Diagnostic utility of NT-proBNP and ANP in a canine model of chronic embolic pulmonary hypertension

2012 ◽  
Vol 194 (2) ◽  
pp. 215-221 ◽  
Author(s):  
Yasutomo Hori ◽  
Tsuyoshi Uchide ◽  
Ryuta Saitoh ◽  
Daisuke Thoei ◽  
Makiko Uchida ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Canine Model ◽  
Diagnostic Utility

Efficacy of vasodilator therapy in canine model of acute pulmonary hypertension

1988 ◽  
Vol 255 (5) ◽  
pp. H1232-H1239 ◽  
Author(s):  
H. J. Priebe
Keyword(s):  
Pulmonary Hypertension ◽  
Gas Exchange ◽  
Pulmonary Artery ◽  
Prostaglandin E1 ◽  
Canine Model ◽  
Lung Compliance ◽  
Myocardial Segment ◽  
Vasodilator Therapy ◽  
Artery Flow ◽  
Subsequent Administration

This study was performed to determine 1) the effects of acute pulmonary embolization (induced by injection of autologous muscle) on right ventricular (RV) performance, coronary hemodynamics, and gas exchange; and 2) the efficacy of subsequent administration of nitroglycerin, prostaglandin E1, and hydralazine with regard to improvement in RV function and gas exchange in eight open-chest dogs. After embolization, pulmonary artery (PA) pressure and vascular resistance (PVR) increased three- to fivefold without changes in RV end-diastolic dimensions (ultrasonic dimension technique) or pressure. However, systolic dimensions increased, and stroke volume (SV) fell. Gas exchange, lung compliance, and pH worsened. Subsequent administration of nitroglycerin (5 micrograms.kg-1.min-1) and prostaglandin E1 (0.2 micrograms.kg-1.min-1) caused further decreases in SV and pH. In contrast, hydralazine (mean 0.15 mg/kg) improved myocardial segment shortening, SV, PVR, pulmonary artery flow, and gas exchange. Coronary blood flow increased by 110%. Thus in this canine model of combined pulmonary hypertension and respiratory insufficiency, nitroglycerin and prostaglandin E1 exerted no beneficial cardiopulmonary effects. In contrast, hydralazine improved regional and global RV performance and gas exchange.

Intraluminal Pulsed Doppler Evaluation of the Pulmonary Artery Velocity Time Curve in a Canine Model of Acute Pulmonary Hypertension

CHEST Journal ◽  
1991 ◽  
Vol 100 (2) ◽  
pp. 474-479 ◽  
Author(s):  
G. William Henry ◽  
Hiroshi Katayama ◽  
Manuel E. Lores ◽  
Carol L. Lucas ◽  
Jose I. Ferreiro
Keyword(s):  
Pulmonary Hypertension ◽  
Pulmonary Artery ◽  
Canine Model ◽  
Pulsed Doppler ◽  
Time Curve ◽  
Acute Pulmonary Hypertension ◽  
Doppler Evaluation

scholarly journals Diagnostic Utility of the Physical Examination for Moderate and Severe Pulmonary Hypertension

CHEST Journal ◽  
2016 ◽  
Vol 150 (4) ◽  
pp. 1173A
Author(s):  
Daniel Vis ◽  
Kevin Solverson ◽  
Doug Helmersen ◽  
Jason Weatherald ◽  
Mitesh Thakrar ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Physical Examination ◽  
Diagnostic Utility ◽  
Severe Pulmonary Hypertension

The effect of sildenafil on pulmonary haemodynamics in a canine model of chronic embolic pulmonary hypertension

2020 ◽  
Vol 133 ◽  
pp. 106-110
Author(s):  
Ryota Akabane ◽  
Atsushi Sakatani ◽  
Mizuki Ogawa ◽  
Masayoshi Nagakawa ◽  
Hirosumi Miyakawa ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Canine Model ◽  
Pulmonary Haemodynamics

Effect of the phosphodiesterase type 5 inhibitor tadalafil on pulmonary hemodynamics in a canine model of pulmonary hypertension

2014 ◽  
Vol 202 (2) ◽  
pp. 334-339 ◽  
Author(s):  
Yasutomo Hori ◽  
Chigusa Kondo ◽  
Maho Matsui ◽  
Maki Yamagishi ◽  
Shozo Okano ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Canine Model ◽  
Pulmonary Hemodynamics ◽  
Phosphodiesterase Type 5 Inhibitor ◽  
Phosphodiesterase Type
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