Does Adolescent Obesity affect Surgical Presentation and Radiographic Outcome for Patients with AIS?

2015 ◽  
Vol 15 (10) ◽  
pp. S214-S215
Author(s):  
Benjamin T. Bjerke ◽  
Rehan Saiyed ◽  
Zoe Cheung ◽  
Grant Shifflett ◽  
Matthew E. Cunningham
2017 ◽  
Vol 26 (1) ◽  
pp. 53-58 ◽  
Author(s):  
Benjamin T. Bjerke ◽  
Rehan Saiyed ◽  
Zoe B. Cheung ◽  
Tyler J. Uppstrom ◽  
Grant D. Shifflett ◽  
...  

2009 ◽  
Vol 42 (20) ◽  
pp. 52
Author(s):  
SALLY KOCH KUBETIN
Keyword(s):  

Children ◽  
2021 ◽  
Vol 8 (3) ◽  
pp. 196
Author(s):  
Ioanna Maligianni ◽  
Christos Yapijakis ◽  
Flora Bacopoulou ◽  
George Chrousos

Child and adolescent obesity constitute one of the greatest contemporary public health menaces. The enduring disproportion between calorie intake and energy consumption, determined by a complex interaction of genetic, epigenetic, and environmental factors, finally leads to the development of overweight and obesity. Child and adolescent overweight/obesity promotes smoldering systemic inflammation (“para-inflammation”) and increases the likelihood of later metabolic and cardiovascular complications, including metabolic syndrome and its components, which progressively deteriorate during adulthood. Exosomes are endosome-derived extracellular vesicles that are secreted by a variety of cells, are naturally taken-up by target cells, and may be involved in many physiological and pathological processes. Over the last decade, intensive research has been conducted regarding the special role of exosomes and the non-coding (nc) RNAs they contain (primarily micro (mi) RNAs, long (l) non-coding RNAs, messenger (m) RNAs and other molecules) in inter-cellular communications. Through their action as communication mediators, exosomes may contribute to the pathogenesis of obesity and associated disorders. There is increasing evidence that exosomal miRNAs and lncRNAs are involved in pivotal processes of adipocyte biology and that, possibly, play important roles in gene regulation linked to human obesity. This review aims to improve our understanding of the roles of exosomes and their cargo in the development of obesity and related metabolic and inflammatory disorders. We examined their potential roles in adipose tissue physiology and reviewed the scarce data regarding the altered patterns of circulating miRNAs and lncRNAs observed in obese children and adolescents, compared them to the equivalent, more abundant existing findings of adult studies, and speculated on their proposed mechanisms of action. Exosomal miRNAs and lncRNAs could be applied as cardiometabolic risk biomarkers, useful in the early diagnosis and prevention of obesity. Furthermore, the targeting of crucial circulating exosomal cargo to tissues involved in the pathogenesis and maintenance of obesity could provide a novel therapeutic approach to this devastating and management-resistant pandemic.


2021 ◽  
pp. 175857322098785
Author(s):  
Aparna Viswanath ◽  
Jill L Thomas ◽  
Adam C Watts

The coronoid is one of the elbow’s primary static stabilisers, and the importance of reconstruction following fracture with instability has been established. In the developing elbow, instability can lead to greater sigmoid notch dysplasia that can make reconstruction challenging. A novel technique to improve osseous stability with an opening wedge ‘stamp osteotomy’ reconstruction of the coronoid is described combined with a lateral ligament reconstruction, in two patients with recurrent posteromedial rotatory instability. The technique improves congruity and coverage of the greater sigmoid notch with the trochlea whilst maintaining articular cartilage. Extra-articular iliac crest bone graft is used to maintain the position with buttress plate support. The surgical technique is described and the clinical and radiographic outcome reported in two patients. Level of evidence: IV.


Author(s):  
Liliana Artaza ◽  
Andrea Campello ◽  
Giuliana Soimu ◽  
Flávio R. F. Alves ◽  
Isabela N. Rôças ◽  
...  

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