Characterization of neutralizing antibodies to Far Eastern of tick-borne encephalitis virus subtype and the antibody avidity for four tick-borne encephalitis vaccines in human

Vaccine ◽  
2009 ◽  
Vol 27 (21) ◽  
pp. 2899-2904 ◽  
Author(s):  
Galina N. Leonova ◽  
Elena V. Pavlenko
Keyword(s):  
Neutralizing Antibodies ◽  
Encephalitis Virus ◽  
Antibody Avidity ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus ◽  
Far Eastern ◽  
Virus Subtype

Evaluation of vaccine Encepur® Adult for induction of human neutralizing antibodies against recent Far Eastern subtype strains of tick-borne encephalitis virus

Vaccine ◽  
2007 ◽  
Vol 25 (5) ◽  
pp. 895-901 ◽  
Author(s):  
Galina N. Leonova ◽  
Vladimir A. Ternovoi ◽  
Elena V. Pavlenko ◽  
Olga S. Maistrovskaya ◽  
Elena V. Protopopova ◽  
...  
Keyword(s):  
Neutralizing Antibodies ◽  
Encephalitis Virus ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus ◽  
Far Eastern

Isolation and characterization of a Far-Eastern strain of tick-borne encephalitis virus in China

2016 ◽  
Vol 213 ◽  
pp. 6-10 ◽  
Author(s):  
Xiaowei Zhang ◽  
Zhenhua Zheng ◽  
Bo Shu ◽  
Panyong Mao ◽  
Bingke Bai ◽  
...  
Keyword(s):  
Encephalitis Virus ◽  
Isolation And Characterization ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus ◽  
Far Eastern

scholarly journals Computational and Rational Design of Single-Chain Antibody against Tick-Borne Encephalitis Virus for Modifying Its Specificity

Viruses ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1494
Author(s):  
Ivan K. Baykov ◽  
Pavel Y. Desyukevich ◽  
Ekaterina E. Mikhaylova ◽  
Olga M. Kurchenko ◽  
Nina V. Tikunova
Keyword(s):  
Rational Design ◽  
Fold Increase ◽  
Encephalitis Virus ◽  
Chimeric Antibody ◽  
Single Chain ◽  
Single Chain Antibody ◽  
Glycoprotein E ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus ◽  
Far Eastern

Tick-borne encephalitis virus (TBEV) causes 5−7 thousand cases of human meningitis and encephalitis annually. The neutralizing and protective antibody ch14D5 is a potential therapeutic agent. This antibody exhibits a high affinity for binding with the D3 domain of the glycoprotein E of the Far Eastern subtype of the virus, but a lower affinity for the D3 domains of the Siberian and European subtypes. In this study, a 2.2-fold increase in the affinity of single-chain antibody sc14D5 to D3 proteins of the Siberian and European subtypes of the virus was achieved using rational design and computational modeling. This improvement can be further enhanced in the case of the bivalent binding of the full-length chimeric antibody containing the identified mutation.

Prevalence and Molecular Characterization of Tick-Borne Encephalitis Virus inIxodes ricinusTicks Collected in Slovenia

2011 ◽  
Vol 11 (6) ◽  
pp. 659-664 ◽  
Author(s):  
Emina Durmiši ◽  
Nataša Knap ◽  
Ana Saksida ◽  
Tomi Trilar ◽  
Darja Duh ◽  
...  
Keyword(s):  
Molecular Characterization ◽  
Encephalitis Virus ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus

scholarly journals The serological response and long-lasting resistance against infection with louping-ill virus in sheep immunized with a highly attenuated tick-borne encephalitis virus

1969 ◽  
Vol 67 (4) ◽  
pp. 731-738 ◽  
Author(s):  
V. Mayer ◽  
D. Blaškovič ◽  
E. Ernek ◽  
H. Libíková
Keyword(s):  
Neutralizing Antibodies ◽  
Encephalitis Virus ◽  
Serological Response ◽  
Immune Control ◽  
Summer Period ◽  
Tick Borne Encephalitis ◽  
Louping Ill ◽  
Tick Borne Encephalitis Virus

SUMMARYThe vaccination of sheep with one dose of the monkey-and mouse-attenuated tick-borne encephalitis virus (the Hy-HK 28 ‘2’ clone) causes seroconversion from negative into positive in 85% of animals. In sheep with pre-existing virus-neutralizing antibodies and increas of their titres was observed in 81%. The antibodies persisted for at least 12 months after the vaccination and during the summer period of grazing the number of serologically positive animals even increased.The vaccinated animals, in contrast to the non-immune control sheep, developed no viraemia after challenge with the virulent louping-ill virus, performed 11 months after immunization.

Full genome sequences and molecular characterization of tick-borne encephalitis virus strains isolated from human patients

2015 ◽  
Vol 6 (1) ◽  
pp. 38-46 ◽  
Author(s):  
Petra Formanová ◽  
Jiří Černý ◽  
Barbora Černá Bolfíková ◽  
James J. Valdés ◽  
Irina Kozlova ◽  
...  
Keyword(s):  
Molecular Characterization ◽  
Encephalitis Virus ◽  
Full Genome ◽  
Genome Sequences ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus ◽  
Virus Strains

scholarly journals Characterization of Monoclonal Antibodies against Hokkaido Strain Tick-Borne Encephalitis Virus

2000 ◽  
Vol 44 (6) ◽  
pp. 533-536 ◽  
Author(s):  
Kimiyo Komoro ◽  
Daisuke Hayasaka ◽  
Tetsuya Mizutani ◽  
Hiroaki Kariwa ◽  
Ikuo Takashima
Keyword(s):  
Monoclonal Antibodies ◽  
Encephalitis Virus ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus
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