Comparison Between Lidocaine and Glyceryl Trinitrate Ointment for Perianal-intrarectal Local Anesthesia Before Transrectal Ultrasonography-guided Prostate Biopsy: A Placebo-controlled Trial

Urology ◽  
2011 ◽  
Vol 77 (4) ◽  
pp. 905-908 ◽  
Author(s):  
Konstantinos Skriapas ◽  
Charalampos Konstantinidis ◽  
Michael Samarinas ◽  
Stylianos Xanthis ◽  
Aristomenis Gekas
Keyword(s):  
Glyceryl Trinitrate ◽  
Local Anesthesia ◽  
Prostate Biopsy ◽  
Controlled Trial ◽  
Transrectal Ultrasonography ◽  
Glyceryl Trinitrate Ointment

scholarly journals Comparison of efficacy of internal sphincterotomy versus topical 0.2 % glyceryl trinitrate ointment after hemorrhoidectomy.

2020 ◽  
Vol 27 (12) ◽  
pp. 2541-2547
Author(s):  
Muhammad Arif ◽  
Sabih Nofal ◽  
Ahsan Khan ◽  
Mariam Tariq Awana ◽  
Anum Arif
Keyword(s):  
Glyceryl Trinitrate ◽  
Controlled Trial ◽  
P Value ◽  
Chi Square ◽  
Male Predominance ◽  
Internal Sphincterotomy ◽  
Open Hemorrhoidectomy ◽  
Group A ◽  
Group B ◽  
Glyceryl Trinitrate Ointment

Objectives: To compare the efficacy of 0.2% glyceryl trinitrate ointment versus internal sphincterotomy after hemorrhoidectomy. Study Design: Randomized Controlled Trial. Setting: Department of Surgery Unit III, at Lahore General Hospital, Lahore. Period: 6 months (August 2017 to February 2018). Material & Methods: The OPD of the Department of Surgery included 124 patients who satisfied the inclusion criteria. There were two groups of patients, Group A and Group B. Group-A was told to use gloved finger three times daily for 0.2 percent GTN ointment topically. For Group B, lateral internal sphincterotomy was performed as day care procedure. On visit, patients were assessed for pain relief by using VAS. All data was collected using a pre-designed (attached) proforma. In SPSS v23.0 the data were input and analyzed. It was stratified for age, sex, disease duration and hemorrhoid stage. The effectiveness of both groups was compared by using a p-value of 0.05 as significant for a chi-square test. Results: Male predominance; in group-A, 41(66.1%) patients were male and 21(33.9%) were female, while in group-B, 52(83.9%) patients were male and 10(16.1%) were females. Efficacy was found in 11(17.7%) patients in group-A (0.2% GTN) while in 25(40.3%) patients in group-B (Internal sphincterotomy) with p-value of 0.006 which is statistically significant. Conclusion: Open hemorrhoidectomy internal sphincterotomy is an effective method to reduce pain after hemorrhoidectomy in contrast to Glyceryl Trinitrate (GTN) topical cream of 0.2 percent.

S192 Comparison of local anesthesia methods used in transrectal ultrasonography-guided prostate biopsy by visual analog scale

2013 ◽  
Vol 12 (4) ◽  
pp. e1300, S192a-e1300, S192b
Author(s):  
K.B. Cengiz ◽  
E. Korgali ◽  
G. Dundar ◽  
S. Ayan ◽  
G. Gokce ◽  
...  
Keyword(s):  
Local Anesthesia ◽  
Visual Analog Scale ◽  
Prostate Biopsy ◽  
Transrectal Ultrasonography ◽  
Analog Scale

scholarly journals Evaluation of the efficacy of a combination of diltiazem and periprostatic nerve block in pain control during transrectal ultrasonography-guided biopsy of the prostate

2013 ◽  
Vol 95 (5) ◽  
pp. 361-364 ◽  
Author(s):  
T Jindal ◽  
SN Mandal ◽  
G Biswas ◽  
D Karmakar
Keyword(s):  
Nerve Block ◽  
Prostate Biopsy ◽  
Pain Control ◽  
Controlled Trial ◽  
Transrectal Ultrasonography ◽  
Significant Difference ◽  
Randomised Controlled ◽  
Dual Origin ◽  
Probe Insertion ◽  
Periprostatic Nerve Block

Introduction The choice of analgesia during prostate biopsy remains controversial. The pain has dual origin: from the insertion of the probe as well as the biopsy itself. Periprostatic nerve block (PPNB) is currently the gold standard modality for decreasing pain of prostate biopsy but it does not alleviate the pain of probe insertion. A randomised controlled trial was performed to test the efficacy and safety of the combination of topical application of diltiazem gel and PPNB for pain control during transrectal ultrasonography guided prostate biopsy. Methods A total of 73 patients who were to undergo their first prostate biopsy were randomised to receive either 2ml of 2% topical diltiazem gel or a placebo 15 minutes before the biopsy. All the patients then had a PPNB using 1% lignocaine. A ten-point visual analogue scale was used to record the pain immediately after the insertion of the probe and during the biopsy. Any adverse effects were also recorded. Results There was no significant difference in the mean age and prostate volumes between the groups. There was a significantly lower mean pain score due to probe insertion in those patients who received topical diltiazem than in the placebo group (p<0.0001). There was no significant difference between the pain scores during the biopsy itself between the two groups. Conclusions Topical diltiazem significantly reduces the pain of probe insertion during prostate biopsy and can be used effectively as an adjuvant to PPNB.

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