Fluorescence visualization of deep-buried hollow organs

High-definition fluorescence imaging of deep-buried organs is still challenging. Here, we develop bright fluorophores emitting to 1700 nm by enhancing electron donating ability and reducing donor-acceptor distance. In parallel, the heavy water functions as the solvent of the delicately designed fluorophores, effectively reducing the fluorescent signal loss caused by the absorption by water. The near-infrared-II (NIR-II, 900-1880 nm) emission is eventually recovered and extended beyond 1400 nm. Compared with the spectral range beyond 1500 nm, the one beyond 1400 nm gives a more accurate fluorescence visualization of the hollow organs, owing to the absorption-induced scattering suppression. In addition, the intraluminal lesions containing much water are simultaneously negatively stained, leading to a stark contrast for precise diagnosis. Eventually, the intraluminally perfused fluorescent probes are excreted from mice and thus no obvious side effects emerge. This general method can provide new avenues for future biomedical imaging of deep and highly scattering tissues.

Synthesis and characterization of some 1, 5-benzodiazepine derivatives from Chalcones and their use as scavengers for some heavy metals in Environmental Systems.

Chalcones (A1-A4) compounds were prepared by reacting an aldehyde (Cinnamaldehyde or terphthaldehyde) with a ketone (4-aminoacetophenone or acetylacetone) in the presence of 30% NaOH as a catalyst and ethanol as a solvent. Derivatives of 1,5-benzodiazepine (A5-A12) were prepared by reacting these prepared chalcones with orthophenylene diamine or 4-methylorthophenylene diamine in a basic medium of sodium hydroxide 10% using the microwave method. Some prepared compounds were used as scavengers of some heavy metals (iron and lead) from heavy water in ecosystems, as the results indicated the ability of these compounds to reduce or withdraw these elements from heavy water. The stability of these compounds was also tested against laser rays, as they showed resistance and stability towards laser rays.