Arterial Stiffness in Renal Transplant Recipients: 5-Year Follow-up

2021 ◽  
Author(s):  
Jan Alatič ◽  
Jelka Lindič ◽  
Uroš Godnov ◽  
Damjan Kovač
Keyword(s):  
Renal Transplant ◽  
Arterial Stiffness ◽  
Renal Transplant Recipients ◽  
Transplant Recipients

scholarly journals SP798RELATIONS AMONG HYPERURICEMIA,INFLAMMATION, OXIDATIVE STRESS AND ARTERIAL STIFFNESS IN RENAL TRANSPLANT RECIPIENTS

2015 ◽  
Vol 30 (suppl_3) ◽  
pp. iii641-iii642
Author(s):  
Bahar Gurlek Demirci ◽  
Mehtap Erkmen Uyar ◽  
Zeynep Bal ◽  
Emre Tutal ◽  
Fatma NurhanOzdemir Acar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Renal Transplant ◽  
Arterial Stiffness ◽  
Renal Transplant Recipients ◽  
Transplant Recipients

scholarly journals Serum Paraoxonase 1 Activity Predicts Arterial Stiffness in Renal Transplant Recipients

2011 ◽  
Vol 18 (10) ◽  
pp. 901-905 ◽  
Author(s):  
Ozkan Gungor ◽  
Fatih Kircelli ◽  
Meltem Sezis Demirci ◽  
Pinar Tuncel ◽  
Ali Riza Sisman ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Arterial Stiffness ◽  
Paraoxonase 1 ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Serum Paraoxonase

scholarly journals High Plasma Branched-Chain Amino Acids Are Associated with Higher Risk of Post-Transplant Diabetes Mellitus in Renal Transplant Recipients

2020 ◽  
Vol 9 (2) ◽  
pp. 511 ◽  
Author(s):  
Maryse C. J. Osté ◽  
Jose L. Flores-Guerrero ◽  
Eke G. Gruppen ◽  
Lyanne M. Kieneker ◽  
Margery A. Connelly ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Amino Acids ◽  
Renal Transplant ◽  
Branched Chain Amino Acids ◽  
Resonance Spectroscopy ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Post Transplant ◽  
Branched Chain

Post-transplant diabetes mellitus (PTDM) is a serious complication in renal transplant recipients. Branched-chain amino acids (BCAAs) are involved in the pathogenesis of insulin resistance. We determined the association of plasma BCAAs with PTDM and included adult renal transplant recipients (≥18 y) with a functioning graft for ≥1 year in this cross-sectional cohort study with prospective follow-up. Plasma BCAAs were measured in 518 subjects using nuclear magnetic resonance spectroscopy. We excluded subjects with a history of diabetes, leaving 368 non-diabetic renal transplant recipients eligible for analyses. Cox proportional hazards analyses were used to assess the association of BCAAs with the development of PTDM. Mean age was 51.1 ± 13.6 y (53.6% men) and plasma BCAA was 377.6 ± 82.5 µM. During median follow-up of 5.3 (IQR, 4.2–6.0) y, 38 (9.8%) patients developed PTDM. BCAAs were associated with a higher risk of developing PTDM (HR: 1.43, 95% CI 1.08–1.89) per SD change (p = 0.01), independent of age and sex. Adjustment for other potential confounders did not significantly change this association, although adjustment for HbA1c eliminated it. The association was mediated to a considerable extent (53%) by HbA1c. The association was also modified by HbA1c; BCAAs were only associated with renal transplant recipients without prediabetes (HbA1c < 5.7%). In conclusion, high concentrations of plasma BCAAs are associated with developing PTDM in renal transplant recipients. Alterations in BCAAs may represent an early predictive biomarker for PTDM.

scholarly journals Malignant and Noninvasive Skin Tumours in Renal Transplant Recipients

2014 ◽  
Vol 2014 ◽  
pp. 1-6
Author(s):  
Christopher D. Roche ◽  
Joelle S. Dobson ◽  
Sion K. Williams ◽  
Mara Quante ◽  
Joyce Popoola ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Skin Tumours ◽  
Skin Malignancy ◽  
Increased Risk ◽  
Malignant Skin ◽  
Risk Of Malignancy

Background.Transplant recipients require immunosuppression to prevent graft rejection. This conveys an increased risk of malignancy, particularly skin tumours. There is a need for up-to-date data for the South of England.Method.Pathology records were reviewed for 709 kidney transplant recipients on immunosuppression at our hospital from 1995 to 2008. Skin tumours were recorded/analysed.Results.Mean age at transplant was 46 years. Mean length of follow-up was 7.2 years and total follow-up was 4926 person-years. 53 (7.5%) patients (39/458 (8.5%) males and 14/251 (5.6%) females) developed ≥1 skin malignancy. Cumulative incidences of 4.0%, 7.5%, and 12.2% were observed for those with <5, <10, and ≥10 years follow-up, respectively. The rate was 45 tumours per 1000 person-years at risk. Additionally, 21 patients (3.0%) only had noninvasive tumours. 221 malignant skin tumours were found: 50.2% were SCCs, 47.1% BCCs, and 2.7% malignant melanomas. Mean years to first tumour were 5.8. Mean number of tumours per patient was 4, with mean interval of 12 months.Conclusions.Despite changes in transplantation practice during the time since the last data were published in this region, these findings are similar to previous studies. This adds to the evidence allowing clinicians to inform patients in this region of their risk.

Long-term follow-up of ABO-incompatible renal transplant recipients

1999 ◽  
Vol 31 (1-2) ◽  
pp. 256-257 ◽  
Author(s):  
H Karakayali ◽  
G Moray ◽  
A Demirağ ◽  
M Turan ◽  
N Bilgin ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Long Term Follow Up

SAFETY AND TOLERABILITY OF CYCLOSPORINE AND CYCLOSPORINE MICROEMULSION DURING 18 MONTHS OF FOLLOW-UP IN STABLE RENAL TRANSPLANT RECIPIENTS

1998 ◽  
Vol 65 (4) ◽  
pp. 505-510 ◽  
Author(s):  
Edward Cole ◽  
Paul Keown ◽  
David Landsberg ◽  
Phillip Halloran ◽  
Ahmed Shoker ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Cyclosporine Microemulsion
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