Liquid storage of boar semen: Current and future perspectives on the use of cationic antimicrobial peptides to replace antibiotics in semen extenders

Cationic antimicrobial peptides (CAMPs) can be considered as new potential therapeutic agents for Tuberculosis treatment with a specific amino acid sequence. New studies can be developed in the future to improve the pharmacological properties of CAMPs and also understand possible resistance mechanisms. This review discusses the principal properties of natural and/or synthetic CAMPs, and how these new peptides have a significant specificity for Mycobacterium tuberculosis. Also, we propose some alternative strategies to enhance the therapeutic activity of these CAMPs that include coadministration with nanoparticles and/or classic drugs.

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Membrane targeting cationic antimicrobial peptides

Journal of Colloid and Interface Science ◽

10.1016/j.jcis.2018.10.103 ◽

2019 ◽

Vol 537 ◽

pp. 163-185 ◽

Cited By ~ 56

Author(s):

Daniela Ciumac ◽

Haoning Gong ◽

Xuzhi Hu ◽

Jian Ren Lu

Keyword(s):

Antimicrobial Peptides ◽

Membrane Targeting ◽

Cationic Antimicrobial Peptides

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Cationic Antimicrobial Peptides in Penaeid Shrimp

Marine Biotechnology ◽

10.1007/s10126-011-9381-8 ◽

2011 ◽

Vol 13 (4) ◽

pp. 639-657 ◽

Cited By ~ 65

Author(s):

Anchalee Tassanakajon ◽

Piti Amparyup ◽

Kunlaya Somboonwiwat ◽

Premruethai Supungul

Keyword(s):

Antimicrobial Peptides ◽

Penaeid Shrimp ◽

Cationic Antimicrobial Peptides

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Generation of novel cationic antimicrobial peptides from natural non-antimicrobial sequences by acid-amide substitution

Annals of Clinical Microbiology and Antimicrobials ◽

10.1186/1476-0711-10-11 ◽

2011 ◽

Vol 10 (1) ◽

pp. 11 ◽

Cited By ~ 9

Author(s):

Satoshi Ueno ◽

Masaomi Minaba ◽

Yuji Nishiuchi ◽

Misako Taichi ◽

Yasushi Tamada ◽

...

Keyword(s):

Antimicrobial Peptides ◽

Acid Amide ◽

Cationic Antimicrobial Peptides

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A lack of synergy between membrane-permeabilizing cationic antimicrobial peptides and conventional antibiotics

Biochimica et Biophysica Acta (BBA) - Biomembranes ◽

10.1016/j.bbamem.2014.09.010 ◽

2015 ◽

Vol 1848 (1) ◽

pp. 8-15 ◽

Cited By ~ 19

Author(s):

Jing He ◽

Charles G. Starr ◽

William C. Wimley

Keyword(s):

Antimicrobial Peptides ◽

Cationic Antimicrobial Peptides ◽

Conventional Antibiotics

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Bordetella pertussis Lipid A Glucosamine Modification Confers Resistance to Cationic Antimicrobial Peptides and Increases Resistance to Outer Membrane Perturbation

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.02590-14 ◽

2014 ◽

Vol 58 (8) ◽

pp. 4931-4934 ◽

Cited By ~ 19

Author(s):

Nita R. Shah ◽

Robert E. W. Hancock ◽

Rachel C. Fernandez

Keyword(s):

Immune System ◽

Antimicrobial Peptides ◽

Outer Membrane ◽

Bordetella Pertussis ◽

Lipid A ◽

Whooping Cough ◽

Human Immune System ◽

Cationic Antimicrobial Peptides ◽

Content Type ◽

Membrane Perturbation

ABSTRACTBordetella pertussis, the causative agent of whooping cough, has many strategies for evading the human immune system. Lipopolysaccharide (LPS) is an important Gram-negative bacterial surface structure that activates the immune system via Toll-like receptor 4 and enables susceptibility to cationic antimicrobial peptides (CAMPs). We show modification of the lipid A region of LPS with glucosamine increased resistance to numerous CAMPs, including LL-37. Furthermore, we demonstrate that this glucosamine modification increased resistance to outer membrane perturbation.

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