
Shiraz Peretz ◽  
Amihai Rottenstreich ◽  
Ram Weiss ◽  
Auryan Szalat ◽  
...  

2015 ◽  
Vol 23 ◽  
pp. 101-107 ◽  
Author(s):  
Piotr Adamczyk ◽  
Marek Bužga ◽  
Pavol Holéczy ◽  
Zdeněk Švagera ◽  
Vít Šmajstrla ◽  
...  

Author(s):  
Dag Hofsø ◽  
Thor Olav Widerøe Hillestad ◽  
Erling Halvorsen ◽  
Farhat Fatima ◽  
Line Kristin Johnson ◽  
...  

Abstract Context Bariatric surgery, particularly Roux-en-Y gastric bypass (RYGB), is associated with an increased risk of osteoporotic fractures. It is unknown whether RYGB or sleeve gastrectomy (SG) have different effects on bone health. Objective To compare changes in bone mineral density and markers of bone turnover 1 year after SG and RYGB. Design, Setting, Patients, and Interventions Randomized, triple-blind, single-center trial at a tertiary care center in Norway. The primary outcome was diabetes remission. Patients with severe obesity and type 2 diabetes were randomized and allocated (1:1) to SG or RYGB. Main Outcome Measures Changes in areal bone mineral density (aBMD) and bone turnover markers. Results Femoral neck, total hip, and lumbar spine aBMD, but not total body aBMD, decreased significantly more after RYGB (n = 44) than after SG (n = 48) (mean [95% confidence interval] between group differences -2.8% [-4.7 to -0.8], -3.0% [-5.0 to -0.9], -4.2% [-6.4 to -2.1], and -0.5% [-1.6 to 0.6], respectively). The increase in procollagen type 1 N-terminal propeptide (P1NP) and C-telopeptide of type I collagen (CTX-1) were approximately 100% higher after RYGB than after SG (between group difference at 1 year, both P < 0.001). The changes in femoral neck, total hip, and lumbar spine aBMDs and the changes in P1NP and CTX-1 were independently associated with the surgical procedure (all P < 0.05) and not weight change. Conclusions Roux-en-Y gastric bypass was associated with a greater reduction in aBMD and a greater increase in bone turnover markers compared with SG. This finding could suggest greater skeletal fragility after RYGB.


Author(s):  
Alexandra Krez ◽  
Sanchita Agarwal ◽  
Mariana Bucovsky ◽  
Donald J McMahon ◽  
Yizhong Hu ◽  
...  

Abstract Context The prevalence of obesity is burgeoning among African American and Latina women; however, few studies investigating the skeletal effects of bariatric surgery have focused on these groups. Objective To investigate long-term skeletal changes following Roux-en-Y gastric bypass (RYGB) in African American and Latina women. Design Four-year prospective cohort study. Patients African American and Latina women presenting for RYGB (n = 17, mean age 44, body mass index 44 kg/m2) were followed annually for 4 years postoperatively. Main Outcome Measures Dual-energy x-ray absorptiometry (DXA) measured areal bone mineral density (aBMD) at the spine, hip, and forearm, and body composition. High-resolution peripheral quantitative computed tomography measured volumetric bone mineral density (vBMD) and microarchitecture. Individual trabecula segmentation-based morphological analysis assessed trabecular morphology and connectivity. Results Baseline DXA Z-Scores were normal. Weight decreased ~30% at Year 1, then stabilized. Parathyroid hormone (PTH) increased by 50% and 25-hydroxyvitamin D was stable. By Year 4, aBMD had declined at all sites, most substantially in the hip. There was significant, progressive loss of cortical and trabecular vBMD, deterioration of microarchitecture, and increased cortical porosity at both the radius and tibia over 4 years. There was loss of trabecular plates, loss of axially aligned trabeculae, and decreased trabecular connectivity. Whole bone stiffness and failure load declined. Risk factors for bone loss included greater weight loss, rise in PTH, and older age. Conclusions African American and Latina women had substantial and progressive bone loss, deterioration of microarchitecture, and trabecular morphology following RYGB. Further studies are critical to understand the long-term skeletal consequences of bariatric surgery in this population.


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