scholarly journals 2090431 Edge-Detected Common Carotid Artery Intima-Media Thickness And Incident Coronary Heart Disease in The Multi-Ethnic Study of Atherosclerosis

2015 ◽  
Vol 41 (4) ◽  
pp. S71-S72
Author(s):  
Joseph Polak ◽  
Daniel O'leary
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Carotid Artery ◽  
Common Carotid Artery ◽  
Intima Media Thickness ◽  
Incident Coronary Heart Disease ◽  
Ethnic Study ◽  
Media Thickness

Abstract P331: Associations Of Coronary Heart Disease With Common Carotid Artery Near And Far-wall Intima-Media Thickness (IMT): The Multi-Ethnic Study Of Atherosclerosis.

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Joseph F Polak ◽  
Moyses Szklo ◽  
Daniel H O'Leary
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Carotid Artery ◽  
Common Carotid Artery ◽  
Intima Media Thickness ◽  
Ethnic Study ◽  
Media Thickness ◽  
C Statistic ◽  
Near Wall

Background: Intima-media thickness (IMT) as measured on ultrasound images of the common carotid artery (CCA) is associated with cardiovascular events and used to measure the effects of lipid lowering interventions. Far wall CCA IMT is favored over near wall IMT based on the physics of ultrasound. Materials and Methods: We studied 6606 members of the Multi-Ethnic Study of Atherosclerosis (MESA), a longitudinal cohort study (mean age 62.1 years; 52.7% female) who had near wall and far wall CCA IMT measurements. Multivariable linear regression models were used to estimate model goodness-of-fit of near wall IMT, far wall IMT, and mean IMT with Framingham risk factors (FRF). Multivariable Cox proportional hazards models were used to estimate hazard ratios for incident coronary heart disease (CHD) events for each IMT variable. Change in Harrell’s C-statistic was used to compare the incremental value of each IMT variable when added to FRF. Results: Mean IMT had the strongest association with risk factors (R2 = 0.31), followed by the near wall (R2 = 0.26) and far wall IMT (R2 = 0.22). Far wall IMT improved the prediction of coronary artery disease events (change in C statistic: 0.009; 95% Confidence Intervals: 0.004, 0.015; p= 0.001) as did mean IMT (p=0.033) but near wall IMT did not. Conclusion: Far wall CCA IMT had the strongest association with incident CHD whereas combined near wall and far wall IMT had the strongest association with risk factors. Selected IMT variables may give different results in intervention trials than in outcome studies.

scholarly journals Carotid Artery Intima-Media Thickness, Carotid Plaque and Coronary Heart Disease and Stroke in Chinese

PLoS ONE ◽  
2008 ◽  
Vol 3 (10) ◽  
pp. e3435 ◽  
Author(s):  
Kuo-Liong Chien ◽  
Ta-Chen Su ◽  
Jiann-Shing Jeng ◽  
Hsiu-Ching Hsu ◽  
Wei-Tien Chang ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Carotid Artery ◽  
Carotid Plaque ◽  
Intima Media Thickness ◽  
Media Thickness

scholarly journals e0491 Association of coronary heart disease with carotid artery intima-media thickness and baPWV

Heart ◽  
2010 ◽  
Vol 96 (Suppl 3) ◽  
pp. A153-A153
Author(s):  
L. Junming ◽  
H. Menjun ◽  
W. Mingjian ◽  
X. Wei ◽  
D. Qinghui ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Carotid Artery ◽  
Intima Media Thickness ◽  
Media Thickness

Associations of edge-detected and manual-traced common carotid artery intima-media thickness with incident peripheral artery disease: The Multi-Ethnic Study of Atherosclerosis

2019 ◽  
Vol 24 (4) ◽  
pp. 306-312
Author(s):  
Joseph F Polak ◽  
David Herrington ◽  
Daniel H O’Leary
Keyword(s):  
Carotid Artery ◽  
Peripheral Artery Disease ◽  
Common Carotid Artery ◽  
Intima Media Thickness ◽  
Cox Proportional Hazards ◽  
Ultrasound Images ◽  
Peripheral Artery ◽  
Ethnic Study ◽  
Media Thickness ◽  
Artery Disease

Common carotid artery (CCA) intima-media thickness (IMT) is associated with coronary heart disease and can be measured on ultrasound images either by hand or with an automated edge detector. The association of CCA IMT with incident peripheral artery disease (PAD) is poorly studied. We studied 5467 participants of the Multi-Ethnic Study of Atherosclerosis composed of non-Hispanic white, Chinese, Hispanic, and African American participants with a mean age of 61.9 years (47.8% men). Framingham Risk Factors, manual-traced IMT (mt-IMT), and edge-detected IMT (ed-IMT) were entered into multivariable Cox proportional hazards models with incident PAD as the outcome. There were 87 events during a median follow-up of 12.2 years. In fully adjusted models and expressing the hazard ratios (HR) as an increment in SD values, both mt-IMT and ed-IMT were significantly associated with incident PAD: HR 1.36 (95% CI: 1.15, 1.61) and 1.29 (95% CI: 1.04, 1.60), respectively. We conclude that ed- and mt-CCA IMT measurements are associated with incident PAD. ClinicalTrials.gov Identifier: NCT00063440

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