Withdrawal of Steroids: A Randomized Prospective Study of Prednisone and Tacrolimus Versus Mycophenolate Mofetil and Tacrolimus in Liver Transplant Recipients With Autoimmune Hepatitis

2005 ◽  
Vol 37 (4) ◽  
pp. 1695-1696 ◽  
Author(s):  
G. Junge ◽  
R. Neuhaus ◽  
L. Schewior ◽  
J. Klupp ◽  
O. Guckelberger ◽  
...  
Keyword(s):  
Mycophenolate Mofetil ◽  
Prospective Study ◽  
Liver Transplant ◽  
Autoimmune Hepatitis ◽  
Transplant Recipients ◽  
Liver Transplant Recipients

scholarly journals Interest in Immunosuppression Withdrawal among Liver Transplant and Autoimmune Hepatitis Patients

2021 ◽  
Vol 12 (2) ◽  
pp. 147-154
Author(s):  
Eden Sharabi ◽  
Allison Carroll ◽  
Peter Cummings ◽  
Josh Levitsky
Keyword(s):  
Decision Making ◽  
Liver Transplant ◽  
Autoimmune Hepatitis ◽  
Immunological Tolerance ◽  
Side Effect Profile ◽  
Transplant Recipients ◽  
Single Center ◽  
Patient Reported ◽  
Liver Transplant Recipients ◽  
Mean Time

Immunosuppression withdrawal (ISW) is considered in liver transplant recipients (LTRs) and autoimmune hepatitis patients (AIHPs). Immunosuppressive therapy (IST) can be burdensome both financially and due to its side effect profile, making ISW an important intervention to consider. Data on patient interest in ISW would be helpful to providers in ISW decision-making. We conducted independent single-center surveys of LTR and AIHP attitudes on IST and withdrawal interest. Of 325 LTRs screened, 120 completed the survey (50% female, mean age 58 ± 14 years, mean time since transplant 8 ± 10.5 years and 79.5% Caucasian). Of 100 AIHPs screened, 45 completed the survey (77.8% female, mean age 54 ± 2 and 82.2% Caucasian). A higher percentage of AIHPs expressed concern with their IST and were interested in ISW compared with LTRs. However, over a third of LTRs were interested in ISW, particularly those with knowledge of this potential intervention. LTRs who discussed ISW with a physician were more likely to desire withdrawal (p = 0.02; OR = 2.781 (95% CI = 1.125, 6.872)). As patient interest in ISW is of growing interest, investigators should continue to assess patient-reported desires and outcomes and pursue strategies to achieve immunological tolerance.

INCIDENCE AND RECURRENCE OF AUTOIMMUNE HEPATITIS IN LIVER TRANSPLANT RECIPIENTS

1999 ◽  
Vol 67 (9) ◽  
pp. S578
Author(s):  
E P Molmenti ◽  
G J Netto ◽  
J S Crippin ◽  
A C Conkey ◽  
T C Hoover ◽  
...  
Keyword(s):  
Liver Transplant ◽  
Autoimmune Hepatitis ◽  
Transplant Recipients ◽  
Liver Transplant Recipients

scholarly journals Prospective study of liver transplant recipients with HCV infection: Evidence for a causal relationship between HCV and insulin resistance

2008 ◽  
Vol 14 (2) ◽  
pp. 193-201 ◽  
Author(s):  
Aymin Delgado-Borrego ◽  
Yun-Sheen Liu ◽  
Sergio H. Jordan ◽  
Saurabh Agrawal ◽  
Hui Zhang ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Prospective Study ◽  
Liver Transplant ◽  
Causal Relationship ◽  
Hcv Infection ◽  
Transplant Recipients ◽  
Liver Transplant Recipients
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