Long Noncoding RNA IGF2AS is Acting as an Epigenetic Tumor Suppressor in Human Prostate Cancer

Urology ◽  
2019 ◽  
Vol 124 ◽  
pp. 310.e1-310.e8 ◽  
Author(s):  
Qiang Chen ◽  
Ting Sun ◽  
Fang Wang ◽  
Binbin Gong ◽  
Wenjie Xie ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Human Prostate ◽  
Human Prostate Cancer

scholarly journals Going viral? Linking the etiology of human prostate cancer to the PCA 3 long noncoding RNA and oncogenic viruses

2017 ◽  
Vol 9 (10) ◽  
pp. 1327-1330 ◽  
Author(s):  
Andre A Teixeira ◽  
Serena Marchiò ◽  
Emmanuel Dias‐Neto ◽  
Diana N Nunes ◽  
Israel T da Silva ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Human Prostate ◽  
Oncogenic Viruses ◽  
Human Prostate Cancer

Long noncoding RNA BDNF-AS is associated with clinical outcomes and has functional role in human prostate cancer

2018 ◽  
Vol 102 ◽  
pp. 1105-1110 ◽  
Author(s):  
Wensheng Li ◽  
Zhongling Dou ◽  
Shuguang We ◽  
Zhiyi Zhu ◽  
Dong Pan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Clinical Outcomes ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Functional Role ◽  
Human Prostate ◽  
Human Prostate Cancer

MP-03.01 Functional Role of PGP 9.5 as Tumor Suppressor is Inactivated by Promoter CpG Methylation in Human Prostate Cancer

Urology ◽  
2011 ◽  
Vol 78 (3) ◽  
pp. S41
Author(s):  
Y. Mitsui ◽  
M. Hiraki ◽  
N. Arichi ◽  
T. Hiraoka ◽  
M. Sumura ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Functional Role ◽  
Cpg Methylation ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Pgp 9.5

scholarly journals Long Noncoding RNA PVT1 Promotes Prostate Cancer Metastasis by Increasing NOP2 Expression via Targeting Tumor Suppressor MicroRNAs

2020 ◽  
Vol Volume 13 ◽  
pp. 6755-6765 ◽  
Author(s):  
Feng Sun ◽  
Ke Wu ◽  
Zhixian Yao ◽  
Xingyu Mu ◽  
Zhong Zheng ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Cancer Metastasis ◽  
Prostate Cancer Metastasis

scholarly journals 3p21.3 tumor suppressor gene RBM5 inhibits growth of human prostate cancer PC-3 cells through apoptosis

2012 ◽  
Vol 10 (1) ◽  
pp. 247 ◽  
Author(s):  
Lijing Zhao ◽  
Ranwei Li ◽  
Chen Shao ◽  
Ping Li ◽  
Jian Liu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Human Prostate ◽  
Human Prostate Cancer

scholarly journals PRUNE2 is a human prostate cancer suppressor regulated by the intronic long noncoding RNA PCA3

2015 ◽  
Vol 112 (27) ◽  
pp. 8403-8408 ◽  
Author(s):  
Ahmad Salameh ◽  
Alessandro K. Lee ◽  
Marina Cardó-Vila ◽  
Diana N. Nunes ◽  
Eleni Efstathiou ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Rna Editing ◽  
Noncoding Rna ◽  
Regulatory Mechanism ◽  
Suppressor Gene ◽  
Dominant Negative ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Protein Coding ◽  
Double Stranded Rna

Prostate cancer antigen 3 (PCA3) is the most specific prostate cancer biomarker but its function remains unknown. Here we identify PRUNE2, a target protein-coding gene variant, which harbors the PCA3 locus, thereby classifying PCA3 as an antisense intronic long noncoding (lnc)RNA. We show that PCA3 controls PRUNE2 levels via a unique regulatory mechanism involving formation of a PRUNE2/PCA3 double-stranded RNA that undergoes adenosine deaminase acting on RNA (ADAR)-dependent adenosine-to-inosine RNA editing. PRUNE2 expression or silencing in prostate cancer cells decreased and increased cell proliferation, respectively. Moreover, PRUNE2 and PCA3 elicited opposite effects on tumor growth in immunodeficient tumor-bearing mice. Coregulation and RNA editing of PRUNE2 and PCA3 were confirmed in human prostate cancer specimens, supporting the medical relevance of our findings. These results establish PCA3 as a dominant-negative oncogene and PRUNE2 as an unrecognized tumor suppressor gene in human prostate cancer, and their regulatory axis represents a unique molecular target for diagnostic and therapeutic intervention.

Localization of a tumor suppressor gene associated with progression of human prostate cancer within a 1.2 Mb region of 8p22-p21.3

1995 ◽  
Vol 13 (3) ◽  
pp. 168-174 ◽  
Author(s):  
Hiroyoshi Suzuki ◽  
Miburu Emi ◽  
Akira Komiya ◽  
Yoshiyuki Fujiwara ◽  
Ryuichi Yatani ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Human Prostate ◽  
Human Prostate Cancer

Thioredoxin interacting protein (TXNIP) acts as a tumor suppressor in human prostate cancer

2020 ◽  
Vol 44 (10) ◽  
pp. 2094-2106 ◽  
Author(s):  
Ming Xie ◽  
Ruiyan Xie ◽  
Sen Xie ◽  
Yiyi Wu ◽  
Wei Wang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Interacting Protein ◽  
Thioredoxin Interacting Protein
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