scholarly journals Raman spectroscopic investigation on the biomedical evolution of spinal cord injury and the therapeutic outcomes of its low-level laser therapy

2022 ◽  
pp. 103337
Author(s):  
Furong Zhang ◽  
Zhuowen Liang ◽  
Dongliang Song ◽  
Zhe Wang ◽  
Kaige Wang ◽  
...  
Author(s):  
Suellen de Oliveira Veronez Silva ◽  
Lívia Assis ◽  
Paula Fernanda Gallani Martin Del Campo ◽  
Katherine Chuere Nunes Duarte ◽  
Flavia de Oliveira ◽  
...  

2013 ◽  
Vol 18 (9) ◽  
pp. 098002 ◽  
Author(s):  
Takahiro Ando ◽  
Shunichi Sato ◽  
Hiroaki Kobayashi ◽  
Hiroshi Nawashiro ◽  
Hiroshi Ashida ◽  
...  

2018 ◽  
Vol 49 (3) ◽  
pp. 1168-1183 ◽  
Author(s):  
Yuze Gong ◽  
Shuang Wang ◽  
Zhuowen Liang ◽  
Zhe Wang ◽  
Xu Zhang ◽  
...  

Background/Aims: Low-level laser therapy (LLLT) leads to complex photochemical responses during the healing process of spinal cord injury (SCI). Confocal Raman Microspectral Imaging (in combination with multivariate analysis) was adopted to illustrate the underlying biochemical mechanisms of LLLT treatment on a SCI rat model. Methods: Using transversal tissue sections, the Raman spectra can identify areas neighboring the injury site, glial scar, cavity, and unharmed white matter, as well as their correlated cellular alterations, such as demyelination and up-regulation of chondroitin sulfate proteoglycans (CSPGs). Multivariate data analysis methods are used to depict the underlying therapeutic effects by highlighting the detailed content and distribution variations of the biochemical constituents. Results: It is confirmed that photon-tissue interactions might lead to a decay of the inhibitory response to remyelination by suppressing CSPG expression, as also morphologically demonstrated by reduced glial scar and cavity areas. An inter-group comparison semi-quantitatively confirms changes in lipids, phosphatidic acid, CSPGs, and cholesterol during SCI and its LLLT treatment, paving the way for in vitro and in vivo understanding of the biochemical changes accompanying pathobiological SCI events. Conclusion: The achieved results in this work not only have once again proved the well-known cellular mechanisms of SCI, but further illustrate the underlying biochemical variability during LLLT treatment, which provide a sound basis for developing real-time Raman methodologies to monitor the efficacy of the SCI LLLT treatment.


2012 ◽  
Author(s):  
Takahiro Ando ◽  
Shunichi Sato ◽  
Hiroaki Kobayashi ◽  
Hiroshi Nawashiro ◽  
Hiroshi Ashida ◽  
...  

2020 ◽  
Vol 11 (4) ◽  
pp. 363-368
Author(s):  
Saeed Vafaei-Nezhad ◽  
Mahnaz Pour Hassan ◽  
Mohsen Noroozian ◽  
Abbas Aliaghaei ◽  
Atefeh Shirazi Tehrani ◽  
...  

2016 ◽  
Vol 32 (2) ◽  
pp. 343-349 ◽  
Author(s):  
Suellen Veronez ◽  
Lívia Assis ◽  
Paula Del Campo ◽  
Flávia de Oliveira ◽  
Gláucia de Castro ◽  
...  

2010 ◽  
Vol 28 (5) ◽  
pp. 669-674 ◽  
Author(s):  
Carla Christina Medalha ◽  
Beatriz Oliveira Amorim ◽  
Jéssica Mayra Ferreira ◽  
Poliane Oliveira ◽  
Rosa Maria Rodrigues Pereira ◽  
...  

Author(s):  
NYu Mal’kova ◽  
MD Petrova

Background: The problem of protecting and maintaining health of workers in the microelectronics industry exposed to adverse occupational factors including tension and overstrain of the muscles of the upper extremities and visual strain, gains special relevance. Objective: Introduction of the developed and patented low-level laser therapy techniques to recover functions of vision and the musculoskeletal system impaired in the course of work. Materials and methods: The study involved 65 chip assemblers aged 26–41 years. Their eyes, the back of the hands, and the collar area were exposed to low-level laser radiation from the red region of the spectrum. All employees were examined by a neurologist and a surgeon and their working conditions were evaluated. The accommodation apparatus was tested using an AKA-01 type accommodation meter. Results: After five 10-minute sessions, we registered an increase in the volume of absolute accommodation during the observation period before and after the work shift by 28 % and 19 %, respectively. On subsequent days of observation, we noted an increase in the accommodation during 10 days, followed by a decrease by the 30th day of observation. Application of preventive techniques helped eliminate spinal cord disorders in all workers. Blood circulation in fingers increased by 66 % compared to the initial condition. Discussion: Low-level laser therapy improves blood supply, intensifies redox processes in the retina of the eye, skin cells, and blood vessels. Conclusions: Low-level laser radiation of the red region of the spectrum relieves the spasm of accommodation and normalizes the efficiency of the accommodation apparatus. Such laser therapy helps eliminate spinal cord disorders and improve blood circulation. Introduction of the developed techniques can prevent occupational diseases and reduce disability in patients.


2011 ◽  
Vol 16 (2) ◽  
pp. 027003 ◽  
Author(s):  
Tarun Saxena ◽  
Bin Deng ◽  
Dennis Stelzner ◽  
Julie Hasenwinkel ◽  
Joseph Chaiken

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