Faculty Opinions recommendation of Topical glyceryl trinitrate ointment for pain related to anal hypertonia after stapled hemorrhoidopexy: a randomized controlled trial.

2013 ◽  
Author(s):  
Kellie Mathis
Keyword(s):  
Randomized Controlled Trial ◽  
Glyceryl Trinitrate ◽  
Controlled Trial ◽  
Stapled Hemorrhoidopexy ◽  
Randomized Controlled ◽  
Topical Glyceryl Trinitrate ◽  
Glyceryl Trinitrate Ointment

scholarly journals Do We Need Fluid Restriction After Stapled Hemorrhoidopexy? A Pilot, Double-Blinded, Randomized Controlled Trial

2021 ◽  
Author(s):  
Nien-Ying Tsai ◽  
Shu-Wen Jao ◽  
Chao-Yang Chen ◽  
Chia-Cheng Wen ◽  
Chien-Chang Kao ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Urinary Retention ◽  
Controlled Trial ◽  
Stapled Hemorrhoidopexy ◽  
Trial Registration ◽  
Fluid Restriction ◽  
Randomized Controlled ◽  
Significant Difference ◽  
Double Blinded ◽  
Restriction Group

Abstract Background: Conventional hemorrhoidectomy leads to a high urinary retention rate and fluid restriction is commonly recommended to minimize complications. However, the need for postoperative fluid restriction among patients who have undergone stapled hemorrhoidopexy is unclear. We aimed to determine whether fluid restriction after stapled hemorrhoidopexy with/without partial external hemorrhoidectomy could reduce urinary retention and postoperative pain.Patients And Methods: In this prospective, double-blinded, randomized controlled trial, we enrolled patients who had grade III or IV hemorrhoids and underwent stapled hemorrhoidopexy with/without partial external hemorrhoidectomy; 250 mL/12 h of sterile 0.9% saline was administered to the fluid restriction group after the operation, and 1000 mL/12 h was given to the non-fluid-restriction group. We focused on the need for fluid restriction after stapled hemorrhoidopexy.Results: Fifty patients were studied in two groups. The surgical outcomes of the two groups were no different. The median subjective pain scores at 0, 8, 16, 24 h after the operation showed no significant difference between the two groups (p = 0.55 at 0 h; p = 0.38 at 8 h; p = 0.98 at 16 h; and p = 0.66 at 24 h). The mean times to first urination after the operation were 700.04 ± 455.03 min in the non-fluid-restriction group and 737.16 ± 426.32 min in the fluid-restriction group (no significant difference; p = 0.67). No postoperative urinary retention was found in either group of patients.Conclusions: Fluid restriction after stapled hemorrhoidopexy is unnecessary.Trial registration: This study was reviewed and approved by the Tri-Service General Hospital Institutional Review Board for human subjects (No. 2-106-05-063). This study also had trial registration with clinicalTrials.gov (Identifier: NCT04459039).

Topical Glyceryl Trinitrate Ointment for Pain Related to Anal Hypertonia After Stapled Hemorrhoidopexy

2013 ◽  
Vol 56 (6) ◽  
pp. 768-773 ◽  
Author(s):  
Francesco Saverio Mari ◽  
Giuseppe Nigri ◽  
Anna Dall’Oglio ◽  
Umile Michele Cosenza ◽  
Andrea Milillo ◽  
...  
Keyword(s):  
Glyceryl Trinitrate ◽  
Stapled Hemorrhoidopexy ◽  
Topical Glyceryl Trinitrate ◽  
Glyceryl Trinitrate Ointment

Sublingual glyceryl trinitrate during colonoscopy and terminal ileal intubation: a randomized controlled trial

2017 ◽  
Vol 62 (1) ◽  
pp. 11-15
Author(s):  
Patsy-Anne Hill ◽  
Sofoklis Panteleimonitis ◽  
Graham McKay ◽  
Carol Watson ◽  
Andre Prach ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Glyceryl Trinitrate ◽  
Controlled Trial ◽  
Sphincter Of Oddi ◽  
Success Rates ◽  
Sublingual Glyceryl Trinitrate ◽  
Randomized Controlled ◽  
Ileal Intubation ◽  
Observation Period

Background and aims Sublingual glyceryl trinitrate has been used as an aid to cannulate the Sphincter of Oddi during endoscopic retrograde cholangiopancreatography. Its role in terminal ileal intubation during colonoscopy is unknown. This study examines the role of sublingual glyceryl trinitrate in terminal ileal intubation during colonoscopy. Methods A triple-blind randomized controlled trial comparing sublingual glyceryl trinitrate (800 µg) vs. placebo (saline) in relation to terminal ileal intubation during colonoscopy was performed. Following caecal intubation, participants received sublingual glyceryl trinitrate/placebo followed by a 2-min observation period before intubation was attempted. Data on time to intubate the terminal ileum and intubation rate were collected. Results A total of 110 patients (age: 58 years (18–75)) were recruited and randomised as per protocol: 54 received sublingual glyceryl trinitrate. Terminal ileal intubation was successful in all patients receiving sublingual glyceryl trinitrate and in 53 (94.6%) of those receiving saline ( p = 0.243: Fischer’s exact). The median time taken for ileal intubation after application of spray was 72.5 (7–900) s in the glyceryl trinitrate group compared with 125 (5–900) s in the placebo group ( p = 0.150: Mann–Whitney). There were no major adverse events reported in either group. Conclusions Terminal ileal intubation rates and timing were very good in both groups. Routine sublingual glyceryl trinitrate was not proven to be beneficial in improving terminal ileal intubation or intubation success rates in the hands of experienced colonoscopists. However, trends in this small study might suggest that glyceryl trinitrate could be useful in the hands of less experienced colonoscopists or in difficult terminal ileal intubation cases.

scholarly journals Rapid Intravenous Glyceryl Trinitrate in Ischemic Damage (RIGID) After Stroke: Rationale, Design and Protocol for a Prospective Randomized Controlled Trial

2021 ◽  
Vol 12 ◽  
Author(s):  
Lipeng Cai ◽  
Gary Rajah ◽  
Honglian Duan ◽  
Jie Gao ◽  
Zhe Cheng ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Glyceryl Trinitrate ◽  
Intravenous Administration ◽  
Controlled Trial ◽  
Intravenous Thrombolysis ◽  
Control Group ◽  
Ischemic Damage ◽  
Randomized Controlled ◽  
Prospective Randomized Controlled Trial ◽  
Intravenous Glyceryl Trinitrate

Background: Despite intravenous thrombolysis and endovascular therapy for acute ischemic stroke (AIS), many survivors still have varying degrees of disability. Glyceryl trinitrate (GTN), a nitric oxide (NO) donor, has been previously reported to induce neuroprotection after AIS. The use of GTN to reduce brain damage after stroke remains yet to be elucidated. This study was designed to explore the safety, feasibility, and preliminary efficacy of intravenous administration of GTN after AIS.Methods: A prospective randomized controlled trial is proposed with AIS patients. Participants will be randomly allocated to GTN group and control group with a 1:1 ratio (n = 40). Both groups will be treated with standard therapies according to the current stroke guidelines. Participants allocated to the GTN group will receive intravenous administration of GTN (5 mg GTN in 50 ml saline at a rate of 0.4 mg/h that is continued for 12.5 h/day for 2 days) within 24 h of symptom onset. Participants allocated to the control group will receive intravenous administration at equal capacity of 0.9% normal saline (NS) (total 50 ml/day at 4 ml/h that is continued for 12.5 h/day for 2 days). The primary outcome is safety [systolic blood pressure (SBP) <110 mmHg, headache], while the secondary outcomes include changes in functional outcome and infarction volume.Discussion: Rapid Intravenous Glyceryl Trinitrate in Ischemic Damage (RIGID) is a prospective randomized controlled trial that aims to ascertain the safety, feasibility, and preliminary efficacy of intravenous GTN as a neuroprotection strategy after AIS. These results will provide parameters for future studies as well as provide insights into treatment effects. Any possible neuroprotective qualities of GTN in AIS will also be elucidated.Trial Registration:www.chictr.org.cn, identifier: ChiCTR2100046271.

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