Effect of different inspired fractions of oxygen on F-shunt and arterial partial pressure of oxygen in isoflurane-anaesthetized and mechanically ventilated Shetland ponies

PURPOSE: To investigatge right-to-left shunt determination in dog lungs under inhalantion anesthesia with non-rebreathing and rebreathing systems and fraction of inspired oxygen (F I O2) of 0.9 and 0.4, respectively. METHODS: Two groups of 10 dogs each under inhalation anesthesia with sevoflurane: GI in which it was utilized non-rebreathing semiclosed system and F I O2 = 0.9, and GII in which it was utilized rebreathing semiclosed system and F I O2 = 0.4. The study parameters were: heart rate, medium arterial pressure, right-to-left intrapulmonary shunt, hematocrit, hemoglobin, arterial partial pressure of oxygen, mixed venous partial pressure of oxygen, mixed venous oxygen saturation, arterial partial pressure of carbon dioxide, partial pressure of water in the alveoli. RESULTS: Shunt results were significantly different between the two groups - GI data were higher than GII in all the evaluated moments. Hence, the group with nonrebreathing (GI) developed a superior grade of intrapulmonary shunt when compared with the rebreathing group (GII). The partial pressure of water in the alveoli was significantly higher in GII. CONCLUSION: The inhalation anesthesia with non-rebreathing system and F I O2 = 0.9 developed a higher grade of intrapulmonary right-to-left shunt when compared with the rebreathing system and F I O2 = 0.4. The higher humidity in GII contributed to the result.

Download Full-text

Control of arterial partial pressure of oxygen in patients with respiratory abnormalities using an adaptive observer

Frontiers of Medical & Biological Engineering ◽

10.1163/156855700750265477 ◽

2000 ◽

Vol 10 (4) ◽

pp. 303-318

Author(s):

Katsuki Yoshino ◽

Valeri Kroumov

Keyword(s):

Partial Pressure ◽

Adaptive Observer ◽

Partial Pressure Of Oxygen ◽

Arterial Partial Pressure

Download Full-text

Changes inα-tocopherol and retinol levels during cardiopulmonary bypass correlate with maximal arterial partial pressure of oxygen

Free Radical Research ◽

10.1080/10715760701466389 ◽

2007 ◽

Vol 41 (9) ◽

pp. 1061-1067 ◽

Cited By ~ 2

Author(s):

Irene Valle-Giner ◽

Ezequiel Martí-Bonmatí ◽

Amparo Alegría-Torán ◽

Anastasio Montero ◽

Esteban J. Morcillo

Keyword(s):

Cardiopulmonary Bypass ◽

Partial Pressure ◽

Partial Pressure Of Oxygen ◽

Arterial Partial Pressure

Download Full-text

Prolonged methacholine-induced bronchoconstriction in dogs

Journal of Applied Physiology ◽

10.1152/jappl.1979.47.2.418 ◽

1979 ◽

Vol 47 (2) ◽

pp. 418-424 ◽

Cited By ~ 5

Author(s):

J. W. Ramsdell ◽

P. F. Georghiou

Keyword(s):

Lung Function ◽

Gas Exchange ◽

Lung Compliance ◽

Cholinergic Stimulation ◽

Partial Pressure Of Oxygen ◽

Pulmonary Resistance ◽

Mechanically Ventilated ◽

Arterial Partial Pressure ◽

Dynamic Lung Compliance ◽

And Control

We studied the effect of prolonged airways obstruction induced by extended cholinergic stimulation in five anesthetized, mechanically ventilated dogs. A continuous intravenous metacholine infusion was utilized to maintain pulmonary resistance (RL) at 200--1500% preinfusion levels for 13--23 h. At maximum RL (18.86 +/- 7.74 vs. 2.09 +/- 0.18 (mean +/- SD) cmH2O/ (L/S) PREINfusion; P less than 0.01), dynamic lung compliance (Cdyn) fell from 67.5 +/- 14.6 to 32.7 +/- 11.6 ml/cmH2O (P less than 0.005) and arterial partial pressure of oxygen (PaO2) fell modestly from 95.8 +/- 6.1 Torr preinfusion to 83.2 +/- 12.7 Torr (P less than 0.05). Tachyphylaxis to methacholine developed, requiring increases in infusion rates to maintain elevated RL. Abnormalities in lung function resolved promptly upon termination of the infusion. Two similarly instrumented control animals ventilated for 19 and 25 h without metacholine infusion had no change in RL, Cdyn, or PaO2. Histological examination of the lungs revealed no differences between infused and control animals. In spite of marked increases in RL, prolonged cholinergic stimulation produced only mild changes in gas exchange and no sustained changes in lung function or structure.

Download Full-text

The relationship between mouse arterial partial pressure of oxygen (PaO2) and the effectiveness of localized tumour irradiation

British Journal of Radiology ◽

10.1259/0007-1285-48-572-662 ◽

1975 ◽

Vol 48 (572) ◽

pp. 662-667 ◽

Cited By ~ 26

Author(s):

D. W. Siemann ◽

M. J. Bronskill ◽

R. P. Hill ◽

R. S. Bush

Keyword(s):

Partial Pressure ◽

Partial Pressure Of Oxygen ◽

Arterial Partial Pressure ◽

The Relationship

Download Full-text

Decline in arterial partial pressure of oxygen after exercise: a surrogate marker of pulmonary vascular obstructive disease in patients with atrial septal defect and severe pulmonary hypertension

Cardiology in the Young ◽

10.1017/s1047951110001988 ◽

2011 ◽

Vol 21 (3) ◽

pp. 292-298 ◽

Cited By ~ 3

Author(s):

Srinivas Laksmivenkateshiah ◽

Anil K. Singhi ◽

Balu Vaidyanathan ◽

Edwin Francis ◽

Sundaram R. Karimassery ◽

...

Keyword(s):

Pulmonary Hypertension ◽

Partial Pressure ◽

Atrial Septal Defect ◽

Pulmonary Vascular Resistance ◽

Vascular Resistance ◽

Septal Defect ◽

Resistance Index ◽

Partial Pressure Of Oxygen ◽

Arterial Partial Pressure ◽

Pulmonary Vascular Resistance Index

AbstractObjectivesTo examine the utility of decline in arterial partial pressure of oxygen after exercise as a marker of pulmonary vascular obstructive disease in patients with atrial septal defect and pulmonary hypertension.MethodsTreadmill exercise was performed in 18 patients with atrial septal defect and pulmonary hypertension. Arterial blood gas samples were obtained before and after peak exercise. A decline in the arterial pressure of oxygen of more than 10 millimetres of mercury after exercise was considered significant based on preliminary tests conducted on the controls. Cardiac catheterisation was performed in all patients and haemodynamic data sets were obtained on room air, oxygen, and a mixture of oxygen and nitric oxide (30–40 parts per million).ResultsThere were 10 patients who had more than a 10 millimetres of mercury drop in arterial partial pressure of oxygen after exercise and who had a basal pulmonary vascular resistance index of more than 7 Wood units per square metre. Out of eight patients who had less than a 10 millimetres of mercury drop in arterial partial pressure of oxygen after exercise, seven had a basal pulmonary vascular resistance index of less than 7 Wood units per square metre, p equals 0.0001. A decline in arterial partial pressure of oxygen of more than 10 millimetres of mercury predicted a basal pulmonary vascular resistance index of more than 7 Wood units per square metre with a specificity of 100% and a sensitivity of 90%.ConclusionsA decline in arterial partial pressure of oxygen following exercise appears to predict a high pulmonary vascular resistance index in patients with atrial septal defect and pulmonary hypertension. This test is a useful non-invasive marker of pulmonary vascular obstructive disease in this subset.

Download Full-text