Cord blood platelet gel for the treatment of inherited epidermolysis bullosa

2018 ◽  
Vol 57 (3) ◽  
pp. 370-373 ◽  
Author(s):  
Alessandra Gelmetti ◽  
Noemi Greppi ◽  
Sophie Guez ◽  
Francesca Grassi ◽  
Paolo Rebulla ◽  
...  
Keyword(s):  
Cord Blood ◽  
Epidermolysis Bullosa ◽  
Blood Platelet ◽  
Platelet Gel ◽  
Inherited Epidermolysis Bullosa

scholarly journals Cord blood platelet gel treatment of dystrophic recessive epidermolysis bullosa

2015 ◽  
Vol 2015 (jan08 1) ◽  
pp. bcr2014207364-bcr2014207364 ◽  
Author(s):  
G. Tadini ◽  
L. Pezzani ◽  
S. Ghirardello ◽  
P. Rebulla ◽  
S. Esposito ◽  
...  
Keyword(s):  
Cord Blood ◽  
Epidermolysis Bullosa ◽  
Blood Platelet ◽  
Platelet Gel ◽  
Gel Treatment

Efficacy of allogeneic cord blood platelet gel on wounds of dystrophic epidermolysis bullosa patients after pseudosyndactyly surgery

2020 ◽  
Author(s):  
Elham Torkamaniha ◽  
Mohammad Amir Amirkhani ◽  
Mostafa Dahmardehei ◽  
Paolo Rebulla ◽  
Andrea Piccin ◽  
...  
Keyword(s):  
Cord Blood ◽  
Epidermolysis Bullosa ◽  
Blood Platelet ◽  
Platelet Gel ◽  
Dystrophic Epidermolysis Bullosa

Use of cord blood platelet gel to enhance healing of deep surgical site dehiscences after peripheral bypass

2020 ◽  
Author(s):  
Pietro Volpe ◽  
Giulia Pucci ◽  
Giuseppe Stilo ◽  
Antonino Alberti ◽  
Giovanni Foti ◽  
...  
Keyword(s):  
Cord Blood ◽  
Outpatient Surgery ◽  
Blood Platelet ◽  
Major Amputation ◽  
Vacuum Assisted Closure ◽  
Platelet Gel ◽  
Early Graft ◽  
Vacuum Assisted Closure Therapy ◽  
Early Graft Failure ◽  
Subsequent Risk

Surgical site dehiscence after lower limb revascularization through bypass represents a serious postoperative complication, especially in diabetic and obese patients, with subsequent risk of early graft failure, infection, sepsis, hemorrhage, major amputation and sometimes death. To prevent bypass exposure and subsequent complications, physicians recur to reoperation, antibiotic therapy, advanced dressing and vacuum-assisted closure therapy. To improve the process of wound healing, cord blood platelet gel can be used to fill deep and large wounds. Growth factors released from platelets in the cord blood platelet gel stimulate the process of healing and allow patients to be followed up in Outpatient Surgery, thus reducing hospital stay and costs, while providing excellent results.

Evaluation of cord blood platelet gel production utilizing low volume cord blood units: the experience of hellenic cord blood bank

Cytotherapy ◽  
2021 ◽  
Vol 23 (5) ◽  
pp. S161
Author(s):  
P. Mallis ◽  
Z. Dimou ◽  
E. Panagouli ◽  
J. Zoidakis ◽  
P. Sarri ◽  
...  
Keyword(s):  
Cord Blood ◽  
Blood Platelet ◽  
Blood Bank ◽  
Platelet Gel ◽  
Cord Blood Bank ◽  
Low Volume

First endocavitary treatment with cord blood platelet gel for perianal fistula

2020 ◽  
Vol 15 (1) ◽  
pp. 1171-1176 ◽  
Author(s):  
Giovanni Bisceglia ◽  
Michele Santodirocco ◽  
Augusta Faienza ◽  
Nicola Mastrodonato ◽  
Filomena Urbano ◽  
...  
Keyword(s):  
Growth Factors ◽  
Cord Blood ◽  
Tissue Repair ◽  
Perianal Fistula ◽  
Blood Platelet ◽  
Platelet Concentrate ◽  
Liquid Form ◽  
Platelet Gel ◽  
Deep Cavities

Cord blood platelet gel is prepared by activation of coagulation in a platelet concentrate obtained from cord blood. During the process of clot formation, platelet alpha-granules release growth factors that promote tissue repair. However, in the form of gel, it is not possible to inject it into small, narrow and deep cavities. Therefore, we analyzed gelification kinetics and developed an application technique of platelet gel in liquid form. This semi-activated form provides for the activation of the coagulation process but not the gelification of the platelet concentrate. In this way, it can be easily inoculated in an endocavitary space, and then complete in vivo the gelification process. We report the successful use of this procedure to heal a recurrent perianal fistula.

Impressive tissue regeneration of severe oral mucositis post stem cell transplantation using cord blood platelet gel

Transfusion ◽  
2017 ◽  
Vol 57 (9) ◽  
pp. 2220-2224 ◽  
Author(s):  
Andrea Piccin ◽  
Paolo Rebulla ◽  
Simonetta Pupella ◽  
Mario Tagnin ◽  
Giuseppe Marano ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cord Blood ◽  
Cell Transplantation ◽  
Tissue Regeneration ◽  
Oral Mucositis ◽  
Blood Platelet ◽  
Platelet Gel ◽  
Severe Oral Mucositis

The role of the cord blood platelet gel in the management of a diabetic foot with tendon exposure

2021 ◽  
Author(s):  
Mafalda Massara ◽  
Giulia Pucci ◽  
Giuseppe Stilo ◽  
Antonino Alberti ◽  
Rosangela Surace ◽  
...  
Keyword(s):  
Antibiotic Therapy ◽  
Cord Blood ◽  
Diabetic Foot ◽  
Healing Process ◽  
Limb Ischemia ◽  
Blood Platelet ◽  
Arterial Disease ◽  
Diabetic Patients ◽  
Platelet Gel ◽  
Vital Functions

Diabetic foot infection is frequent in diabetic patients and is due to neuropathy, trauma or peripheral arterial disease. The presence of an abscess requires urgent drainage and specific antibiotic therapy. Patients with critical limb ischemia need revascularization and, subsequently the intervention of a plastic surgeon is often required in cases of exposure of tendons and ligaments. During the COVID-19 pandemic, a patient was refered to our department with an abscess on the dorsum of the left foot. After urgent drainage with tendon exposure, he started specific antibiotic therapy and underwent tibial vessels angioplasty. After infection healing cord blood platelet gel was applied, accelerating the healing process, with injection of its liquid part into the exposed tendons, thus retaining the vital functions of the tendons.

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