scholarly journals Dengue virus neutralization by human immune sera: Role of envelope protein domain III-reactive antibody

Virology ◽  
2009 ◽  
Vol 392 (1) ◽  
pp. 103-113 ◽  
Author(s):  
W.M.P.B. Wahala ◽  
Annette A. Kraus ◽  
Laura B. Haymore ◽  
Mary Ann Accavitti-Loper ◽  
Aravinda M. de Silva
Keyword(s):  
Dengue Virus ◽  
Envelope Protein ◽  
Protein Domain ◽  
Virus Neutralization ◽  
Human Immune ◽  
Domain Iii ◽  
Reactive Antibody

Paradoxical Role of Dengue Virus Envelope Protein Domain III Antibodies in Dengue Virus Infection

2020 ◽  
Vol 30 (3) ◽  
pp. 199-206
Author(s):  
Sheeza Ali ◽  
Samia Afzal ◽  
Muhammad Zubair Yousaf ◽  
Muhammad Shahid ◽  
Iram Amin ◽  
...  
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Envelope Protein ◽  
Protein Domain ◽  
Virus Envelope ◽  
Dengue Virus Infection ◽  
Virus Envelope Protein ◽  
Domain Iii

Dengue virus envelope protein domain III-elicited antibodies mediate cross-protection against Zika virus in a mouse model

2020 ◽  
Vol 278 ◽  
pp. 197882
Author(s):  
Yongchao Zhou ◽  
Dong Chen ◽  
Lan Yang ◽  
Weiwei Zou ◽  
Zhiliang Duan ◽  
...  
Keyword(s):  
Mouse Model ◽  
Dengue Virus ◽  
Zika Virus ◽  
Envelope Protein ◽  
Cross Protection ◽  
Protein Domain ◽  
Virus Envelope ◽  
Virus Envelope Protein ◽  
Domain Iii

scholarly journals Suppressive effect of dengue virus envelope protein domain III on megakaryopoiesis

Virulence ◽  
2017 ◽  
Vol 8 (8) ◽  
pp. 1719-1731 ◽  
Author(s):  
Guan-Ling Lin ◽  
Hsin-Hou Chang ◽  
Te-Sheng Lien ◽  
Po-Kong Chen ◽  
Hao Chan ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Envelope Protein ◽  
Suppressive Effect ◽  
Protein Domain ◽  
Virus Envelope ◽  
Virus Envelope Protein ◽  
Domain Iii

scholarly journals Characterization of Dengue Virus Complex-Specific Neutralizing Epitopes on Envelope Protein Domain III of Dengue 2 Virus

2008 ◽  
Vol 82 (17) ◽  
pp. 8828-8837 ◽  
Author(s):  
Gregory D. Gromowski ◽  
Nicholas D. Barrett ◽  
Alan D. T. Barrett
Keyword(s):  
Dengue Virus ◽  
Critical Role ◽  
Antigenic Site ◽  
Protein Domain ◽  
Virus Infectivity ◽  
E Proteins ◽  
Mutant Proteins ◽  
Virus Complex ◽  
Domain Iii

ABSTRACT The surface of the mature dengue virus (DENV) particle is covered with 180 envelope (E) proteins arranged as homodimers that lie relatively flat on the virion surface. Each monomer consists of three domains (ED1, ED2, and ED3), of which ED3 contains the critical neutralization determinant(s). In this study, a large panel of DENV-2 recombinant ED3 mutant proteins was used to physically and biologically map the epitopes of five DENV complex-specific monoclonal antibodies (MAbs). All five MAbs recognized a single antigenic site that includes residues K310, I312, P332, L389, and W391. The DENV complex antigenic site was located on an upper lateral surface of ED3 that was distinct but overlapped with a previously described DENV-2 type-specific antigenic site on ED3. The DENV complex-specific MAbs required significantly higher occupancy levels of available ED3 binding sites on the virion, compared to DENV-2 type-specific MAbs, in order to neutralize virus infectivity. Additionally, there was a great deal of variability in the neutralization efficacy of the DENV complex-specific MAbs with representative strains of the four DENVs. Overall, the differences in physical binding and potency of neutralization observed between DENV complex- and type-specific MAbs in this study demonstrate the critical role of the DENV type-specific antibodies in the neutralization of virus infectivity.

scholarly journals Anti-dengue virus envelope protein domain III IgG ELISA among infants with primary dengue virus infections

Acta Tropica ◽  
2015 ◽  
Vol 142 ◽  
pp. 103-107 ◽  
Author(s):  
Daniel H. Libraty ◽  
Lei Zhang ◽  
AnaMae Obcena ◽  
Job D. Brion ◽  
Rosario Z. Capeding
Keyword(s):  
Dengue Virus ◽  
Envelope Protein ◽  
Protein Domain ◽  
Virus Infections ◽  
Virus Envelope ◽  
Virus Envelope Protein ◽  
Domain Iii

Bacterially expressed and refolded envelope protein (domain III) of dengue virus type-4 binds heparan sulfate

2007 ◽  
Vol 846 (1-2) ◽  
pp. 184-194 ◽  
Author(s):  
Priyabrata Pattnaik ◽  
J. Pradeep Babu ◽  
Shailendra Kumar Verma ◽  
Vijay Tak ◽  
P.V. Lakshmana Rao
Keyword(s):  
Dengue Virus ◽  
Heparan Sulfate ◽  
Virus Type ◽  
Envelope Protein ◽  
Protein Domain ◽  
Domain Iii

scholarly journals Production of dengue virus envelope protein domain III-based antigens in tobacco chloroplasts using inducible and constitutive expression systems

2016 ◽  
Vol 91 (4-5) ◽  
pp. 497-512 ◽  
Author(s):  
Johanna Gottschamel ◽  
Andreas Lössl ◽  
Stephanie Ruf ◽  
Yanliang Wang ◽  
Morten Skaugen ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Envelope Protein ◽  
Constitutive Expression ◽  
Protein Domain ◽  
Expression Systems ◽  
Virus Envelope ◽  
Virus Envelope Protein ◽  
Domain Iii
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