Structure and function of two-pore-domain K channels: contributions from genetic model organisms

2005 ◽  
Vol 26 (7) ◽  
pp. 361-367 ◽  
Author(s):  
S BUCKINGHAM ◽  
J KIDD ◽  
R LAW ◽  
C FRANKS ◽  
D SATTELLE
Keyword(s):  
Genetic Model ◽  
Structure And Function ◽  
Model Organisms ◽  
K Channels ◽  
And Function ◽  
Pore Domain

scholarly journals Minimal art: Or why small viral K+ channels are good tools for understanding basic structure and function relations

2011 ◽  
Vol 1808 (2) ◽  
pp. 580-588 ◽  
Author(s):  
Gerhard Thiel ◽  
Dirk Baumeister ◽  
Indra Schroeder ◽  
Stefan M. Kast ◽  
James L. Van Etten ◽  
...  
Keyword(s):  
Basic Structure ◽  
Structure And Function ◽  
K Channels ◽  
Minimal Art ◽  
And Function

scholarly journals New structure and function in plant K+ channels: KCO1, an outward rectifier with a steep Ca2+ dependency

1997 ◽  
Vol 16 (22) ◽  
pp. 6896-6896 ◽  
Author(s):  
K. Czempinski ◽  
S. Zimmermann ◽  
T. Ehrhardt ◽  
B. Muller-Rober
Keyword(s):  
Structure And Function ◽  
K Channels ◽  
And Function

scholarly journals Maternal vitamin B12 in mice positively regulates bone, but not muscle mass and strength in post-weaning and mature offspring

2021 ◽  
Author(s):  
Parminder Singh ◽  
Svetalana Telnova ◽  
Bin Zhou ◽  
Abdalla D Mohamed ◽  
Vanessa De Mello ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Mass ◽  
Muscle Mass ◽  
Genetic Model ◽  
Single Injection ◽  
Structure And Function ◽  
Wild Type ◽  
And Function ◽  
Mouse Genetic Model ◽  
Mouse Genetic

Vitamin B12 deficiency has been shown to affect bone mass in rodents and negatively impact bone formation in humans. In this study using mouse models we define the effect of B12 supplementation in the wild-type mother and B12 deficiency in a mouse genetic model (Gif-/- mice) during gestation on the bone and muscle architecture, and mechanical properties in the offspring. Analysis of bones from 4 weeks-old offspring of the wild-type mother following vehicle or B12 supplementation during gestation (From embryonic day 0.5-20.5) showed an increase in bone mass caused by an isolated increase in bone formation in the B12 supplemented group compared to vehicle controls. Analysis of effect of B12 deficiency in the mother in a mouse genetic model (Gif-/- mice) on long bone architecture of the offspring showed a compromised cortical and trabecular bone mass, which was completely prevented by a single injection of B12 in the B12-deficient Gif-/- mothers.Biomechanical analysis of long bones of the offspring born from B12 supplemented wild-type mothers showed an increase in bone strength, and conversely offspring born from B12-deficient Gif-/- mothers revealed a compromised bone strength, which could be rescued by a single injection of B12 in the B12-deficient Gif-/- mother. Muscle structure and function analysis however revealed no significant effect on muscle mass, structure and grip strength of B12 deficiency or supplementation in Gif-/- mice compared to littermate controls. Together, these results demonstrate the beneficial effect of maternally-derived B12 in the regulation of bone structure and function in the offspring.

Correlating structure and function in ATP-sensitive K+ channels

1998 ◽  
Vol 21 (7) ◽  
pp. 288-294 ◽  
Author(s):  
Frances M. Ashcroft ◽  
Fiona M. Gribble
Keyword(s):  
Structure And Function ◽  
K Channels ◽  
And Function

scholarly journals DescribePROT: database of amino acid-level protein structure and function predictions

2020 ◽  
Vol 49 (D1) ◽  
pp. D298-D308 ◽  
Author(s):  
Bi Zhao ◽  
Akila Katuwawala ◽  
Christopher J Oldfield ◽  
A Keith Dunker ◽  
Eshel Faraggi ◽  
...  
Keyword(s):  
Amino Acid ◽  
Protein Function ◽  
Acid Level ◽  
Solvent Accessibility ◽  
Amino Acid Level ◽  
Structure And Function ◽  
Model Organisms ◽  
Comprehensive Collection ◽  
Uniprot Accession ◽  
And Function

Abstract We present DescribePROT, the database of predicted amino acid-level descriptors of structure and function of proteins. DescribePROT delivers a comprehensive collection of 13 complementary descriptors predicted using 10 popular and accurate algorithms for 83 complete proteomes that cover key model organisms. The current version includes 7.8 billion predictions for close to 600 million amino acids in 1.4 million proteins. The descriptors encompass sequence conservation, position specific scoring matrix, secondary structure, solvent accessibility, intrinsic disorder, disordered linkers, signal peptides, MoRFs and interactions with proteins, DNA and RNAs. Users can search DescribePROT by the amino acid sequence and the UniProt accession number and entry name. The pre-computed results are made available instantaneously. The predictions can be accesses via an interactive graphical interface that allows simultaneous analysis of multiple descriptors and can be also downloaded in structured formats at the protein, proteome and whole database scale. The putative annotations included by DescriPROT are useful for a broad range of studies, including: investigations of protein function, applied projects focusing on therapeutics and diseases, and in the development of predictors for other protein sequence descriptors. Future releases will expand the coverage of DescribePROT. DescribePROT can be accessed at http://biomine.cs.vcu.edu/servers/DESCRIBEPROT/.

scholarly journals Structure and function of cardiac ATP-sensitive K+ channels.

1999 ◽  
Vol 19 (2) ◽  
pp. 111-119
Author(s):  
Mitsuhiko Yamada ◽  
Yoshihisa Kurachi
Keyword(s):  
Structure And Function ◽  
K Channels ◽  
And Function
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