A new fluorimetric assay to measure cytotoxic T-lymphocyte activity against feline immunodeficiency virus envelope glycoprotein

2008 ◽  
Vol 123 (1-2) ◽  
pp. 150-153 ◽  
Author(s):  
Francesca Bonci ◽  
Elisa Zabogli ◽  
Giulia Freer ◽  
Antonio Merico ◽  
Mauro Bendinelli ◽  
...  
Keyword(s):  
T Lymphocyte ◽  
Feline Immunodeficiency Virus ◽  
Envelope Glycoprotein ◽  
Cytotoxic T Lymphocyte ◽  
Virus Envelope ◽  
Fluorimetric Assay ◽  
Immunodeficiency Virus ◽  
Lymphocyte Activity

scholarly journals Human Immunodeficiency Virus (HIV)–Specific Cytotoxic T Lymphocyte Activity in HIV‐Exposed Seronegative Persons

1999 ◽  
Vol 179 (3) ◽  
pp. 538-547 ◽  
Author(s):  
Nicole F. Bernard ◽  
Christina M. Yannakis ◽  
Jimmy S. Lee ◽  
Christos M. Tsoukas
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Immunodeficiency Virus ◽  
Lymphocyte Activity ◽  
Hiv Exposed

scholarly journals Lentivirus-Specific Cytotoxic T-Lymphocyte Responses Are Rapidly Lost in Thymectomized Cats Infected with Feline Immunodeficiency Virus

2005 ◽  
Vol 79 (13) ◽  
pp. 8237-8242 ◽  
Author(s):  
Kathleen A. Hayes ◽  
Sadi Köksoy ◽  
Andrew J. Phipps ◽  
Wayne R. Buck ◽  
Gary J. Kociba ◽  
...  
Keyword(s):  
T Lymphocyte ◽  
Feline Immunodeficiency Virus ◽  
Cytotoxic T Lymphocyte ◽  
Significant Loss ◽  
Ctl Response ◽  
Virus Load ◽  
Immunodeficiency Virus ◽  
Plasma Virus Load ◽  
Lymphocyte Responses ◽  
Ctl Responses

ABSTRACT To what extent the thymus is needed to preserve the virus-specific cytotoxic T-lymphocyte (CTL) response of lentivirus-infected adults is unclear. Presented here is the first definitive study using thymectomized (ThX) animals to directly evaluate the contribution of thymic function to lentivirus-specific CTL response and the control of lentivirus infections. ThX and mock-ThX cats were inoculated with feline immunodeficiency virus (FIV) and monitored for their FIV-specific CTL responses. Early in infection, both FIV-ThX and FIV-mock-ThX cats produced similar CTL responses, but surprisingly, after 20 weeks, the FIV-ThX cats showed a statistically significant loss of FIV-specific CTL activity, while FIV-infected cats with intact thymuses continued to maintain FIV-specific CTL. The loss of CTL did not affect plasma virus load, which remained elevated for both groups. These results emphasize the importance of thymic integrity in maintaining immunity to lentiviruses, but also bring into question the notion that virus load is regulated predominantly by the virus-specific CTL response.

scholarly journals Mechanism of feline immunodeficiency virus envelope glycoprotein-mediated fusion

Virology ◽  
2004 ◽  
Vol 321 (2) ◽  
pp. 274-286 ◽  
Author(s):  
Himanshu Garg ◽  
Frederick J. Fuller ◽  
Wayne A.F. Tompkins
Keyword(s):  
Feline Immunodeficiency Virus ◽  
Envelope Glycoprotein ◽  
Virus Envelope ◽  
Immunodeficiency Virus
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