scholarly journals The Structure of a Two-Disulfide Intermediate Assists in Elucidating the Oxidative Folding Pathway of a Cyclic Cystine Knot Protein

Structure ◽  
2008 ◽  
Vol 16 (6) ◽  
pp. 842-851 ◽  
Author(s):  
Maša Cemazar ◽  
Ajinkya Joshi ◽  
Norelle L. Daly ◽  
Alan E. Mark ◽  
David J. Craik
Keyword(s):  
Folding Pathway ◽  
Oxidative Folding ◽  
Cystine Knot ◽  
Cystine Knot Protein

Oxidative Folding of the Cystine Knot Motif in Cyclotide Proteins

2005 ◽  
Vol 12 (2) ◽  
pp. 147-152 ◽  
Author(s):  
David Craik ◽  
Norelle Daly
Keyword(s):  
Oxidative Folding ◽  
Cystine Knot

High level expression of the Drosophila Toll receptor ectodomain and crystallization of its complex with the morphogen Spätzle

2013 ◽  
Vol 394 (8) ◽  
pp. 1091-1096 ◽  
Author(s):  
Marco Stelter ◽  
Uwe Fandrich ◽  
Kati Franzke ◽  
Angelika Schierhorn ◽  
Constanze Breithaupt ◽  
...  
Keyword(s):  
Immune Response ◽  
High Level Expression ◽  
Receptor Ligand ◽  
High Affinity ◽  
Cystine Knot ◽  
Toll Receptor ◽  
Cystine Knot Protein ◽  
High Yields ◽  
High Level ◽  
Affinity Interaction

Abstract Drosophila Toll receptors are involved in embryonic development and in the immune response of adult flies. In both processes, the Toll receptor ligand is the NGF-like cystine knot protein Spätzle. Here we present the expression of Toll receptor ectodomain in Schneider cells at high yields and demonstrate a high affinity interaction with the refolded and trypsin-processed Spätzle cystine knot domain dimer. Poorly and anisotropically diffracting crystals of the complex could be improved by deglycosylation and dehydration, paving the way for structural analyses of the Toll-Spätzle interaction.

scholarly journals The Mitochondrial Intermembrane Space Oxireductase Mia40 Funnels the Oxidative Folding Pathway of the CytochromecOxidase Assembly Protein Cox19

2014 ◽  
Vol 289 (14) ◽  
pp. 9852-9864 ◽  
Author(s):  
Hugo Fraga ◽  
Joan-Josep Bech-Serra ◽  
Francesc Canals ◽  
Gabriel Ortega ◽  
Oscar Millet ◽  
...  
Keyword(s):  
Folding Pathway ◽  
Intermembrane Space ◽  
Oxidative Folding ◽  
Mitochondrial Intermembrane Space

Assessing the Magnitude of Folding Forces along the Oxidative Folding Pathway of Multi-Disulfide-Containing Proteins

2003 ◽  
Vol 125 (52) ◽  
pp. 16184-16185 ◽  
Author(s):  
Mahesh Narayan ◽  
Guoqiang Xu ◽  
Suzanne K. Schultz ◽  
Harold A. Scheraga
Keyword(s):  
Folding Pathway ◽  
Oxidative Folding

Structural basis of BMP signalling inhibition by the cystine knot protein Noggin

Nature ◽  
2002 ◽  
Vol 420 (6916) ◽  
pp. 636-642 ◽  
Author(s):  
Jay Groppe ◽  
Jason Greenwald ◽  
Ezra Wiater ◽  
Joaquin Rodriguez-Leon ◽  
Aris N. Economides ◽  
...  
Keyword(s):  
Structural Basis ◽  
Cystine Knot ◽  
Cystine Knot Protein ◽  
Bmp Signalling

scholarly journals Plasticity in the Oxidative Folding Pathway of the High Affinity Nerita Versicolor Carboxypeptidase Inhibitor (NvCI)

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Sebastián A. Esperante ◽  
Giovanni Covaleda ◽  
Sebastián A. Trejo ◽  
Sílvia Bronsoms ◽  
Francesc X. Aviles ◽  
...  
Keyword(s):  
Folding Pathway ◽  
Oxidative Folding ◽  
High Affinity ◽  
Carboxypeptidase Inhibitor

scholarly journals Dissecting the Oxidative Folding of Circular Cystine Knot Miniproteins

2009 ◽  
Vol 11 (5) ◽  
pp. 971-980 ◽  
Author(s):  
Sunithi Gunasekera ◽  
Norelle L. Daly ◽  
Richard J. Clark ◽  
David J. Craik
Keyword(s):  
Oxidative Folding ◽  
Cystine Knot

scholarly journals Selecting highly structure-specific antibodies using structured synthetic mimics of the cystine knot protein sclerostin

2012 ◽  
Vol 25 (5) ◽  
pp. 251-259 ◽  
Author(s):  
J. W. Back ◽  
C. Frisch ◽  
K. Van Pee ◽  
V. Boschert ◽  
R. van Vught ◽  
...  
Keyword(s):  
Specific Antibodies ◽  
Cystine Knot ◽  
Cystine Knot Protein

Intracellular Folding Pathway of the Cystine Knot-Containing Glycoprotein Hormone α-Subunit†

Biochemistry ◽  
2001 ◽  
Vol 40 (2) ◽  
pp. 577-585 ◽  
Author(s):  
Ryan J. Darling ◽  
Jason A. Wilken ◽  
Raymond W. Ruddon ◽  
Elliott Bedows
Keyword(s):  
Folding Pathway ◽  
Glycoprotein Hormone ◽  
Α Subunit ◽  
Cystine Knot

The race-specific elicitor AVR9 of the tomato pathogen Cladosporium fulvum : a cystine knot protein

FEBS Letters ◽  
1997 ◽  
Vol 404 (2-3) ◽  
pp. 153-158 ◽  
Author(s):  
Jacques Vervoort ◽  
Henno W van den Hooven ◽  
Axel Berg ◽  
Paul Vossen ◽  
Ralph Vogelsang ◽  
...  
Keyword(s):  
Cladosporium Fulvum ◽  
Cystine Knot ◽  
Cystine Knot Protein ◽  
Tomato Pathogen
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