A catalytic method for chemoselective detritylation of 5′-tritylated nucleosides under mild and heterogeneous conditions using silica sulfuric acid as a recyclable catalyst
Silica sulfuric acid is utilized as a green, highly efficient, heterogeneous and recyclable catalyst for the preparation ofβ-enaminones andβ-enamino esters from amines andβ-dicarbonyl compounds under solvent-free conditions at 80 °C. Using this method, the title compounds are produced in high to excellent yields and in short reaction times.