Associating Histopathological Findings with Drug-Induced Kidney Injury Rat Biomarkers in Small Molecule Drug Development—A Case Study

2017 ◽  
Vol 88 ◽  
pp. 213
Author(s):  
Andre Nogueira da Costa ◽  
Marcia Santos ◽  
Pierrette De Ron ◽  
Jean-Pierre Valentin ◽  
Renaud Fleurance ◽  
...  
Keyword(s):  
Drug Development ◽  
Small Molecule ◽  
Kidney Injury ◽  
Drug Induced ◽  
Histopathological Findings ◽  
Small Molecule Drug

scholarly journals Towards Academic Drug Development Guidelines

2019 ◽  
Author(s):  
Christopher Southan
Keyword(s):  
Drug Development ◽  
Success Rate ◽  
Case Studies ◽  
Small Molecule ◽  
Research Productivity ◽  
Medicinal Chemistry ◽  
Academic Development ◽  
Commercial Development ◽  
Small Molecule Drug

This report covers academic small-molecule drug development with a view to distilling guidelines. The first section covers research productivity feeding into commercial development before reviewing the literature on statistics of academic development It then considers differences between probes and drugs before discussing the role of author guidelines in medicinal chemistry and pharmacology journals. Resources for comprehensive compound and target cross-checking are then covered followed by comparisons between public and commercial databases including case studies of selected compounds. It concludes with an outline of new scientific developments that could increase the success rate of academic drug development.

scholarly journals Towards Academic Drug Development Guidelines

2019 ◽  
Author(s):  
Christopher Southan
Keyword(s):  
Drug Development ◽  
Success Rate ◽  
Case Studies ◽  
Small Molecule ◽  
Research Productivity ◽  
Medicinal Chemistry ◽  
Academic Development ◽  
Commercial Development ◽  
Small Molecule Drug

This report covers academic small-molecule drug development with a view to distilling guidelines. The first section covers research productivity feeding into commercial development before reviewing the literature on statistics of academic development It then considers differences between probes and drugs before discussing the role of author guidelines in medicinal chemistry and pharmacology journals. Resources for comprehensive compound and target cross-checking are then covered followed by comparisons between public and commercial databases including case studies of selected compounds. It concludes with an outline of new scientific developments that could increase the success rate of academic drug development.

scholarly journals A homogeneous SIRPα-CD47 cell-based, ligand-binding assay: Utility for small molecule drug development in immuno-oncology

PLoS ONE ◽  
2020 ◽  
Vol 15 (4) ◽  
pp. e0226661 ◽  
Author(s):  
Teresa L. Burgess ◽  
Joshua D. Amason ◽  
Jeffrey S. Rubin ◽  
Damien Y. Duveau ◽  
Laurence Lamy ◽  
...  
Keyword(s):  
Drug Development ◽  
Ligand Binding ◽  
Small Molecule ◽  
Binding Assay ◽  
Ligand Binding Assay ◽  
Small Molecule Drug

scholarly journals Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Progress in Small Molecule Drug Development

2010 ◽  
Vol 3 (5) ◽  
pp. 1530-1549 ◽  
Author(s):  
Praveen P. N. Rao ◽  
Saad N. Kabir ◽  
Tarek Mohamed
Keyword(s):  
Drug Development ◽  
Small Molecule ◽  
Small Molecule Drug ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Towards Academic Drug Development Guidelines

2019 ◽  
Author(s):  
Christopher Southan
Keyword(s):  
Drug Development ◽  
Success Rate ◽  
Case Studies ◽  
Small Molecule ◽  
Research Productivity ◽  
Medicinal Chemistry ◽  
Academic Development ◽  
Commercial Development ◽  
Small Molecule Drug

This report covers academic small-molecule drug development with a view to distilling guidelines. The first section covers research productivity feeding into commercial development before reviewing the literature on statistics of academic development It then considers differences between probes and drugs before discussing the role of author guidelines in medicinal chemistry and pharmacology journals. Resources for comprehensive compound and target cross-checking are then covered followed by comparisons between public and commercial databases including case studies of selected compounds. It concludes with an outline of new scientific developments that could increase the success rate of academic drug development.

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