Prognostic effect of different cut-off values (20mm, 30mm and 40mm) for clinical tumor size in FIGO stage IB cervical cancer

Prognostic factors in FIGO stage IB cervical cancer without lymph node metastasis and the role of adjuvant radiotherapy after radical hysterectomy.ObjectivesThe aim of this study was to evaluate the clinical and pathologic prognostic variables for disease free survival, overall survival and the role of adjuvant radiotherapy in FIGO stage IB cervical carcinoma without lymph node metastasis.MethodsA retrospective review was performed of 393 patients with lymph node negative stage IB cervical cancer treated by type 3 hysterectomy and pelvic lymphadenectomy at the Hacettepe University Hospitals between 1980 and 1997.ResultsThe disease free survival and overall survival were 87.6 and 91.0%, respectively. In univariate analysis, tumor size, depth of invasion, vaginal involvement, lympho-vascular space involvement (LVSI) and adjuvant radiotherapy were found significant in disease free survival. Overall survival was affected by tumor size, LVSI, vaginal involvement and adjuvant radiotherapy. Tumor size, LVSI and vaginal involvement were found as independent prognostic factors for overall and disease free survival in multivariate analysis. Disease free survival, recurrence rate and site did not differ between patients underwent radical surgery and radical surgery plus radiotherapy.ConclusionTumor size, LVSI and vaginal involvement were independent prognostic factors in lymph node negative FIGO stage IB cervical cancer. Adjuvant radiotherapy in stage IB cervical cancer patients with negative nodes provides no survival advantage or better local tumoral control.

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Different patterns of tumor size and serum SCC antigen level for prediction of parametrial invasion in pre- and post-menopausal patients with FIGO stage IB cervical cancer

Gynecologic Oncology ◽

10.1016/j.ygyno.2015.01.345 ◽

2015 ◽

Vol 137 ◽

pp. 138-139

Author(s):

T.W. Kong ◽

S.J. Chang ◽

J.H. Son ◽

S.W. Kang ◽

J. Paek ◽

...

Keyword(s):

Cervical Cancer ◽

Tumor Size ◽

Figo Stage ◽

Antigen Level ◽

Stage Ib ◽

Parametrial Invasion ◽

Post Menopausal ◽

Scc Antigen

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Comparison of adjuvant chemotherapy and radiation in patients with intermediate risk factors after radical surgery in FIGO stage IB–IIA cervical cancer

International Journal of Gynecological Cancer ◽

10.1111/j.1525-1438.2007.01136.x ◽

2008 ◽

Vol 18 (5) ◽

pp. 1027-1031 ◽

Cited By ~ 19

Author(s):

K.-B. Lee ◽

J.-M. Lee ◽

K.-D. Ki ◽

S.-K. Lee ◽

C.-Y. Park ◽

...

Keyword(s):

Risk Factors ◽

Cervical Cancer ◽

Adjuvant Chemotherapy ◽

Tumor Size ◽

Resection Margin ◽

Figo Stage ◽

Uterine Cervical Cancer ◽

Intermediate Risk ◽

Stromal Invasion ◽

Stage Ib

The aim of this study was to compare the outcome of chemotherapy or radiation as adjuvant therapy for patients with FIGO stage IB–IIA cervical cancer and surgically confirmed intermediate risk factors. Data were collected from patients with uterine cervical cancer FIGO stage IB–IIA who had adjuvant chemotherapy following radical hysterectomy with pelvic lymph node dissection (RHLND, cases) or adjuvant radiotherapy following RHLND (controls). The study groups consisted of 38 cases and 42 controls. Adjuvant treatment was given to the patients with a combination of intermediate risk factors including deep stromal invasion (>50%), lymphvascular space invasion, large tumor size (3–6 cm), or close vaginal resection margin (<1 cm). Comparison of the cases with the controls revealed no significant differences in variables studied including median age (P= 0.18), stage distribution (P= 0.30), histologic subtype (P= 0.93), pathologic tumor size (P= 0.46), depth of the stromal invasion (P= 0.29), lymphvascular space invasion (P= 0.50), and close vaginal resection margin (P= 0.62). The difference in disease-free survival rates was not significant (P= 0.68). However, the overall survival analysis was incomplete due to the limited number of events available at the end of the study period. The findings of this study suggest that adjuvant chemotherapy in patients with FIGO stage IB–IIA uterine cervical cancer and surgically confirmed intermediate risk factors may be effective.

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