P50. Effect of systemic teriparatide (PTH1-34) versus placebo on bone mineral density (BMD) after lumbar spinal arthrodesis

Abstract Background: Lumbar spinal stenosis (LSS) can cause various neurological symptoms and reduce the daily activity of patients. Many studies have shown that free physical activities and exercise can improve bone mineral density (BMD) in patients with osteoporosis. However, the effect of LSS on BMD has not been reported. The purpose of this study was to investigate the effects of LSS on BMD in patients treated with ibandronate for newly diagnosed osteoporosis.Methods: Group 1 included 83 patients with osteoporosis alone, and group 2 included 76 patients with both osteoporosis and symptomatic LSS. We confirmed four BMD values presented as T-score at initial, and 1-, 2-, and 3-year follow-ups. Mean BMD and annual changes of BMD for three years were compared between the two groups. Correlations between initial BMD and total change of BMD were also analyzed in both groups.Results: Mean annual BMDs were significantly higher in group 1 compared than in group 2 (-3.39 vs. -3.58 at 1-year; -3.27 vs. -3.49 at 2-year; -3.13 vs. -3.45 at 3-year; all p < 0.05). Annual change of BMD at 1-year follow-up (0.32 vs. 0.21, p = 0.036) and total change of BMD for three years (0.57 vs. 0.35, p = 0.002) were significantly higher in group 1. Group 1 had a strong negative correlation (r = -0.511, P = 0.000) between initial BMD and total change of BMD, whereas group 2 showed a weak negative correlation (r = -0.247, p = 0.032).Conclusions: Symptomatic LSS may interfere with BMD improvement in the treatment of osteoporosis with ibandronate. Active treatment for LSS with more potent treatment for osteoporosis should be taken to increase BMD for patients with osteoporosis and LSS.

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Serum sclerostin levels positively correlate with lumbar spinal bone mineral density in postmenopausal women—the six-month effect of risedronate and teriparatide

Osteoporosis International ◽

10.1007/s00198-010-1525-6 ◽

2011 ◽

Vol 23 (3) ◽

pp. 1171-1176 ◽

Cited By ~ 72

Author(s):

S. A. Polyzos ◽

A. D. Anastasilakis ◽

C. Bratengeier ◽

W. Woloszczuk ◽

A. Papatheodorou ◽

...

Keyword(s):

Bone Mineral Density ◽

Postmenopausal Women ◽

Bone Mineral ◽

Spinal Bone Mineral Density ◽

Mineral Density ◽

Lumbar Spinal

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Measurement of Lumbar Spinal Bone Mineral Density in Preterm Infants by Dual-Energy X-Ray Absorptiometry

Neonatology ◽

10.1159/000243978 ◽

1993 ◽

Vol 64 (2-3) ◽

pp. 96-103 ◽

Cited By ~ 29

Author(s):

Hirokazu Tsukahara ◽

Masakatsu Sudo ◽

Minoru Umezaki ◽

Yasushi Fujii ◽

Masanori Kuriyama ◽

...

Keyword(s):

Bone Mineral Density ◽

Preterm Infants ◽

Bone Mineral ◽

Dual Energy ◽

Spinal Bone Mineral Density ◽

Mineral Density ◽

X Ray ◽

Lumbar Spinal

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Comparison of the osteogenic effects between two surface interferential stimulation devices to enhance surgically based spinal fusion

Veterinary and Comparative Orthopaedics and Traumatology ◽

10.1055/s-0038-1632792 ◽

2004 ◽

Vol 17 (01) ◽

pp. 41-47

Author(s):

S. A. Martinez ◽

L. V. Smith ◽

W. J. Carroll ◽

J. A. Zimmermann ◽

M. S. Shih ◽

...

Keyword(s):

Bone Mineral Density ◽

Spinal Fusion ◽

Bone Mineral ◽

Controlled Study ◽

Control Group ◽

Lumbar Spinal Fusion ◽

Fusion Model ◽

Mineral Density ◽

Disc Space ◽

Lumbar Spinal

SummaryIn human medicine, lumbar spinal fusion procedures for chronic degenerative conditions have significant failure rates leading to the formation of pseudoarthroses. Adjunct procedures including the use of electrical stimulation devices have been developed in animal models, and utilized in human clinical cases, in an attempt to reduce the incidence of nonunion. A randomized, controlled study was performed to compare the effects of two surface interferential stimulation devices (SIS) on a rabbit lumbar spinal fusion model. Twenty-five rabbits underwent bilateral intertransverse process arthrodesis at the L2-L3 disc space. The rabbits were divided into five groups: one control group receiving sham stimulation, and four treatment groups receiving interferential stimulation from one of two devices (RS4i at 13.3 mA, RS4i at 15.8 mA, RS4v at 11.6 mA, and RS4v at 14.8 mA). Dual energy X-ray absorptiometry analyses (DXA) were performed and at 2 week intervals to evaluate fusion site bone mineral density. All rabbits were euthanitized at eight weeks and fusion sites were evaluated for biomechanical strength and histomorphometric properties. There was not any difference in bone mineral density between the groups during the eight week test period. The uniaxial tension tests evaluating maximum load to failure, stiffness, and energy absorbed also resulted in no statistical differences between the groups. The RS4i device at 15.8 mA yielded an increased amount of lamellar bone compared to the control group (p = 0.02). The RS4v device at 11.6 mA resulted in less total bone than the control group (p = 0.04).

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Does Unilateral Lumbosacral Radiculopathy Affect the Association between Lumbar Spinal Muscle Morphometry and Bone Mineral Density?

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph182413155 ◽

2021 ◽

Vol 18 (24) ◽

pp. 13155

Author(s):

Minjung Kim ◽

Jinmann Chon ◽

Seung Ah Lee ◽

Yunsoo Soh ◽

Myung Chul Yoo ◽

...

Keyword(s):

Bone Mineral Density ◽

Lumbar Spine ◽

Muscle Mass ◽

Bone Mineral ◽

Pearson Correlation ◽

Erector Spinae ◽

Mineral Density ◽

Lumbosacral Radiculopathy ◽

Lumbar Spinal ◽

Spinal Muscles

Age-related degenerative changes lead to a gradual decrease in bone mineral density (BMD) and muscle mass. We aimed to assess the effects of decreased BMD and lumbar denervation on lumbar spinal muscle morphometry and the relationship between BMD and lumbar spinal muscular morphometry, respectively. Eighty-one patients, aged 50–85 years, diagnosed with unilateral lumbosacral radiculopathy based on electrodiagnostic studies between January 2016 and April 2021 were enrolled. BMD T scores in the lumbar spine and hip were measured using dual-energy X-ray absorptiometry. The cross-sectional area (CSA) of the psoas, multifidus, and erector spinae located in the middle of the lumbar spine, between the L3 and L4 and between the L4 and L5 levels, respectively, was measured using axial MRI. Functional CSA (FCSA) was defined as the CSA of lean muscle mass. Pearson correlation analyses were performed to evaluate the association between BMD T scores and the CSA, FCSA, and the ratio of the FCSA to the CSA (functional ratio) for each side. The CSA of lumbar spinal muscles showed no significant correlation with lumbar BMD. The FCSA and functional ratio of lumbar spinal muscles were significantly correlated with lumbar BMD. There was no correlation between femur BMD and lumbar spinal muscle morphometry.

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