The potential cost-effectiveness of infant pneumococcal vaccines in Australia

Vaccine ◽  
2011 ◽  
Vol 29 (45) ◽  
pp. 8077-8085 ◽  
Author(s):  
Anthony T. Newall ◽  
Prudence Creighton ◽  
David J. Philp ◽  
James G. Wood ◽  
C. Raina MacIntyre
Keyword(s):  
Cost Effectiveness ◽  
Pneumococcal Vaccines ◽  
Potential Cost

Assessing the Potential Cost Effectiveness of Pneumococcal Vaccines in the US

Drugs & Aging ◽  
1999 ◽  
Vol 15 (Supplement 1) ◽  
pp. 31-36 ◽  
Author(s):  
John Hutton ◽  
Cynthia Iglesias ◽  
Tom O. Jefferson
Keyword(s):  
Cost Effectiveness ◽  
Pneumococcal Vaccines ◽  
Potential Cost ◽  
The Us

scholarly journals Acceptability and Feasibility of a Mindfulness Intervention Delivered via Videoconferencing for People With Parkinson’s

2021 ◽  
pp. 089198872098890
Author(s):  
Angeliki Bogosian ◽  
Catherine S. Hurt ◽  
John V. Hindle ◽  
Lance M. McCracken ◽  
Debora A. Vasconcelos e Sa ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cost Effectiveness ◽  
Qualitative Interviews ◽  
Quality Adjusted Life Year ◽  
Secondary Outcome ◽  
Structured Interviews ◽  
Potential Cost ◽  
Mindfulness Intervention ◽  
Related Quality

Mindfulness-based group therapy is a rapidly growing psychological approach that can potentially help people adjust to chronic illness and manage unpleasant symptoms. Emerging evidence suggests that mindfulness-based interventions may benefit people with Parkinson’s. The objective of the paper is to examine the appropriateness, feasibility, and potential cost-effectiveness of an online mindfulness intervention, designed to reduce anxiety and depression for people with Parkinson’s. We conducted a feasibility randomized control trial and qualitative interviews. Anxiety, depression, pain, insomnia, fatigue, impact on daily activities and health-related quality of life were measured at baseline, 4, 8, and 20 weeks. Semi-structured interviews were conducted at the end of the intervention. Participants were randomized to the Skype delivered mindfulness group (n = 30) or wait-list (n = 30). Participants in the mindfulness group were also given a mindfulness manual and a CD with mindfulness meditations. The intervention did not show any significant effects in the primary or secondary outcome measures. However, there was a significant increase in the quality of life measure. The incremental cost-effectiveness ratio was estimated to be £27,107 per Quality-Adjusted Life Year gained. Also, the qualitative study showed that mindfulness is a suitable and acceptable intervention. It appears feasible to run a trial delivering mindfulness through Skype, and people with Parkinson’s found the sessions acceptable and helpful.

Potential cost-effectiveness of therapeutic drug monitoring in patients with resistant hypertension

2014 ◽  
Vol 32 (12) ◽  
pp. 2411-2421 ◽  
Author(s):  
Oliver Chung ◽  
Wanpen Vongpatanasin ◽  
Klaus Bonaventura ◽  
Yair Lotan ◽  
Christian Sohns ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
Therapeutic Drug Monitoring ◽  
Drug Monitoring ◽  
Resistant Hypertension ◽  
Therapeutic Drug ◽  
Potential Cost

scholarly journals PIN63 Cost-Effectiveness Analysis of Anti-Pneumococcal Vaccines in Panama

2011 ◽  
Vol 14 (7) ◽  
pp. A276-A277
Author(s):  
M.A. Lutz ◽  
K. Luciani ◽  
G. Morales ◽  
D.R. Strutton ◽  
C.S. Roberts ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
Cost Effectiveness Analysis ◽  
Pneumococcal Vaccines ◽  
Effectiveness Analysis

scholarly journals Cost Effectiveness of a Home-Based Intervention That Helps Functionally Vulnerable Older Adults Age in Place at Home

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Eric Jutkowitz ◽  
Laura N. Gitlin ◽  
Laura T. Pizzi ◽  
Edward Lee ◽  
Marie P. Dennis
Keyword(s):  
Cost Effectiveness ◽  
Community Dwelling ◽  
Sensitivity Analyses ◽  
Model Parameters ◽  
Potential Cost ◽  
Functional Difficulties ◽  
Age In Place ◽  
Home Based ◽  
Occupational And Physical Therapy ◽  
Home Based Intervention

Evaluating cost effectiveness of interventions for aging in place is essential for adoption in service settings. We present the cost effectiveness of Advancing Better Living for Elders (ABLE), previously shown in a randomized trial to reduce functional difficulties and mortality in 319 community-dwelling elders. ABLE involved occupational and physical therapy sessions and home modifications to address client-identified functional difficulties, performance goals, and home safety. Incremental cost-effectiveness ratio (ICER), expressed as additional cost to bring about one additional year of life, was calculated. Two models were then developed to account for potential cost differences in implementing ABLE. Probabilistic sensitivity analyses were conducted to account for variations in model parameters. By two years, there were 30 deaths (9: ABLE; 21: control). Additional costs for 1 additional year of life was $13,179 for Model 1 and $14,800 for Model 2. Investment in ABLE may be worthwhile depending on society's willingness to pay.

scholarly journals The Potential Cost Effectiveness of Different Dengue Vaccination Programmes in Malaysia: A Value-Based Pricing Assessment Using Dynamic Transmission Mathematical Modelling

2017 ◽  
Vol 35 (5) ◽  
pp. 575-589 ◽  
Author(s):  
Asrul Akmal Shafie ◽  
Hui Yee Yeo ◽  
Laurent Coudeville ◽  
Lucas Steinberg ◽  
Balvinder Singh Gill ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
Mathematical Modelling ◽  
Potential Cost ◽  
A Value

scholarly journals Potential Cost-effectiveness of HIV Viral Load Sample Collection and Testing Methods in Malawi

2019 ◽  
Author(s):  
Joseph B. Babigumira ◽  
Solomon J. Lubinga ◽  
Mindy M. Cheng ◽  
James K. Karichu ◽  
Louis P. Garrison
Keyword(s):  
Viral Load ◽  
Cost Effectiveness ◽  
Treatment Failure ◽  
Test Accuracy ◽  
Sample Collection ◽  
Testing Methods ◽  
Hiv Viral Load ◽  
Potential Cost ◽  
Testing Approach ◽  
The Cost

Abstract Background HIV viral load (VL) monitoring informs antiretroviral therapy failure and helps to guide regimen changes. Typically, VL monitoring is performed using dried blood spot (DBS) samples transported and tested in a centralized laboratory. Novel sample collection technologies based on dried plasma stored on a plasma separation card (PSC) have become available. The cost-effectiveness of these different testing approaches to monitor VL is uncertain, especially in resource-limited settings. The objective of this study is to evaluate the potential cost-effectiveness of HIV VL testing approaches with PSC samples compared to DBS samples in Malawi. Methods We developed a decision-tree model to evaluate the cost-effectiveness of two different sample collection and testing methods—DBS and PSC samples transported and tested at central laboratories. The analysis used data from the published literature and was performed from the Malawi Ministry of Health perspective. We estimated costs of sample collection, transportation, and testing. The primary clinical outcome was test accuracy (proportion of patients correctly classified with or without treatment failure). Sensitivity analysis was performed to assess the robustness of results. Results The estimated test accuracy for a DBS testing approach was 87.5% compared to 97.4% for an approach with PSC. The estimated total cost per patient of a DBS testing approach was $19.39 compared to $17.73 for a PSC approach. Based on this, a PSC-based testing approach “dominates” a DBS-based testing approach (i.e., lower cost and higher accuracy). Conclusion The base-case analysis shows that a testing approach using PSC sample is less costly and more accurate (correctly classifies more patients with or without treatment failure) than with a DBS approach. Our study suggests that a PSC testing approach is likely an optimal strategy for routine HIV VL monitoring in Malawi. However, given the limited data regarding sample viability, additional real-world data are needed to validate the results.

Cost-effectiveness of obeticholic acid for the treatment of non-alcoholic steatohepatitis: an early economic evaluation

2021 ◽  
pp. e20210011
Author(s):  
Chanh-Phong Tran ◽  
John J Kim ◽  
Jordan J Feld ◽  
William WL Wong
Keyword(s):  
Cost Effectiveness ◽  
Drug Cost ◽  
Cost Effective ◽  
Cost Utility ◽  
Sensitivity Analyses ◽  
Decompensated Cirrhosis ◽  
Obeticholic Acid ◽  
Potential Cost ◽  
Alcoholic Steatohepatitis ◽  
Early Results

Background: Currently, there are no pharmacological options available for the treatment of non-alcoholic steatohepatitis (NASH). In the 18-month interim analysis of an ongoing randomized, placebo-controlled phase 3 trial (REGENERATE), early results demonstrated that obeticholic acid (OCA) 25 mg significantly improved fibrosis with no worsening of NASH among patients with NASH and fibrosis compared to placebo (PBO). This study aimed to assess the potential cost-effectiveness of OCA compared to PBO in NASH patients. Methods: A state-transition model was developed to perform a cost-utility analysis comparing two treatment strategies, PBO and OCA 25 mg, from a Canadian public payer perspective. The model time horizon was lifetime with annual cycle lengths. Cost and utility parameters were discounted at 1.5% annually. The efficacy data were obtained from the REGENERATE trial, and costs and utilities were derived from other published literature. Probabilistic and deterministic sensitivity analyses were performed to test the robustness of the model. Results: Treatment with OCA led to reductions of 3.58% in decompensated cirrhosis cases, 3.95% in hepatocellular carcinoma, 7.88% in liver transplant, and 6.01% in liver-related death. However, at an annual price of CDN$36,000, OCA failed to be cost-effective compared to PBO at an incremental cost-effectiveness ratio of $815,514 per quality-adjusted life year (QALY). An 88% reduction in drug price to an annual cost of $4,300 would make OCA cost-effective at a willingness-to-pay threshold of $50,000/QALY. Conclusions: OCA failed to be cost-effective compared to PBO, despite demonstrating clinical benefits due to a high drug cost. A significant price reduction would be needed to make the drug cost-effective.

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