Identification of conformational epitopes and antigen-specific residues at the D/A domains and the extramembrane C-terminal region of E2 glycoprotein of classical swine fever virus

2012 ◽  
Vol 168 (1-2) ◽  
pp. 56-63 ◽  
Author(s):  
Chia-Yi Chang ◽  
Chin-Cheng Huang ◽  
Ming-Chung Deng ◽  
Yeou-Liang Huang ◽  
Yu-Ju Lin ◽  
...  
Keyword(s):  
Classical Swine Fever Virus ◽  
Classical Swine Fever ◽  
Terminal Region ◽  
Fever Virus ◽  
E2 Glycoprotein ◽  
Conformational Epitopes ◽  
A Domains

scholarly journals Mutations in the carboxyl terminal region of E2 glycoprotein of classical swine fever virus are responsible for viral attenuation in swine

Virology ◽  
2007 ◽  
Vol 364 (2) ◽  
pp. 371-382 ◽  
Author(s):  
G.R. Risatti ◽  
L.G. Holinka ◽  
I. Fernandez Sainz ◽  
C. Carrillo ◽  
G.F. Kutish ◽  
...  
Keyword(s):  
Classical Swine Fever Virus ◽  
Classical Swine Fever ◽  
Terminal Region ◽  
Fever Virus ◽  
E2 Glycoprotein ◽  
Carboxyl Terminal ◽  
Viral Attenuation

scholarly journals A Novel E2 Glycoprotein Subunit Marker Vaccine Produced in Plant Is Able to Prevent Classical Swine Fever Virus Vertical Transmission after Double Vaccination

Vaccines ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 418
Author(s):  
Youngmin Park ◽  
Yeonsu Oh ◽  
Miaomiao Wang ◽  
Llilianne Ganges ◽  
José Alejandro Bohórquez ◽  
...  
Keyword(s):  
Vertical Transmission ◽  
Classical Swine Fever Virus ◽  
Neutralizing Antibodies ◽  
Subunit Vaccine ◽  
Vaccine Dose ◽  
Classical Swine Fever ◽  
Fever Virus ◽  
Tissue Samples ◽  
Marker Vaccine ◽  
E2 Glycoprotein

The efficacy of a novel subunit vaccine candidate, based in the CSFV E2 glycoprotein produced in plants to prevent classical swine fever virus (CSFV) vertical transmission, was evaluated. A Nicotiana benthamiana tissue culture system was used to obtain a stable production of the E2-glycoprotein fused to the porcine Fc region of IgG. Ten pregnant sows were divided into three groups: Groups 1 and 2 (four sows each) were vaccinated with either 100 μg/dose or 300 μg/dose of the subunit vaccine at 64 days of pregnancy. Group 3 (two sows) was injected with PBS. Groups 1 and 2 were boosted with the same vaccine dose. At 10 days post second vaccination, the sows in Groups 2 and 3 were challenged with a highly virulent CSFV strain. The vaccinated sows remained clinically healthy and seroconverted rapidly, showing efficient neutralizing antibodies. The fetuses from vaccinated sows did not show gross lesions, and all analyzed tissue samples tested negative for CSFV replication. However, fetuses of non-vaccinated sows had high CSFV replication in tested tissue samples. The results suggested that in vaccinated sows, the plant produced E2 marker vaccine induced the protective immunogenicity at challenge, leading to protection from vertical transmission to fetuses.

Sequence Analysis of E2 Glycoprotein from Indian Isolate of Classical Swine Fever Virus (CSFV)

2015 ◽  
Vol 43 (1) ◽  
pp. 22-30
Author(s):  
Mehak Bajwa ◽  
Ramneek Verma ◽  
Dipak Deka ◽  
Gagandeep Singh Dhol ◽  
Nagendra Nath Barman
Keyword(s):  
Sequence Analysis ◽  
Classical Swine Fever Virus ◽  
Classical Swine Fever ◽  
Fever Virus ◽  
Indian Isolate ◽  
E2 Glycoprotein

scholarly journals The E2 glycoprotein is necessary but not sufficient for the adaptation of classical swine fever virus lapinized vaccine C-strain to the rabbit

Virology ◽  
2018 ◽  
Vol 519 ◽  
pp. 197-206 ◽  
Author(s):  
Yongfeng Li ◽  
Libao Xie ◽  
Lingkai Zhang ◽  
Xiao Wang ◽  
Chao Li ◽  
...  
Keyword(s):  
Classical Swine Fever Virus ◽  
Classical Swine Fever ◽  
Fever Virus ◽  
E2 Glycoprotein

N-Glycosylation Pattern of E2 Glycoprotein from Classical Swine Fever Virus

2009 ◽  
Vol 8 (2) ◽  
pp. 546-555 ◽  
Author(s):  
Raquel Montesino ◽  
Jorge R. Toledo ◽  
Oliberto Sánchez ◽  
Yasser Zamora ◽  
Maritza Barrera ◽  
...  
Keyword(s):  
Classical Swine Fever Virus ◽  
Classical Swine Fever ◽  
Fever Virus ◽  
Glycosylation Pattern ◽  
E2 Glycoprotein

The N-glycosylation of classical swine fever virus E2 glycoprotein extracellular domain expressed in the milk of goat

2010 ◽  
Vol 500 (2) ◽  
pp. 169-180 ◽  
Author(s):  
Raquel Montesino ◽  
Jeovanis Gil ◽  
Luis J. González ◽  
Yasser Zamora ◽  
Louise Royle ◽  
...  
Keyword(s):  
Classical Swine Fever Virus ◽  
Classical Swine Fever ◽  
Extracellular Domain ◽  
Fever Virus ◽  
E2 Glycoprotein
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