scholarly journals Will the clinical development of 4th-generation “double mutant active” ALK TKIs (TPX-0131 and NVL-655) change the future treatment paradigm of ALK+ NSCLC?

2021 ◽  
Vol 14 (11) ◽  
pp. 101191
Author(s):  
Sai-Hong Ignatius Ou ◽  
Misako Nagasaka ◽  
Danielle Brazel ◽  
Yujie Hou ◽  
Viola W. Zhu
Keyword(s):  
Double Mutant ◽  
Clinical Development ◽  
Future Treatment ◽  
The Future ◽  
Treatment Paradigm

The Cochlear Nucleus as a Generator of Tinnitus-Related Signals

2018 ◽  
pp. 188-222
Author(s):  
J.A. Kaltenbach ◽  
D.A. Godfrey
Keyword(s):  
Cochlear Nucleus ◽  
Neural Circuitry ◽  
Clinical Implications ◽  
Future Treatment ◽  
Cortical Level ◽  
The Future ◽  
Research Findings ◽  
The Brain

Tinnitus most commonly begins with alterations of input from the ear resulting from cochlear trauma or overstimulation of the ear. Because the cochlear nucleus is the first processing center in the brain receiving cochlear input, it is the first brainstem station to adjust to this modified input from the cochlea. Research published over the last 30 years demonstrates changes in neural circuitry and activity in the cochlear nucleus that are associated with and may be the origin of the signals that give rise to tinnitus percepts at the cortical level. This chapter summarizes what is known about these disturbances and their relationships to tinnitus. It also summarizes the mechanisms that trigger tinnitus-related disturbances and the anatomical, chemical, neurophysiological, and biophysical defects that underlie them. It concludes by highlighting some major controversies that research findings have generated and discussing the clinical implications the findings have for the future treatment of tinnitus.

Therapeutic approaches for the future treatment of Fragile X

2015 ◽  
Vol 4 ◽  
pp. 6-21 ◽  
Author(s):  
Ana Sastre ◽  
Nuria E Campillo ◽  
Carmen Gil ◽  
Ana Martinez
Keyword(s):  
Fragile X ◽  
Therapeutic Approaches ◽  
Future Treatment ◽  
The Future

Brennilis Decommissioning: The Case of the Treatment Station and the Discharge Channel Remediation

2013 ◽  
Author(s):  
Catherine Ollivier Dehaye ◽  
Gilles Pellenz
Keyword(s):  
Heavy Water ◽  
Discharge Channel ◽  
Management Plan ◽  
Water Reactor ◽  
Future Treatment ◽  
The Future ◽  
Heavy Water Reactor ◽  
Industrial Prototype

The site of the Monts d’Arrée located in Brennilis in the area of Brittany in France is a former 70 MWe heavy water reactor, that was jointly operated by CEA and EDF from 1967 until 1985. It was an industrial prototype. EDF is now in charge of its decommissioning. This paper presents the management plan and the remediation objectives that were approved by the French Nuclear Authority for the channel remediation and the first studies carried out for the future Treatment Station remediation.

Paving the way for new agents; is standard chemotherapy part of the treatment paradigm for chronic lymphocytic leukemia in the future?

2016 ◽  
Vol 9 (7) ◽  
pp. 679-693 ◽  
Author(s):  
Anna Maria Frustaci ◽  
Marco Montillo ◽  
Paola Picardi ◽  
Maddalena Mazzucchelli ◽  
Roberto Cairoli ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
Standard Chemotherapy ◽  
New Agents ◽  
The Future ◽  
Treatment Paradigm ◽  
The Way
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