Macrocyclic lactone resistance in Dirofilaria immitis: Failure of heartworm preventives and investigation of genetic markers for resistance

2015 ◽  
Vol 210 (3-4) ◽  
pp. 167-178 ◽  
Author(s):  
Catherine Bourguinat ◽  
Alice C.Y. Lee ◽  
Regina Lizundia ◽  
Byron L. Blagburn ◽  
Janice L. Liotta ◽  
...  
Keyword(s):  
Genetic Markers ◽  
Dirofilaria Immitis ◽  
Macrocyclic Lactone ◽  
Macrocyclic Lactone Resistance

scholarly journals Clinical validation of molecular markers of macrocyclic lactone resistance in Dirofilaria immitis

2018 ◽  
Vol 8 (3) ◽  
pp. 596-606 ◽  
Author(s):  
Cristina Ballesteros ◽  
Cassan N. Pulaski ◽  
Catherine Bourguinat ◽  
Kathy Keller ◽  
Roger K. Prichard ◽  
...  
Keyword(s):  
Molecular Markers ◽  
Dirofilaria Immitis ◽  
Macrocyclic Lactone ◽  
Clinical Validation ◽  
Macrocyclic Lactone Resistance

Evaluation of the larval migration inhibition assay for detecting macrocyclic lactone resistance in Dirofilaria immitis

2017 ◽  
Vol 246 ◽  
pp. 76-81 ◽  
Author(s):  
Christopher C. Evans ◽  
Andrew R. Moorhead ◽  
Bobby E. Storey ◽  
Byron L. Blagburn ◽  
Adrian J. Wolstenholme ◽  
...  
Keyword(s):  
Dirofilaria Immitis ◽  
Macrocyclic Lactone ◽  
Inhibition Assay ◽  
Migration Inhibition ◽  
Larval Migration ◽  
Macrocyclic Lactone Resistance

scholarly journals Using population genetics to examine relationships of Dirofilaria immitis based on both macrocyclic lactone-resistance status and geography

2020 ◽  
Vol 283 ◽  
pp. 109125 ◽  
Author(s):  
Julie Sanchez ◽  
Guha Dharmarajan ◽  
Melissa M. George ◽  
Cassan Pulaski ◽  
Adrian J. Wolstenholme ◽  
...  
Keyword(s):  
Population Genetics ◽  
Dirofilaria Immitis ◽  
Macrocyclic Lactone ◽  
Macrocyclic Lactone Resistance

Macrocyclic lactone resistance in Dirofilaria immitis

2011 ◽  
Vol 181 (2-4) ◽  
pp. 388-392 ◽  
Author(s):  
Catherine Bourguinat ◽  
Kathy Keller ◽  
Aron Bhan ◽  
Andrew Peregrine ◽  
Timothy Geary ◽  
...  
Keyword(s):  
Dirofilaria Immitis ◽  
Macrocyclic Lactone ◽  
Macrocyclic Lactone Resistance

Macrocyclic lactone resistance in Dirofilaria immitis by Bourguinat et al.

2011 ◽  
Vol 182 (2-4) ◽  
pp. 380-381
Author(s):  
Catherine Bourguinat ◽  
Aron Bhan ◽  
Andrew Peregrine ◽  
Timothy Geary ◽  
Roger Prichard
Keyword(s):  
Dirofilaria Immitis ◽  
Macrocyclic Lactone ◽  
Macrocyclic Lactone Resistance

Nematode ligand-gated chloride channels: an appraisal of their involvement in macrocyclic lactone resistance and prospects for developing molecular markers

Parasitology ◽  
2007 ◽  
Vol 134 (8) ◽  
pp. 1111-1121 ◽  
Author(s):  
S. McCAVERA ◽  
T. K. WALSH ◽  
A. J. WOLSTENHOLME
Keyword(s):  
Haemonchus Contortus ◽  
Chloride Channels ◽  
Macrocyclic Lactone ◽  
Parasitic Nematodes ◽  
C Elegans ◽  
Molecular Tests ◽  
Cooperia Oncophora ◽  
Macrocyclic Lactone Resistance ◽  
High Level ◽  
Laboratory Models

SUMMARYLigand-gated chloride channels, including the glutamate-(GluCl) and GABA-gated channels, are the targets of the macrocyclic lactone (ML) family of anthelmintics. Changes in the sequence and expression of these channels can cause resistance to the ML in laboratory models, such as Caenorhabditis elegans and Drosophila melanogaster. Mutations in multiple GluCl subunit genes are required for high-level ML resistance in C. elegans, and this can be influenced by additional mutations in gap junction and amphid genes. Parasitic nematodes have a different complement of channel subunit genes from C. elegans, but a few genes, including avr-14, are widely present. A polymorphism in an avr-14 orthologue, which makes the subunit less sensitive to ivermectin and glutamate, has been identified in Cooperia oncophora, and polymorphisms in several subunits have been reported from resistant isolates of Haemonchus contortus. This has led to suggestions that ML resistance may be polygenic. Possible reasons for this, and its consequences for the development of molecular tests for resistance, are explored.

Potential contribution of P-glycoproteins to macrocyclic lactone resistance in the cattle parasitic nematode Cooperia oncophora

2013 ◽  
Vol 188 (1) ◽  
pp. 10-19 ◽  
Author(s):  
Janina Demeler ◽  
Jürgen Krücken ◽  
Salha AlGusbi ◽  
Sabrina Ramünke ◽  
Jessie De Graef ◽  
...  
Keyword(s):  
Macrocyclic Lactone ◽  
Parasitic Nematode ◽  
Potential Contribution ◽  
Cooperia Oncophora ◽  
Macrocyclic Lactone Resistance
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