scholarly journals Simultaneous Passive Acoustic Mapping and Magnetic Resonance Thermometry for Monitoring of Cavitation-Enhanced Tumor Ablation in Rabbits Using Focused Ultrasound and Phase-Shift Nanoemulsions

2018 ◽  
Vol 44 (12) ◽  
pp. 2609-2624 ◽  
Author(s):  
Calum Crake ◽  
Iason T. Papademetriou ◽  
Yongzhi Zhang ◽  
Natalia Vykhodtseva ◽  
Nathan J. McDannold ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Phase Shift ◽  
Focused Ultrasound ◽  
Tumor Ablation ◽  
Magnetic Resonance Thermometry ◽  
Passive Acoustic ◽  
Acoustic Mapping

scholarly journals A dual-mode hemispherical sparse array for 3D passive acoustic mapping and skull localization within a clinical MRI guided focused ultrasound device

2018 ◽  
Vol 63 (6) ◽  
pp. 065008 ◽  
Author(s):  
Calum Crake ◽  
Spencer T Brinker ◽  
Christian M Coviello ◽  
Margaret S Livingstone ◽  
Nathan J McDannold
Keyword(s):  
Focused Ultrasound ◽  
Dual Mode ◽  
Sparse Array ◽  
Ultrasound Device ◽  
Mri Guided ◽  
Passive Acoustic ◽  
Acoustic Mapping ◽  
Clinical Mri

scholarly journals Enhancement and Passive Acoustic Mapping of Cavitation from Fluorescently Tagged Magnetic Resonance-Visible Magnetic Microbubbles In Vivo

2016 ◽  
Vol 42 (12) ◽  
pp. 3022-3036 ◽  
Author(s):  
Calum Crake ◽  
Joshua Owen ◽  
Sean Smart ◽  
Christian Coviello ◽  
Constantin-C. Coussios ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Passive Acoustic ◽  
Acoustic Mapping

scholarly journals Use of fast spin echo for phase shift magnetic resonance thermometry

2003 ◽  
Vol 18 (4) ◽  
pp. 507-512 ◽  
Author(s):  
Mika W. Vogel ◽  
Peter M.T. Pattynama ◽  
Franck L. Lethimonnier ◽  
Patrick Le Roux
Keyword(s):  
Magnetic Resonance ◽  
Phase Shift ◽  
Spin Echo ◽  
Fast Spin Echo ◽  
Magnetic Resonance Thermometry ◽  
Fast Spin

Spatiotemporal Monitoring of High-Intensity Focused Ultrasound Therapy with Passive Acoustic Mapping

Radiology ◽  
2012 ◽  
Vol 262 (1) ◽  
pp. 252-261 ◽  
Author(s):  
Carl R. Jensen ◽  
Robert W. Ritchie ◽  
Miklós Gyöngy ◽  
James R. T. Collin ◽  
Tom Leslie ◽  
...  
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Ultrasound Therapy ◽  
Passive Acoustic ◽  
Acoustic Mapping

Predicting high‐intensity focused ultrasound thalamotomy lesions using 2D magnetic resonance thermometry and 3D Gaussian modeling

2019 ◽  
Vol 46 (12) ◽  
pp. 5722-5732 ◽  
Author(s):  
Graham M. Seasons ◽  
Erin L. Mazerolle ◽  
Tejas Sankar ◽  
Davide Martino ◽  
Zelma H. T. Kiss ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Magnetic Resonance Thermometry ◽  
Gaussian Modeling

scholarly journals Improved therapeutic antibody delivery to xenograft tumors using cavitation nucleated by gas-entrapping nanoparticles

Nanomedicine ◽  
2021 ◽  
Author(s):  
Megan Grundy ◽  
Luca Bau ◽  
Claudia Hill ◽  
Catherine Paverd ◽  
Christophoros Mannaris ◽  
...  
Keyword(s):  
Focused Ultrasound ◽  
Egf Receptor ◽  
Ultrasound Contrast Agent ◽  
Fold Increase ◽  
Receptor Expression ◽  
Therapeutic Antibody ◽  
Cavitation Nuclei ◽  
Passive Acoustic ◽  
Acoustic Mapping ◽  
Cavitation Activity

Aims: Testing ultrasound-mediated cavitation for enhanced delivery of the therapeutic antibody cetuximab to tumors in a mouse model. Methods: Tumors with strong EGF receptor expression were grown bilaterally. Cetuximab was coadministered intravenously with cavitation nuclei, consisting of either the ultrasound contrast agent Sonovue or gas-stabilizing nanoscale SonoTran Particles. One of the two tumors was exposed to focused ultrasound. Passive acoustic mapping localized and monitored cavitation activity. Both tumors were then excised and cetuximab concentration was quantified. Results: Cavitation increased tumoral cetuximab concentration. When nucleated by Sonovue, a 2.1-fold increase (95% CI 1.3- to 3.4-fold) was measured, whereas SonoTran Particles gave a 3.6-fold increase (95% CI 2.3- to 5.8-fold). Conclusions: Ultrasound-mediated cavitation, especially when nucleated by nanoscale gas-entrapping particles, can noninvasively increase site-specific delivery of therapeutic antibodies to solid tumors.

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