scholarly journals GLP-1: A novel zinc finger protein required in somatic cells of the gonad for germ cell development

2007 ◽  
Vol 301 (1) ◽  
pp. 106-116 ◽  
Author(s):  
Shanru Li ◽  
Min Min Lu ◽  
Deying Zhou ◽  
Stephen R. Hammes ◽  
Edward E. Morrisey
Keyword(s):  
Germ Cell ◽  
Zinc Finger ◽  
Zinc Finger Protein ◽  
Somatic Cells ◽  
Cell Development ◽  
Germ Cell Development ◽  
Finger Protein

Functions of promyelocytic leukaemia zinc finger (Plzf) in male germline stem cell development and differentiation

2019 ◽  
Vol 31 (8) ◽  
pp. 1315 ◽  
Author(s):  
Daguia Zambe John Clotaire ◽  
Yudong Wei ◽  
Xiuwei Yu ◽  
Tamgue Ousman ◽  
Jinlian Hua
Keyword(s):  
Stem Cells ◽  
Zinc Finger ◽  
Zinc Finger Protein ◽  
Development Stage ◽  
Cell Development ◽  
Promyelocytic Leukaemia ◽  
Germline Stem Cell ◽  
Germline Stem Cells ◽  
Male Germline ◽  
Finger Protein

Promyelocytic leukaemia zinc finger (Plzf), also known as zinc finger and BTB domain containing 16 (ZBTB16) or zinc-finger protein 145 (ZFP145), is a critical zinc finger protein of male germline stem cells (mGSCs). Multiple lines of evidence indicate that Plzf has a central role in the development, differentiation and maintenance of many stem cells, including mGSCs, and Plzf has been validated as an essential transcription factor for mammalian testis development and spermatogenesis. This review summarises current literature focusing on the significance of Plzf in maintaining and regulating self-renewal and differentiation of mGSCs, especially goat mGSCs. The review summarises evidence of the specificity of Plzf expression in germ cell development stage, the known functions of Plzf and the microRNA-mediated mechanisms that control Plzf expression in mGSCs.

scholarly journals Ovol2, a zinc finger transcription factor, is dispensable for spermatogenesis in mice

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Jin Zhang ◽  
Juan Dong ◽  
Weibing Qin ◽  
Congcong Cao ◽  
Yujiao Wen ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Germ Cell ◽  
Zinc Finger ◽  
Germ Cells ◽  
Cell Development ◽  
Knockout Mouse Model ◽  
Zinc Finger Transcription Factor ◽  
Germ Cell Development ◽  
Embryonic Germ Cells ◽  
Protein Levels

AbstractOvol2, a mouse homolog of Drosophila ovo, was identified as a zinc finger transcription factor predominantly expressed in testis. However, the function of Ovol2 in postnatal male germ cell development remains enigmatic. Here, we firstly examined the mRNA and protein levels of Ovol2 in developing mouse testes by RT-qPCR and western blot and found that both mRNA and protein of Ovol2 are continually expressed in postnatal developing testes from postnatal day 0 (P0) testes to adult testes (P56) and exhibits its higher level at adult testis. Further testicular immuno-staining revealed that OVOL2 is highly expressed in the spermatogonia, spermatocytes and round spermatids. Interestingly, our conditional ovol2 knockout mouse model show that loss of ovol2 in embryonic germ cells does not affect fecundity in mice. Our data also show that Ovol1 may have compensated for the loss of Ovol2 functions in germ cells. Overall, our data indicate that ovol2 is dispensable for germ cell development and spermatogenesis.

scholarly journals Identification of Zfp393, a germ cell-specific gene encoding a novel zinc finger protein

2002 ◽  
Vol 118 (1-2) ◽  
pp. 233-239 ◽  
Author(s):  
Wei Yan ◽  
Kathleen H Burns ◽  
Lang Ma ◽  
Martin M Matzuk
Keyword(s):  
Germ Cell ◽  
Zinc Finger ◽  
Zinc Finger Protein ◽  
Specific Gene ◽  
Gene Encoding ◽  
Finger Protein

scholarly journals Translocation of the Zinc Finger Protein Basonuclin from the Mouse Germ Cell Nucleus to the Midpiece of the Spermatozoon during Spermiogenesis1

1998 ◽  
Vol 59 (2) ◽  
pp. 388-394 ◽  
Author(s):  
My G. Mahoney ◽  
Wei Tang ◽  
Ming Ming Xiang ◽  
Stuart B. Moss ◽  
George L. Gerton ◽  
...  
Keyword(s):  
Germ Cell ◽  
Zinc Finger ◽  
Cell Nucleus ◽  
Zinc Finger Protein ◽  
Finger Protein

Analysis of a murine male germ cell-specific transcript that encodes a putative zinc finger protein

1991 ◽  
Vol 30 (3) ◽  
pp. 173-181 ◽  
Author(s):  
Christer Höög ◽  
Martin Schalling ◽  
Eva Grunder-Brundell ◽  
Bertil Daneholt
Keyword(s):  
Germ Cell ◽  
Zinc Finger ◽  
Zinc Finger Protein ◽  
Male Germ Cell ◽  
Specific Transcript ◽  
Finger Protein ◽  
Putative Zinc Finger
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