Big data and cloud computing are transforming information technology. These comparable technologies are the result of dramatic developments in computational power, virtualization, network bandwidth, availability, storage capability, and cyber-physical systems. The crossroads of these two areas, involves the use of cloud computing services and infrastructure, to support large-scale data analytics research, providing relevant solutions or future possibilities for supply chain management. This chapter broadens the current posture of cloud computing and big data, as associate with the supply chain solutions. This chapter focuses on areas of significant technology and scientific advancements, which are likely to enhance supply chain systems. This evaluation emphasizes the security challenges and mega-trends affecting cloud computing and big data analytics pertaining to supply chain management.