scholarly journals Structure and function of δ-atracotoxins: lethal neurotoxins targeting the voltage-gated sodium channel

Toxicon ◽  
2004 ◽  
Vol 43 (5) ◽  
pp. 587-599 ◽  
Author(s):  
Graham M. Nicholson ◽  
Michelle J. Little ◽  
Liesl C. Birinyi-Strachan
Keyword(s):  
Sodium Channel ◽  
Structure And Function ◽  
Voltage Gated Sodium Channel ◽  
Voltage Gated ◽  
And Function

Structure and function of splice variants of the cardiac voltage-gated sodium channel Nav1.5

2010 ◽  
Vol 49 (1) ◽  
pp. 16-24 ◽  
Author(s):  
Annett Schroeter ◽  
Stefan Walzik ◽  
Steve Blechschmidt ◽  
Volker Haufe ◽  
Klaus Benndorf ◽  
...  
Keyword(s):  
Sodium Channel ◽  
Splice Variants ◽  
Structure And Function ◽  
Voltage Gated Sodium Channel ◽  
Voltage Gated ◽  
And Function

Abstract 17384: Cardiac-Specific Overexpression of Human Mutant Desmoplakin in Mice Disrupts Cardiac Voltage-Gated Sodium Channel Expression

Circulation ◽  
2018 ◽  
Vol 138 (Suppl_1) ◽  
Author(s):  
Subat Turdi ◽  
Jeffrey A Towbin
Keyword(s):  
Sodium Channel ◽  
Fatty Infiltration ◽  
Electrical Coupling ◽  
Cx43 Expression ◽  
Voltage Gated Sodium Channel ◽  
Voltage Gated ◽  
Intercalated Discs ◽  
Channel Expression ◽  
Life Threatening ◽  
And Function

Introduction: Arrhythmogenic cardiomyopathy (AC) is characterized by bi-ventricular dilation, fibro-fatty infiltration and life-threatening arrhythmias. Disruptions in cardiac voltage-gated sodium channel (Nav1.5) expression and function are known to cause arrhythmias. We have demonstrated that cardiac-specific overexpression of human mutant desmoplakin (DSP, Tg-R2834H) in mice leads to AC. However, whether mutant DSP expression in the heart affects the Nav1.5 distribution and function are unknown Hypothesis: Here, we tested whether Nav1.5 localization and expression are altered in the R2834H-Tg mouse hearts. Methods: Primary cardiomyocytes and frozen myocardial sections from non-transgenic (NTg), wild-type DSP (Tg-DSP) and Tg-R2834H mice were used for immunofluorescence studies to assess subcellular localization of DSP, desmin, Nav1.5, Cx43, plakoglobin and β-catenin. Western blot and qPCR were used for quantitative analysis. Results: Double staining of cardiomyocytes from NTg mice with DSP and Nav1.5 revealed that Nav1.5 was colocalized with DSP at the intercalated discs (IDs). In contrast, Tg-R2834H cardiomyocytes exhibited marked increase of mutant DSP expression at the IDs concomitant with a reduction in Nav1.5 immunoreactive signals. Tg-R2834H cardiomyocytes also revealed an aberration of DSP and desmin colocalizations at the IDs. There were not obvious differences in Cx43 expression between the genotypes, although the redistribution of Cx43 from the IDs to the sarcolemma was evident in Tg-R2834H cardiomyocytes. qPCR results correlated with reduced Nav1.5 mRNA expression in the Tg-R2834H mouse hearts. Conclusions: Defective DSP protein expression in the heart disrupts Nav1.5 localization and expression, implying an interaction between DSP and Nav1.5 to orchestrate normal mechanical and electrical coupling. Further electrophysiology studies to assess whole-cell Na + currents in these cardiomyocytes will provide insight into DSP and Nav1.5 interaction.

scholarly journals Expression and function of theScn5a-encoded voltage-gated sodium channel NaV1.5 in the rat jejunum

2015 ◽  
Vol 28 (1) ◽  
pp. 64-73 ◽  
Author(s):  
A. Beyder ◽  
S. J. Gibbons ◽  
A. Mazzone ◽  
P. R. Strege ◽  
S. A. Saravanaperumal ◽  
...  
Keyword(s):  
Sodium Channel ◽  
Rat Jejunum ◽  
Voltage Gated Sodium Channel ◽  
Voltage Gated ◽  
And Function

scholarly journals Structure and function of a novel voltage-gated, tetrodotoxin-resistant sodium channel specific to sensory neurons.

1996 ◽  
Vol 271 (22) ◽  
pp. 13292
Author(s):  
Lakshmi Sangameswaran ◽  
Stephen G. Delgado ◽  
Linda M. Fish ◽  
Bruce D. Koch ◽  
Lyn B. Jakeman ◽  
...  
Keyword(s):  
Sodium Channel ◽  
Sensory Neurons ◽  
Structure And Function ◽  
Voltage Gated ◽  
And Function

scholarly journals Voltage-gated sodium channel expression and function in injured and uninjured sensory ganglia neurons

2012 ◽  
Vol 13 (4) ◽  
pp. S41
Author(s):  
B. Moyer ◽  
R. Yin ◽  
D. Liu ◽  
M. Chhoa ◽  
C. Li ◽  
...  
Keyword(s):  
Sodium Channel ◽  
Sensory Ganglia ◽  
Voltage Gated Sodium Channel ◽  
Voltage Gated ◽  
Channel Expression ◽  
And Function

scholarly journals Structure and Function of a Novel Voltage-gated, Tetrodotoxin-resistant Sodium Channel Specific to Sensory Neurons

1996 ◽  
Vol 271 (11) ◽  
pp. 5953-5956 ◽  
Author(s):  
Lakshmi Sangameswaran ◽  
Stephen G. Delgado ◽  
Linda M. Fish ◽  
Bruce D. Koch ◽  
Lyn B. Jakeman ◽  
...  
Keyword(s):  
Sodium Channel ◽  
Sensory Neurons ◽  
Structure And Function ◽  
Voltage Gated ◽  
And Function

The Voltage-Gated Sodium Channel Nav1.2 Contributes to Neurodegeneration in an Animal Model of Multiple Sclerosis

2016 ◽  
Vol 47 (S 01) ◽  
Author(s):  
W. Fazeli ◽  
B. Schattling ◽  
B. Engeland ◽  
M. Friese ◽  
D. Isbrand
Keyword(s):  
Multiple Sclerosis ◽  
Animal Model ◽  
Sodium Channel ◽  
Voltage Gated Sodium Channel ◽  
Voltage Gated
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