2-D Left Ventricular Flow Estimation by Combining Speckle Tracking With Navier–Stokes-Based Regularization: An In Silico, In Vitro and In Vivo Study

2015 ◽  
Vol 41 (1) ◽  
pp. 99-113 ◽  
Author(s):  
Hang Gao ◽  
Nathalie Bijnens ◽  
Damien Coisne ◽  
Mathieu Lugiez ◽  
Marcel Rutten ◽  
...  
Keyword(s):  
In Silico ◽  
Speckle Tracking ◽  
Left Ventricular ◽  
In Vivo Study ◽  
Navier Stokes ◽  
Flow Estimation

scholarly journals Potential anti-diabetic properties of Merlot grape pomace extract: An in vitro, in silico and in vivo study of α-amylase and α-glucosidase inhibition

2020 ◽  
Vol 137 ◽  
pp. 109462 ◽  
Author(s):  
Camila Gabriel Kato-Schwartz ◽  
Rúbia Carvalho Gomes Corrêa ◽  
Diego de Souza Lima ◽  
Anacharis Babeto de Sá-Nakanishi ◽  
Geferson de Almeida Gonçalves ◽  
...  
Keyword(s):  
In Silico ◽  
Grape Pomace ◽  
In Vivo Study

Abstract 100: A MicroRNA Signature for Left Ventricular Reverse Remodeling in Chronic Systolic Heart Failure

2017 ◽  
Vol 121 (suppl_1) ◽  
Author(s):  
Olivia Ziegler ◽  
Ravi Shah ◽  
Kirsty Danielson ◽  
Chun Yang Xiao ◽  
Dustin Rabideau ◽  
...  
Keyword(s):  
Heart Failure ◽  
In Silico ◽  
Systolic Heart Failure ◽  
Left Ventricular ◽  
Reverse Remodeling ◽  
Murine Models ◽  
Clinical Model ◽  
Left Ventricular Reverse Remodeling

Introduction: Left ventricular reverse remodeling (LVRR) in heart failure (HF) is linked to improved patient outcomes. Current strategies to identify individuals who respond favorably to therapy in HF are limited. Though circulating microRNAs (miRs) show epigenetic regulation of LVRR in vivo , there is little clinical data linking plasma-circulating miRs to LVRR. Here we employ a point-of-care microRNA assay, Firefly, in silico analyses, and murine models of HF to characterize profiles of circulating miRs that prognosticate LVRR in patients with HF undergoing guideline directed therapy. Hypothesis: Profiles of miRs in circulating plasma will prognosticate LVRR in patients with HF better than the current clinical model alone and may play a functional role in LVRR. Methods: Plasma from 64 patients from the PROTECT study who had serial echocardiography and available plasma at pre-randomization study visit were run on Abcam’s Firefly platform to assay levels of 51 miRs, selected on prior sequencing efforts (for discovery) and published roles in CVD. miR levels were subject to PC analysis to predict LVRR. Candidate miRs were then validated in a murine model of transverse aortic constriction-induced heart failure (TAC-HF) and their function assessed in cardiomyocyte culture systems. Results: Principle component analysis revealed 4 PCs accounting for 62.4% of the observed variation without significant association with extant markers of HF. When PC2 miR levels were added to the clinical model prognostic ability for LVRR improved substantially (AIC 79.5, (OR=6.84, 95% CI 1.81-25.80, P= 0.005). In silico analysis was then applied to generate networks of mRNAs regulated by PC2 miRs. In the murine TAC-HF model, miRs 423, 212, 221, 193b were differentially regulated, as were the predicted targets of these miRs. These miRs, particularly in combination, appeared to be regulators of cardiac hypertrophy in vitro . Conclusions: Circulating miR profiles in HF improve prognosticative ability for patients who will undergo LVRR over the clinical model alone. Additionally these miRs and their targets are dynamically regulated in murine models of HF, suggesting they may have functional and potential therapeutic utility in addition to their prognostic power.

scholarly journals RANOLAZINE AT THE END OF TRASTUZUMAB THERAPY PREVENTS LEFT VENTRICULAR DYSFUNCTION: IN VITRO AND IN VIVO STUDY

2016 ◽  
Vol 67 (13) ◽  
pp. 1354
Author(s):  
Nicola Maurea ◽  
Carmela Coppola ◽  
Giovanna Piscopo ◽  
Domenica Rea ◽  
Gennaro Riccio ◽  
...  
Keyword(s):  
Left Ventricular Dysfunction ◽  
Ventricular Dysfunction ◽  
Left Ventricular ◽  
In Vivo Study ◽  
Trastuzumab Therapy

Tagitinin F has anti-inflammatory, anti-nociceptive and anti-matrix metalloproteinase properties: An in silico, in vitro and in vivo study

2020 ◽  
pp. 105303
Author(s):  
Laíla Pereira Silva ◽  
Eliziária Cardoso Santos ◽  
Bruno Arantes Borges ◽  
Marcia Paranho Veloso ◽  
Daniela Aparecida Chagas-Paula ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
In Silico ◽  
In Vivo Study ◽  
Anti Inflammatory

DPP-IV inhibitory potential of naringin: An in silico, in vitro and in vivo study

2012 ◽  
Vol 97 (1) ◽  
pp. 105-111 ◽  
Author(s):  
Hamendra Singh Parmar ◽  
Palak Jain ◽  
Digvijay Singh Chauhan ◽  
Mahesh Kumar Bhinchar ◽  
Vibhuti Munjal ◽  
...  
Keyword(s):  
In Silico ◽  
In Vivo Study ◽  
Dpp Iv ◽  
Inhibitory Potential

A synthesis, in silico, in vitro and in vivo study of thieno[2,3-b]pyridine anticancer analogues

MedChemComm ◽  
2015 ◽  
Vol 6 (11) ◽  
pp. 1987-1997 ◽  
Author(s):  
Homayon J. Arabshahi ◽  
Michelle van Rensburg ◽  
Lisa I. Pilkington ◽  
Chae Yeon Jeon ◽  
Mirae Song ◽  
...  
Keyword(s):  
In Silico ◽  
In Vivo Study

The thieno[2,3-b]pyridines bind to TDP1 with the best analogue 9d with IC50 at 0.5 μM.

Does pentobarbital anesthesia depress left ventricular contractility in dogs?

1991 ◽  
Vol 261 (3) ◽  
pp. H700-H706 ◽  
Author(s):  
H. W. Unruh ◽  
R. Wang ◽  
D. Bose ◽  
S. N. Mink
Keyword(s):  
Systolic Pressure ◽  
Ventricular Myocardium ◽  
Left Ventricular ◽  
Isometric Tension ◽  
In Vivo Study ◽  
Adrenergic Blockade ◽  
Serum Concentrations ◽  
Ventricular Contractility

Although pentobarbital sodium (NP) anesthesia has been shown to depress left ventricular (LV) contractility in dogs, measurements of LV contractility in previous studies have been made soon after a bolus of NP was given when serum concentrations would be extremely high. In this study, we compared indexes of LV contractility during awake and anesthetized conditions. During anesthesia, measurements were obtained 1 h after an intravenous bolus of NP was given when serum concentrations were approximately 25 mg/l and above that reported to abolish pain. In 13 dogs, subendocardial ultrasonic crystal transducers and a high-fidelity pressure transducer were implanted into the LV. Measurements were obtained with and without prior treatment with propranolol to produce beta-adrenergic blockade. LV contractility was assessed by ejection fraction and the end-systolic pressure-volume relationship. The effect of NP on ventricular myocardium was also examined in an in vitro canine right trabecular preparation to compare in vivo and in vitro effects. In the in vivo study, the results showed no decrease in LV contractility during anesthesia regardless of whether propranolol was administered. The in vitro preparation showed only a minimal decrease in isometric tension at the concentrations used in the in vivo study. We conclude that NP anesthesia does not depress LV contractility when concentrations are maintained at approximately 25 mg/l.

Hyphaene thebaica (Doum)-derived extract alleviates hyperglycemia in diabetic rats: A comprehensive in silico, in vitro and in vivo study

2021 ◽  
Author(s):  
nourhan hisham shady ◽  
Heba Ali Hassan ◽  
mahmoud elrehany ◽  
Mohamed Salah Kamel ◽  
Entesar Ali Saber ◽  
...  
Keyword(s):  
In Silico ◽  
Diabetic Rats ◽  
Hypoglycemic Effect ◽  
In Vivo Study

In the present study, we investigated the hypoglycemic effect of different extracts (i.e. organic and aqueous) derived from the fruits of Hyphaene thebaica (doum) on male streptozotocin-induced diabetic rats. Blood...

scholarly journals Targeting DNA Repair through Podophyllotoxin and Rutin Formulation in Hematopoietic Radioprotection: An in Silico, in Vitro, and in Vivo Study

2017 ◽  
Vol 8 ◽  
Author(s):  
M. H. Yashavarddhan ◽  
Sandeep K. Shukla ◽  
Pankaj Chaudhary ◽  
Nitya N. Srivastava ◽  
Jayadev Joshi ◽  
...  
Keyword(s):  
Dna Repair ◽  
In Silico ◽  
In Vivo Study
Sign in / Sign up

Export Citation Format

Share Document