Nitrite or sildenafil, but not BAY 41-2272, blunt acute pulmonary embolism-induced increases in circulating matrix metalloproteinase-9 and oxidative stress

2009 ◽  
Vol 124 (3) ◽  
pp. 349-355 ◽  
Author(s):  
Carlos A. Dias-Junior ◽  
Stefany B.A. Cau ◽  
Alisson M. Oliveira ◽  
Michele M. Castro ◽  
Marcelo F. Montenegro ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Pulmonary Embolism ◽  
Matrix Metalloproteinase ◽  
Acute Pulmonary Embolism ◽  
Matrix Metalloproteinase 9 ◽  
Metalloproteinase 9 ◽  
And Oxidative Stress

Protective effects of atorvastatin in rat models of acute pulmonary embolism: Involvement of matrix metalloproteinase-9*

2007 ◽  
Vol 35 (1) ◽  
pp. 239-245 ◽  
Author(s):  
Debora C. Souza-Costa ◽  
Livia Figueiredo-Lopes ◽  
Jose C. Alves-Filho ◽  
Maria C. Semprini ◽  
Raquel F. Gerlach ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Matrix Metalloproteinase ◽  
Acute Pulmonary Embolism ◽  
Matrix Metalloproteinase 9 ◽  
Protective Effects ◽  
Rat Models ◽  
Metalloproteinase 9

Relationship between matrix metalloproteinase-9 and oxidative stress in drug-free male schizophrenia: a case control study

2016 ◽  
Vol 54 (3) ◽  
Author(s):  
Sivasankar Devanarayanan ◽  
Hanumanthappa Nandeesha ◽  
Shivanand Kattimani ◽  
Siddharth Sarkar
Keyword(s):  
Oxidative Stress ◽  
Synaptic Plasticity ◽  
Matrix Metalloproteinase ◽  
Disease Severity ◽  
Positive Association ◽  
Total Antioxidant Status ◽  
Serum Levels ◽  
Matrix Metalloproteinase 9 ◽  
Metalloproteinase 9 ◽  
And Oxidative Stress

AbstractDeregulation of synaptic plasticity and oxidative stress are reported to play a crucial role in the pathogenesis of schizophrenia. Matrix metalloproteinase-9 (MMP-9) is an extracellular protease involved in regulation of synaptic plasticity. Malondialdehyde (MDA) is a marker of lipid peroxidation which is elevated in schizophrenia. Earlier studies have reported polymorphism of MMP-9 and its association with schizophrenia. The present study was designed to assess the serum levels of MMP-9, MDA and total antioxidant status (TAS) and their association in schizophrenia.A total of 40 cases and 40 controls were included in the study. Serum MMP-9, MDA and TAS were estimated in all the subjects. Disease severity was assessed using Positive and Negative Syndrome Scale (PANSS).MMP-9 and MDA were significantly increased and TAS were significantly reduced in schizophrenia cases compared to controls. MMP-9 was positively correlated with MDA (r=0.353, p=0.025) and negatively correlated with TAS (r=−0.461, p=0.003). TAS was significantly correlated with total (r=0.322, p=0.043) and negative symptom scores (r=0.336, p=0.034). Higher MMP-9 levels were associated with previous exposure to antipsychotics (p=0.032).MMP-9 and oxidative stress were increased and correlate well with each other in schizophrenia cases. Though total oxidant status showed positive association with disease severity, MMP-9 and MDA were not associated with the severity of the disease.

L-arginine Attenuates Acute Pulmonary Embolism-Induced Increases in Lung Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9

CHEST Journal ◽  
2005 ◽  
Vol 128 (5) ◽  
pp. 3705-3710 ◽  
Author(s):  
Debora C. Souza-Costa ◽  
Talita Zerbini ◽  
Ana C. Palei ◽  
Raquel F. Gerlach ◽  
Jose E. Tanus-Santos
Keyword(s):  
Pulmonary Embolism ◽  
Matrix Metalloproteinase ◽  
Acute Pulmonary Embolism ◽  
Matrix Metalloproteinase 9 ◽  
Matrix Metalloproteinase 2 ◽  
Lung Matrix ◽  
Metalloproteinase 9

Hemodynamic Benefits of Matrix Metalloproteinase-9 Inhibition by Doxycycline During Experimental Acute Pulmonary Embolism

Angiology ◽  
2005 ◽  
Vol 56 (5) ◽  
pp. 611-617 ◽  
Author(s):  
Ana C.T. Palei ◽  
Rafael A.G. Zaneti ◽  
Geisa M. Fortuna ◽  
Raquel F. Gerlach ◽  
Jose E. Tanus-Santos
Keyword(s):  
Pulmonary Embolism ◽  
Matrix Metalloproteinase ◽  
Acute Pulmonary Embolism ◽  
Matrix Metalloproteinase 9 ◽  
Metalloproteinase 9

A role for matrix metalloproteinase-9 in the hemodynamic changes following acute pulmonary embolism

2007 ◽  
Vol 114 (1) ◽  
pp. 22-27 ◽  
Author(s):  
Geisa M. Fortuna ◽  
Lívia Figueiredo-Lopes ◽  
Carlos A.C. Dias-Junior ◽  
Raquel F. Gerlach ◽  
Jose E. Tanus-Santos
Keyword(s):  
Pulmonary Embolism ◽  
Matrix Metalloproteinase ◽  
Acute Pulmonary Embolism ◽  
Matrix Metalloproteinase 9 ◽  
Hemodynamic Changes ◽  
Metalloproteinase 9

Increases in circulating matrix metalloproteinase-9 levels following fibrinolysis for acute pulmonary embolism

2010 ◽  
Vol 125 (6) ◽  
pp. 549-553 ◽  
Author(s):  
Diána Mühl ◽  
Subhamay Ghosh ◽  
Juliana A. Uzuelli ◽  
János Lantos ◽  
Jose E. Tanus-Santos
Keyword(s):  
Pulmonary Embolism ◽  
Matrix Metalloproteinase ◽  
Acute Pulmonary Embolism ◽  
Matrix Metalloproteinase 9 ◽  
Metalloproteinase 9
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