Posttransplant Diabetes Mellitus: Analysis of Risk Factors, Effects on Biochemical Parameters and Graft Function 5 Years after Renal Transplantation

2010 ◽  
Vol 42 (10) ◽  
pp. 4069-4071 ◽  
Author(s):  
D. Madhav ◽  
R. Ram ◽  
K.V. Dakshinamurty
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Renal Transplantation ◽  
Biochemical Parameters ◽  
Graft Function

scholarly journals Explained and Unexplained Ischemic Heart Disease Risk after Renal Transplantation

2000 ◽  
Vol 11 (9) ◽  
pp. 1735-1743 ◽  
Author(s):  
BERTRAM L. KASISKE ◽  
HARINI A. CHAKKERA ◽  
JOSEPH ROEL
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Renal Transplantation ◽  
Relative Risk ◽  
Renal Transplant ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Calcium Channel Antagonists ◽  
Relative Risks ◽  
Cholesterol Levels

Abstract. Whether the high incidence of ischemic heart disease (IHD) among renal transplant patients can be attributed to the same risk factors that have been identified in the general population is unclear. The risk for major IHD events occurring >1 yr after transplantation among 1124 transplant recipients was estimated by using the risk calculated from the Framingham Heart Study (FHS). The FHS risk predicted IHD (relative risk, 1.28; 95% confidence interval, 1.20 to 1.40; P < 0.001); however, the FHS risk tended to underestimate the risk of IHD for renal transplant recipients. This was largely attributable to increased risks associated with diabetes mellitus and, to a lesser extent, age and cigarette smoking for renal transplant recipients. For men, the relative risks for diabetes mellitus were 2.78 (1.73 to 4.49) and 1.53 for the transplant recipient and FHS populations, respectively; the relative risks for age (in years) were 1.06 (1.04 to 1.08) and 1.05, respectively, and those for smoking were 1.95 (1.20 to 3.19) and 1.69, respectively. For women, the relative risks for diabetes mellitus were 5.40 (2.73 to 10.66) and 1.82, respectively. There was a tendency for the risk associated with cholesterol levels to be higher for transplant recipients, compared with the FHS population, but the risks associated with high-density lipoprotein cholesterol levels and BP appeared to be comparable. Independent of these and other risk factors, the adjusted risk of IHD for the transplant recipient population has decreased. Compared with the era before 1986, transplantation between 1986 and 1992 was associated with a lower relative risk of 0.60 (0.39 to 0.92); transplantation after 1992 was associated with an even lower relative risk of 0.27 (0.11 to 0.63) for IHD. Of concern was the fact that dihydropyridine calcium channel antagonists were associated with an increased risk for IHD (relative risk, 2.26; 95% confidence interval, 1.24 to 4.12; P = 0.008), and this association was independent of other antihypertensive agents and risk factors. Therefore, although the FHS risk predicts IHD after renal transplantation, it tends to underestimate the risks, especially the risk associated with diabetes mellitus. The unexpected finding that dihydropyridine calcium channel antagonists were associated with an increased IHD risk merits further evaluation.

ANALYSIS OF DONOR AND RECIPIENT RISK FACTORS FOR DELAYED GRAFT FUNCTION IN RENAL TRANSPLANTATION

1999 ◽  
Vol 67 (9) ◽  
pp. S561
Author(s):  
Christopher P Johnson ◽  
Yong-Ran Zhu ◽  
Rebecca Zurawski ◽  
Elizabeth Bieneman ◽  
Sundaram Hariharan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Renal Transplantation ◽  
Graft Function ◽  
Delayed Graft Function

DONOR RISK FACTORS FOR DELAYED GRAFT FUNCTION (DGF) IN CADAVERIC RENAL TRANSPLANTATION (RTX)

2008 ◽  
Vol 86 (Supplement) ◽  
pp. 378-379
Author(s):  
A Amoroso ◽  
R Giraudi ◽  
M Meucci ◽  
F Fop ◽  
P Magistroni ◽  
...  
Keyword(s):  
Risk Factors ◽  
Renal Transplantation ◽  
Graft Function ◽  
Delayed Graft Function ◽  
Cadaveric Renal Transplantation

scholarly journals Risk Factors for Delayed Renal Graft Function and Their Impact on Renal Transplantation Outcome

2007 ◽  
Vol 39 (8) ◽  
pp. 2473-2475 ◽  
Author(s):  
A. Figueiredo ◽  
P. Moreira ◽  
B. Parada ◽  
P. Nunes ◽  
F. Macário ◽  
...  
Keyword(s):  
Risk Factors ◽  
Renal Transplantation ◽  
Graft Function ◽  
Renal Graft

scholarly journals INFECTIONS DURING FIRST YEAR OF RENAL TRANSPLANTATION: ETIOLOGY, RISK FACTORS AND OUTCOME

2020 ◽  
pp. 1-3
Author(s):  
Amit Katyal ◽  
M.M. Bahadur
Keyword(s):  
Diabetes Mellitus ◽  
Renal Transplantation ◽  
Renal Transplant ◽  
Graft Function ◽  
Western World ◽  
First Year ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Major Infection ◽  
One Year

Background: Renal transplantation is the best treatment in managing end stage renal disease patients.However infections in these patients remain the leading cause of morbidity and mortality[1].Various factors like age, co-morbid infections like Hepatitis C infection and presence of Diabetes Mellitus,play a role in development of these infections.In developing country like ours, the spectrum of infection is likely to be different from the western world[2]. There is paucity of data on this aspect.There exists a conflict in literature regarding the predisposition to these infections and their impact on graft outcome. Aims & Objectives : This study proposes to analyse the predisposing factors,spectrum of infections in renal transplant recipients and their impact on graft function. Materials & Methods : Hundred renal transplant patients who received transplant between 01 Jan 2015 to Dec 2015 were prospectively followed for a period of one year for development of a major infection. All patients underwent thorough evaluation with complete blood count, urine and blood cultures, Radiological investigations and invasive investigations were done on case to case basis to achieve an etiological diagnosis. Special investigations were done when clinically indicated and infections were diagnosed based on established criteria. Those patients who had evidence of graft dysfunction were subjected to kidney biopsy.Descriptive analysis was done for all variables statistical analysis was done using paired/unpaired T test.A p value of < o.o5 was considered significant. Results: 68 patients (68%) had 138 episodes of infection (i.e. 2.02/patient)[3]. There were 42%episodes of bacterial infections,29% of viral infections,8.7% of fungal,7.1% tubercular and 14.4% had miscellaneous infection.There was no significant correlation between development of infection and variables like Diabetes Mellitus, age and HCV infection. There was significant increase in creatinine value at the end of one year,in the patients of infection(p value0.003),which on comparison with the non infected group was not significant(p >0.05). Conclusion: Nearly 68% of transplant recipients had an episode of major infection in the first year of transplantation.The majority of infection were bacterial(42%); and the dominant amongst them, was UTI. Graft survival was not inferior in these patients,at the end of one year.

scholarly journals Risk factors for delayed graft function in deceased donor kidney transplantation; a potential preventive role for intraoperative thymoglobulin

2019 ◽  
Vol 8 (2) ◽  
pp. 157-163
Author(s):  
Neda Naderi ◽  
Azam Alamdari ◽  
Mahboob Lessan-Pezeshki ◽  
Simin Dashti-Khavidaki ◽  
Mehran Heydari-Seradj ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Kidney Transplantation ◽  
Odds Ratio ◽  
Graft Function ◽  
Deceased Donor ◽  
Donor Kidney ◽  
Deceased Donor Kidney ◽  
Donor Kidney Transplantation ◽  
Deceased Donor Kidney Transplantation

Introduction: Delayed graft function (DGF) is associated with significant adverse outcomes in deceased donor kidney transplantation (KT) including lower graft survival. However, risk factors and potential preventive strategies like intraoperative rabbit antithymocyte globulin (rATG; thymoglobulin) have not yet been fully evaluated. Objectives: The aim of this study was to investigate DGF risk factors and determine the association of intraoperative rATG with the risk of DGF in deceased donor kidney recipients. Patients and Methods: We retrospectively examined medical records of 163 first time deceased donor kidney transplant recipients at two major kidney transplant centers from 2014 to 2016. All the donors were standard heart-beating, brain death donors. Risk factors for DGF in recipients were evaluated using multivariate logistic regression analysis. Results: The mean recipients’ age was 43±13 years and the majority of participants were male (64%). The overall rate of DGF was 27%. Intraoperative rATG was significantly associated with a lower rate of DGF (adjusted odds ratio [AOR], 0.33, 95% CI, 0.11-0.95). Intraoperative transfusion (AOR, 3.7, 95% CI, 1.4-9.9) and diabetes mellitus (AOR, 3.7, 95% CI, 1.5-8.9) were significantly associated with higher risk of DGF. Conclusion: This study showed that intraoperative blood transfusion and diabetes mellitus were associated with increased risk of DGF. Meanwhile, administration of intraoperative rATG was associated with reduced odds ratio of DGF. Future studies are needed to evaluate the potential role of rATG in DGF-related renal outcomes.

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