Incidence, risk factors and outcomes of urethral recurrence after radical cystectomy for bladder cancer: A systematic review and meta-analysis

IntroductionEmerging evidence has shown that COVID-19 infection may result in right ventricular (RV) disturbance and be associated with adverse clinical outcomes. The aim of this meta-analysis is to summarise the incidence, risk factors and the prognostic effect of imaging RV involvement in adult patients with COVID-19.MethodsA systematical search will be performed in PubMed, EMBase, ISI Knowledge via Web of Science and preprint databases (MedRxiv and BioRxiv) (until October 2021) to identify all cohort studies in adult patients with COVID-19. The primary outcome will be the incidence of RV involvement (dysfunction and/or dilation) assessed by echocardiography, CT or MRI. Secondary outcomes will include the risk factors for RV involvement and their association with all-cause mortality during hospitalisation. Additional outcomes will include the RV global or free wall longitudinal strain (RV-GLS or RV-FWLS), tricuspid annular plane systolic excursion (TAPSE), fractional area change (FAC) and RV diameter. Univariable or multivariable meta-regression and subgroup analyses will be performed for the study design and patient characteristics (especially acute or chronic pulmonary embolism and pulmonary hypertension). Sensitivity analyses will be used to assess the robustness of our results by removing each included study at one time to obtain and evaluate the remaining overall estimates of RV involvement incidence and related risk factors, association with all-cause mortality, and other RV parameters (RV-GLS or RV-FWLS, TAPSE, S’, FAC and RV diameter). Both linear and cubic spline regression models will be used to explore the dose–response relationship between different categories (>2) of RV involvement and the risk of mortality (OR or HR).Ethics and disseminationThere was no need for ethics approval for the systematic review protocol according to the Institutional Review Board/Independent Ethics Committee of Fuwai Hospital. This meta-analysis will be disseminated through a peer-reviewed journal for publication.PROSPERO registration numberCRD42021231689.

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A systematic review and meta-analysis of lymphovascular invasion in patients treated with radical cystectomy for bladder cancer

Urologic Oncology Seminars and Original Investigations ◽

10.1016/j.urolonc.2018.03.018 ◽

2018 ◽

Vol 36 (6) ◽

pp. 293-305 ◽

Cited By ~ 12

Author(s):

Andrea Mari ◽

Shoji Kimura ◽

Beat Foerster ◽

Mohammad Abufaraj ◽

David D'Andrea ◽

...

Keyword(s):

Systematic Review ◽

Bladder Cancer ◽

Radical Cystectomy ◽

Lymphovascular Invasion ◽

Meta Analysis

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Comparison of perioperative and oncologic outcomes between robot-assisted and laparoscopic radical cystectomy for bladder cancer: a systematic review and updated meta-analysis

International Urology and Nephrology ◽

10.1007/s11255-020-02406-0 ◽

2020 ◽

Vol 52 (7) ◽

pp. 1243-1254 ◽

Cited By ~ 2

Author(s):

Dechao Feng ◽

Shengzhuo Liu ◽

Yin Tang ◽

Yubo Yang ◽

Wuran Wei ◽

...

Keyword(s):

Systematic Review ◽

Bladder Cancer ◽

Radical Cystectomy ◽

Meta Analysis ◽

Oncologic Outcomes ◽

Robot Assisted

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Minimally invasive versus open radical cystectomy for bladder cancer: A systematic review and meta-analysis

Journal of International Medical Research ◽

10.1177/0300060519864806 ◽

2019 ◽

Vol 47 (10) ◽

pp. 4604-4618 ◽

Cited By ~ 2

Author(s):

Hongbin Shi ◽

Jiangsong Li ◽

Kui Li ◽

Xiaobo Yang ◽

Zaisheng Zhu ◽

...

Keyword(s):

Systematic Review ◽

Bladder Cancer ◽

Minimally Invasive ◽

Radical Cystectomy ◽

Meta Analysis ◽

Perioperative Outcomes ◽

Transfusion Rate ◽

Lymph Node Yield ◽

Multicenter Rct ◽

Open Radical Cystectomy

Background We performed a systematic review and meta-analysis to evaluate the efficacy and safety of minimally invasive radical cystectomy (MIRC) versus open radical cystectomy (ORC) for bladder cancer. Methods We searched the EMBASE and MEDLINE databases to identify randomized controlled trials (RCTs) of MIRC versus ORC in the treatment of bladder cancer. Results Eight articles describing nine RCTs (803 patients) were analyzed. No significant differences were found between MIRC and ORC in two oncologic outcomes: the recurrence rate and mortality. Additionally, no significant differences were found in three pathologic outcomes: lymph node yield, positive lymph nodes, and positive surgical margins. With respect to perioperative outcomes, however, MIRC showed a significantly longer operating time, less estimated blood loss, lower blood transfusion rate, shorter time to regular diet, and shorter length of hospital stay than ORC. The incidence of complications was similar between the two techniques. We found no statistically significant differences in the above outcomes between robot-assisted radical cystectomy and ORC or between laparoscopic radical cystectomy and ORC with the exception of the complication rate. Conclusions MIRC is an effective and safe surgical approach in the treatment of bladder cancer. However, a large-scale multicenter RCT is needed to confirm these findings.

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