Representing experimental solubility of phenylephrine hydrochloride in supercritical carbon dioxide and modeling solute solubility using semi-empirical correlations

2013 ◽  
Vol 75 ◽  
pp. 181-186 ◽  
Author(s):  
Hamid Rajaei ◽  
Ali Zeinolabedini Hezave ◽  
Mostafa Lashkarbolooki ◽  
Feridun Esmaeilzadeh
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Empirical Correlations ◽  
Phenylephrine Hydrochloride ◽  
Experimental Solubility ◽  
Semi Empirical ◽  
Supercritical Carbon

Solubility of the Ketoconazole (an Antifungal Drug) in Supercritical Carbon Dioxide and Menthol as a Cosolvent (Ternary System): Experimental Data and Empirical Correlations

2021 ◽  
Author(s):  
Gholamhossein Sodeifian ◽  
Seyed Ali Sajadian ◽  
Fariba Razmimanesh ◽  
Seyed Mojtaba Hazaveie
Keyword(s):  
Experimental Data ◽  
Carbon Dioxide ◽  
Binary System ◽  
Supercritical Carbon Dioxide ◽  
Ternary System ◽  
Drug Solubility ◽  
Analysis Method ◽  
Empirical Correlations ◽  
Semiempirical Models ◽  
Supercritical Carbon

Abstract One of the main steps in choosing the drug nanoparticle production processes by supercritical carbon dioxide (SC-CO2) is determining the solubility of the solid solute. For this purpose, the solubility of Ketoconazole (KTZ) in the SC-CO2, binary system, as well as in the SC-CO2-menthol (cosolvent), ternary system, was measured at 308–338 K and 12–30 MPa using the static analysis method. The KTZ solubility in the SC-CO2 ranged between 1.70×10− 6 and 8.02×10− 4, while drug solubility in the SC-CO2 with cosolvent varied from 2.7×10− 5 to 1.96×10− 4. This difference indicated the significant effect of menthol cosolvent on KTZ solubility in the SC-CO2. Moreover, KTZ solubilities in the two systems were correlated by several empirical and semiempirical models. Among them, Sodeifian et al., Bian et al., MST, and Bartle et al. models can more accurately correlate experimental data for the binary system than other used models. Also, the Sodeifian and Sajadian model well fitted the solubility data of the ternary system with AARD,%= 6.45, Radj= 0.995.

Experimental Solubility Measurements of Fenoprofen in Supercritical Carbon Dioxide

2020 ◽  
Vol 65 (4) ◽  
pp. 1425-1434 ◽  
Author(s):  
Samyar Zabihi ◽  
Yaghoub Rahnama ◽  
Amir Sharafi ◽  
Fatemeh Borousan ◽  
Ali Zeinolabedini Hezave ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Experimental Solubility ◽  
Supercritical Carbon

scholarly journals Solubility of Acetophenone in Supercritical Carbon Dioxide

2016 ◽  
Vol 10 (1) ◽  
pp. 18-28 ◽  
Author(s):  
Maria Y. Dwi ◽  
Jessica Julian ◽  
Jindrayani N. Putro ◽  
Adi T. Nugraha ◽  
Yi-Hsu Ju ◽  
...  
Keyword(s):  
Experimental Data ◽  
Carbon Dioxide ◽  
Equation Of State ◽  
Supercritical Carbon Dioxide ◽  
Static Method ◽  
Solubility Data ◽  
Experimental Solubility Data ◽  
Experimental Solubility ◽  
Robinson Equation ◽  
Supercritical Carbon

The solubility data of acetophenone in supercritical carbon dioxide (scCO2) were measured using a static method at several temperatures (313.15, 323.15, 333.15, and 343.15K) and pressures ranging from10 MPa to 28 MPa. The density based models (Chrastil and Del valle– Aguilera models) and the Peng-Robinson equation of state (PR-EOS) with quadratic and Stryjek-Vera combining rules were employed to correlate the experimental data. Good correlations between the calculated and experimental solubility data were obtained. The sum of squared errors (SSE) are 0.38 % and 0.37 % for Chrastil and Del Valle – Aguilera models, respectively; and 9.07 % for Peng-Robinson equation of state with quadratic combining rule and 4.00 % for Peng-Robinson equation of state with Stryjek-Vera combining rule.

scholarly journals PALM KERNEL OIL SOLUBITY EXAMINATION AND ITS MODELING IN EXTRACTION PROCESS USING SUPERCRITICAL CARBON DIOXIDE

REAKTOR ◽  
2013 ◽  
Vol 14 (3) ◽  
pp. 242
Author(s):  
Wahyu Bahari Setianto ◽  
Priyo Atmaji ◽  
Didi Dwi Anggoro
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Palm Kernel ◽  
Extraction Process ◽  
Extraction Curve ◽  
Palm Kernel Oil ◽  
Kernel Oil ◽  
Experimental Solubility Data ◽  
Experimental Solubility ◽  
Supercritical Carbon

Application of  supercritical carbon dioxide (SC-CO2) to vegetable oil extraction became an attractive technique due to its high solubility, short extraction time and simple purification. The method is considered as earth friendly technology due to the absence of chemical usage. Solubility of solute-SC-CO2 is an important data for application of the SC-CO2 extraction. In this work, the equilibrium solubility of the palm kernel oil (PKO) in SC-CO2 has been examined using extraction curve analysis. The examinations were performed at temperature and pressure ranges of  323.15 K to 353.15 K and 20.7 to 34.5 MPa respectively. It was obtained that the experimental solubility were from 0.0160 to 0.0503 g oil/g CO2 depend on the extraction condition. The experimental solubility data was well correlated with a solvent density based model with absolute percent deviation of 0.96. PENENTUAN KELARUTAN MINYAK INTI KELAPA SAWIT DAN PEMODELAN EKSTRAKSI DENGAN KARBON DIOKSIDA SUPERKRITIK. Sehubungan dengan kelarutan yang tinggi, waktu ekstraksi yang pendek dan pemurnian hasil yang mudah, aplikasi karbon dioksida superkritis (SC-CO2) pada ekstraksi minyak nabati menjadi sebuah teknik ekstraksi yang menarik. Karena tanpa penggunaan bahan kimia, metode ekstraksi ini dianggap sebagai teknologi yang ramah lingkungan. Kelarutan zat terlarut pada SC-CO2 merupakan data yang penting dalam aplikasi SC-CO2 pada proses ekstraksi.  Pada penelitian ini,  kelarutan kesetimbangan dari minyak biji sawit (PKO) dalam SC-CO2 telah diuji dengan mengunakan analisa kurva proses ekstraksi. Pengujian kelarutan tersebut dilakukan pada rentang suhu 323,15 K sampai 353,15 K dan rentang tekanan 20,7 MPa sampai 34,5 MPa. Hasil analisa menunjukkan bahwa kelarutan kesetimbangan hasil percobaan  PKO pada SC-CO2 adalah 0.0160 g minyak/g CO2 sampai 0,0503 g minyak/g CO2 tergantung pada kondisi ekstraksi. Data kelarutan kesetimbangan hasil percobaan  telah dikorelasaikan dengan baik menggunakan sebuah model kelarutan yang didasarkan pada densiti pelarut. Pemodelan tersebut mempunyai persen deviasi mutlak  0,96.

scholarly journals Experimental solubility measurement of cephalexin in supercritical carbon dioxide

2014 ◽  
Vol 20 (3) ◽  
pp. 387-395 ◽  
Author(s):  
Safar Shojaee ◽  
Hamid Rajaei ◽  
A.Z. Hezave ◽  
Mostafa Lashkarbolooki ◽  
Feridun Esmaeilzadeh
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Solubility Measurement ◽  
Experimental Solubility ◽  
Supercritical Carbon
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