High-mobility group box 1 protein promotes dengue virus replication by interacting with untranslated regions of viral genome

2021 ◽  
pp. 198668
Author(s):  
Nidhi Chaudhary ◽  
Shikha Srivastava ◽  
Upma Dave ◽  
Amrita Ojha ◽  
Prasenjit Guchhait ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Virus Replication ◽  
Viral Genome ◽  
High Mobility ◽  
High Mobility Group ◽  
Untranslated Regions

Dengue virus infection induces passive release of high mobility group box 1 protein by epithelial cells

2008 ◽  
Vol 56 (2) ◽  
pp. 143-150 ◽  
Author(s):  
Lien-Cheng Chen ◽  
Trai-Ming Yeh ◽  
Huey-Nan Wu ◽  
Yi-Ying Lin ◽  
Huey-Wen Shyu
Keyword(s):  
Epithelial Cells ◽  
Virus Infection ◽  
Dengue Virus ◽  
High Mobility ◽  
High Mobility Group ◽  
Dengue Virus Infection ◽  
Passive Release

scholarly journals Dengue virus infection promotes translocation of high mobility group box 1 protein from the nucleus to the cytosol in dendritic cells, upregulates cytokine production and modulates virus replication

2009 ◽  
Vol 90 (8) ◽  
pp. 1827-1835 ◽  
Author(s):  
Edwin Kamau ◽  
Ratree Takhampunya ◽  
Tao Li ◽  
Eileen Kelly ◽  
Kristina K. Peachman ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Dengue Virus ◽  
Inflammatory Responses ◽  
High Mobility ◽  
Cell Types ◽  
Denv Infection ◽  
High Mobility Group ◽  
Regulation Of Transcription ◽  
Hmgb1 Protein ◽  
Necrosis Factor Alpha

High mobility group box 1 (HMGB1) protein functions in regulation of transcription, cellular activation and pro-inflammatory responses. However, the potential role of HMGB1 during viral infection has not been investigated. This study attempted to elucidate whether the HMGB1-mediated inflammatory response contributes to the pathogenesis of dengue virus (DENV) infection. Our data showed that HMGB1 was released at low DENV infection levels (m.o.i. of 1) under non-necrotic conditions by human dendritic cells (DCs). When DENV-infected DCs were co-cultured with autologous T cells, there was increased production of HMGB1 by both cell types. HMGB1 regulated tumour necrosis factor alpha, interleukin (IL)-6, IL-8 and alpha interferon secretion in DENV-infected DCs. Additionally, increased HMGB1 production was associated with reduced DENV replication titres in DCs. These results suggest that HMGB1 production influences DENV infection in susceptible hosts.

scholarly journals Structural complexity of Dengue virus untranslated regions: cis -acting RNA motifs and pseudoknot interactions modulating functionality of the viral genome

2013 ◽  
Vol 41 (9) ◽  
pp. 5075-5089 ◽  
Author(s):  
Joanna Sztuba-Solinska ◽  
Tadahisa Teramoto ◽  
Jason W. Rausch ◽  
Bruce A. Shapiro ◽  
Radhakrishnan Padmanabhan ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Viral Genome ◽  
Structural Complexity ◽  
Untranslated Regions ◽  
Rna Motifs ◽  
Cis Acting
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